يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﺮﺛا ﺢﻄﺳ ﺮﺑ ﯽﺘﻣوﺎﻘﻣ –
ﯽﻣﺮﺳ ﻦﯿﺘﻨﻣُا - ﯽﯾاﺮﺤﺻ شﻮﻣ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ و1
هﺪﺷ ﯽﻣﻮﺘﮐراوا
ﯽﭽﻗرﻮﻗ ﻢﯿﺣررﻮﭘ ﻪﻨﻣآ
، 1
ﭼﺮﯿﻣد نﻼﺳرا ﯽ
ﯽﯾﺎﺑﺎﺑ ﻦﯾوﺮﭘ ،2
3
-1 يﺮﺘﮐد يﻮﺠﺸﻧاد ،ﯽﭽﻗرﻮﻗ ﻢﯿﺣررﻮﭘ ﻪﻨﻣآ نﻼﯿﮔ هﺎﮕﺸﻧاد ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ
-2 رﺎﯿﺸﻧاد ،ﯽﭼﺮﯿﻣد نﻼﺳرا نﻼﯿﮔ هﺎﮕﺸﻧاد ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ
-3 دﺎﺘﺳا ﯽﺘﺷاﺪﻬﺑ تﺎﻣﺪﺧ و ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد يژﻮﻟﻮﯾﺰﯿﻓ نﻼﯿﮔ ﯽﻧﺎﻣرد–
هﺪﯿﮑﭼ
يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﺮﺛا ﯽﺳرﺮﺑ ﻖﯿﻘﺤﺗ فﺪﻫ ﺮﺑ ﯽﺘﻣوﺎﻘﻣ –
ﯽﻣﺮﺳ ﺢﻄﺳ ﻦﯿﺘﻨﻣُا
- شﻮﻣ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ و1
.دﻮﺑ هﺪﺷ ﯽﻣﻮﺘﮐراوا ﯽﯾاﺮﺤﺻ 30
ﺮﺳ هدﺎﻣ ﯽﯾاﺮﺤﺻ شﻮﻣ ) ﻢﺷ يﺎﻫ هوﺮﮔ رد
=10 ) ﯽﻣﻮﺘﮐراوا و (n
=20
) ﯽﻣﻮﺘﮐراوا +ﻦﯾﺮﻤﺗ هوﺮﮔﺮﯾز ود ﻞﻣﺎﺷ (n
=10 ؛لﺮﺘﻨﮐ) ﯽﻣﻮﺘﮐراوا هوﺮﮔ و (n
=10 ﻦﯾﺮﻤﺗ .ﺪﻨﺘﻓﺮﮔراﺮﻗ (n
يزاﻮﻫ - ﯽﺘﻣوﺎﻘﻣ ﺖﻋﺮﺳ ﺎﺑ ﻪﺘﻔﻫ8
،ﻪﻘﯿﻗد ﺮﺑ ﺮﺘﻣ20 ﺐﯿﺷ ،زور رد ﻪﻘﯿﻗد60
لدﺎﻌﻣ يا ﻪﻧزو و ﻪﺟرد10 3
،ناﻮﯿﺣ نﺪﺑ نزو ﺪﺻرد ﻞﺼﺘﻣ
ﻦﯿﺘﻨﻣا .ﺪﺷ مﺎﺠﻧا ،ﻞﺼﺘﻣ ناﻮﯿﺣ مد ﻪﺑ -
ﺖﻣوﺎﻘﻣ و اﺰﯾﻻا شور زا هدﺎﻔﺘﺳا ﺎﺑ1
ﺎﺑ ﯽﻨﯿﻟﻮﺴﻧا
HOMA-IR
هزاﺪﻧا ﺸﻧ ﺞﯾﺎﺘﻧ .ﺪﺷ يﺮﯿﮔ داد نﺎ
ﺢﻄﺳ ﻦﯿﺘﻨﻣا - ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﻣﻮﺘﮐراوا+ﻦﯾﺮﻤﺗ هوﺮﮔ1
ﻪﺑ ،ﻢﺷ و ﯽﻣﻮﺘﮐراوا يﺎﻫ هوﺮﮔ يراد ﯽﻨﻌﻣ رﻮﻃ
ﻢﺷ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﻣﻮﺘﮐراوا هوﺮﮔ رد ﻪﮑﯿﻟﺎﺣ رد ؛ﺖﻓﺎﯾ ﺶﯾاﺰﻓا
ﺶﻫﺎﮐ راد ﯽﻨﻌﻣ .ﺖﻓﺎﯾ
ﻣ وا هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﻣﻮﺘﮐراوا+ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘ را
ﯽﻣﻮﺘﮐ ﺶﻫﺎﮐ73
د ﯽﻨﻌﻣ را ﺶﯾاﺰﻓا ﻢﺷ ﻪﺑ ﺖﺒﺴﻧ ﯽﻣﻮﺘﮐراوا هوﺮﮔ رد ﻪﮑﯿﻟﺎﺣ رد ؛ﺖﻓﺎﯾ راد ﯽﻨﻌﻣ
) ﺖﻓﺎﯾ /05
< 0 ؛(P
ﻦﯿﻨﭽﻤﻫ
رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ دﻮﺒﻧ راد ﯽﻨﻌﻣ ﺶﻫﺎﮐ ﻦﯾا ﻪﮐ ﺖﻓﺎﯾ ﺶﻫﺎﮐ ﻢﺷ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﻣﻮﺘﮐراوا+ﻦﯾﺮﻤﺗ هوﺮﮔ
) /05
>0 يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ ﺖﺸﻫ ،ﻦﯾاﺮﺑﺎﻨﺑ .(P
- ﻦﯿﺘﻨﻣا ﺶﯾاﺰﻓا ﺐﺟﻮﻣ ﯽﺘﻣوﺎﻘﻣ -
ﺒﻬﺑ و1 ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ دﻮ
.دﻮﺷ ﯽﻣ ﯽﻣﻮﺘﮐراوا ﯽﯾاﺮﺤﺻ شﻮﻣ رد
يﺪﯿﻠﮐ يﺎﻫ هژاو ﯽﻣﻮﺘﮐراوا شﻮﻣ ،ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ ،ﻦﯿﺘﻨﻣا ،ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ :
Abstract
The aim of this experimental study was to investigate the effect of aerobic -
resistance training on plasma
omentin-1 level and insulin resistance in ovariectomized (OVX) rats. Thirty Female Wistar rats were divided into 2 SHAM (n=10) and OVX (n=20) groups. OVX rats were subdivided into Ovx+sedentary (Sedentary;
n=10) and aerobic -
resistance training (Ovx+Exe; n=10) groups. The exercise consisted of 8 weeks of aerobic-
resistance exercise (20 m/min, 60 min/day, 10% slope, Load; 3% body weight), three days a week, for eight weeks; and Sedetary rats were perched standing treadmill (60 min/day), three days a week, for eight weeks.
Serum omentin concentration was measured by rat omentin ELISA kit. The serum glucose concentration was determined by enzymatic colorimetric method and serum insulin levels were measured by rat insulin ELISA kit.
HOMA-IR was used to estimate the insulin resistance. After eight-week of aerobic-resistance training, Serum omentin-1 level increased in Ovx+Exe group compared to Sedentary and SHAM groups, respectively; whereas it was significantly decreased in Sedentary group compared to SHAM rats. HOMA-IR decreased in Ovx+Exe
compared to Sedentary group; whereas these variables increased in Sedentary group compared to SHAM rats (P
< 0/05). 8-week aerobic-resistance training, without weight loss increased serum omentin level and improved insulin resistance in ovariectomized rats.
ﯽﺷزرو ﻪﯾﺬﻐﺗ و يژﻮﻟﻮﯾﺰﯿﻓ
Key words: Aerobic -
resistance training, Plasma omentin-1 level, Insulin resistance, ovariectomized (OVX)
rats.
ﻪﻣﺪﻘﻣ
مﺎﺠﻧا ﯽﻗوﺮﻋ و ﺐﻠﻗ و ﯽﮑﯿﻟﻮﺑﺎﺘﻣ تﻻﻼﺘﺧا زا يﺮﯿﮔﻮﻠﺟ و ﯽﻗﺎﭼ ﺎﺑ هزرﺎﺒﻣ ﮏﯾژﻮﻟﻮﮐﺎﻣرﺎﻓ ﺮﯿﻏ يﺎﻬﻫار زا ﯽﮑﯾ ﺪﺷﺎﺑ ﯽﻣ ﻢﻈﻨﻣ ﯽﺷزرو تﺎﻨﯾﺮﻤﺗ )
.(50 ﺞﯾﺎﺘﻧ ،ﻦﮑﯿﻟو ﺶﻫﺎﮐ ﺮﺑ ﻢﻈﻨﻣ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﺮﺛا ﻪﺑ طﻮﺑﺮﻣ تﺎﻌﻟﺎﻄﻣ
ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ .ﺖﺳا ﺾﻗﺎﻨﺘﻣ
لﺎﺳ رد نارﺎﮑﻤﻫ و فﺎﮐ نارﺎﮑﻤﻫ و نﻮﺳ ﺪﯾﻮﯾد و2003
) (2007 نﺎﺸﻧ
يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﻪﮐ ﺪﻧداد -
ﺮﺗﺮﺛﺆﻣ ﯽﯾﺎﻬﻨﺗ ﻪﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺑ ﺖﺒﺴﻧ ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ دﻮﺒﻬﺑ رد ﯽﺘﻣوﺎﻘﻣ
ﺖﺳا ) و4 (.6
،ﻞﺑﺎﻘﻣ رد نارﺎﮑﻤﻫ و زﺮﺴﯾو
)1
رد ﯽﺘﻣوﺎﻘﻣ و يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﻪﮐ ﺪﻧداد نﺎﺸﻧ (2013
ﺎﻘﻣ ﺮﺘﺸﯿﺑ ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺎﺑ ﻪﺴﯾ ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ
دﻮﺷ ﯽﻤﻧ )
نارﺎﮑﻤﻫ و ﺰﺘﻨﻠﺳا ﻦﯿﻨﭽﻤﻫ .(6 نﺎﺸﻧ2
) دراﺪﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺑ ﺖﺒﺴﻧ يﺮﺘﺸﯿﺑ ﺮﺛا ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ﻪﮐ ﺪﻧداد .(43
ﻦﯿﺘﻨﻣا - و ﺰﮐﻮﻠﮔ ﺢﻄﺳ ﺶﻫﺎﮐ ﺎﺑ و دﻮﺷ ﯽﻣ ﺢﺷﺮﺗ ﯽﯾﺎﺸﺣا ﯽﺑﺮﭼ ﺖﻓﺎﺑ زا ناواﺮﻓ رﻮﻃ ﻪﺑ ﻪﮐ ﺖﺳا ﯽﻨﯿﮐﻮﭙﯾدآ1
) ﺪﻫد ﯽﻣ دﻮﺒﻬﺑ ار ﯽﻨﯿﻟﻮﺴﻧا ﺖﯿﺳﺎﺴﺣ ،ﻦﯿﻟﻮﺴﻧا ،3
رد .(5 ﯽﮐﺪﻧا تﺎﻌﻟﺎﻄﻣ
ﻦﯿﺘﻨﻣا ﺮﺑ ار ﯽﺷزرو تﺎﻨﯾﺮﻤﺗ ﺮﺛا -
1
.ﺪﻧا هدروآ ﺖﺳد ﻪﺑ ﯽﻀﻗﺎﻨﺘﻣ ﺞﯾﺎﺘﻧ و هدﺮﮐ ﯽﺳرﺮﺑ دﻮﺒﻬﺑ و يزاﻮﻫ ﻦﯾﺮﻤﺗ زا ﺲﭘ ﻦﯿﺘﻨﻣا ﺢﻄﺳ ﺶﯾاﺰﻓا لﺎﺜﻣ رﻮﻄﺑ
) قﺎﭼ نادﺮﻣ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ زا ﻪﺘﻓﺮﮔﺮﺑ
(5 ا هﺪﺷ شراﺰﮔ ﺮﯿﯿﻐﺗ مﺪﻋ ﻪﮑﯿﻟﺎﺣ رد .ﺖﺳ
ﺲﭘ ﻦﯿﺘﻨﻣا راد ﯽﻨﻌﻣ
زا يزاﻮﻫ ﻦﯾﺮﻤﺗ هﺎﻣ3 ﯽﺘﺑﺎﯾدﺮﯿﻏ و قﺎﭼ نﺎﻧز رد
) (ا5 .ﺪﻨﺷﺎﺑ ﯽﻣ ﺾﻗﺎﻨﺘﻣ ﺞﯾﺎﺘﻧ ﻪﻠﻤﺟ ز ،ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ رد ،اﺬﻟ
ﺮﺛا
يزاﻮﻫ ماﻮﺗ تﺎﻨﯾﺮﻤﺗ و ﯽﻧژوﺮﺘﺳاﻮﭙﯿﻫ ﻣ–
ﺎﻘ و ﻦﯿﺘﻨﻣُا ﺢﻄﺳ ﺮﺑ ﯽﺘﻣ -
ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ و مﺮﺳ1 ﺑ
.ﺖﺳا هﺪﺷ ﯽﺳرﺮ
شور و داﻮﻣ
ﺎﻫ
داﺪﻌﺗ ) تراﺮﺣ ﻪﺟرد ﻂﯾاﺮﺷ رد هدﺎﻣ ﯽﯾاﺮﺤﺻ شﻮﻣ ﺮﺳ 30
±2 ﯽﮑﯾرﺎﺗ هرود ،(داﺮﮔ ﯽﺘﻧﺎﺳ ﻪﺟرد 22
ﯽﯾﺎﻨﺷور 12 يﺎﻫ هوﺮﮔ رد ﻪﺘﻋﺎﺳ ﮕﻧ ﯽﯾﺎﺗ5
ﻬ ﻪﺑﻮﺼﻣ ﯽﻫﺎﮕﺸﯾﺎﻣزآ تﺎﻧاﻮﯿﺣ ﺎﺑ رﺎﮐ ﯽﻗﻼﺧا ﻦﯾزاﻮﻣ .ﺪﻧﺪﺷ يراﺪ
ﻦﺳ رد تﺎﻧاﻮﯿﺣ .ﺪﺷ ﺖﯾﺎﻋر نﻼﯿﮔ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻗﻼﺧا ﻪﺘﯿﻤﮐ ﻪﺑ ﯽﮕﺘﻔﻫ13
راﺪﻓﺪﻫ ﯽﻓدﺎﺼﺗ شور
سﺎﺳا ﺮﺑ و يزﺎﺳ ﻦﮕﻤﻫ
) ﻢﺷ يﺎﻫ هوﺮﮔ رد نﺪﺑ نزو = 10
) ﯽﻣﻮﺘﮐراوا و (n
=20 هوﺮﮔﺮﯾز ود ﻞﻣﺎﺷ (n
) ﯽﻣﻮﺘﮐراوا +ﻦﯾﺮﻤﺗ =10
؛لﺮﺘﻨﮐ) ﯽﻣﻮﺘﮐراوا هوﺮﮔ و (n
=10 (n
.ﺪﻨﺘﻓﺮﮔراﺮﻗ زا ﺲﭘ
رد ،ﯽﻣﻮﺘﮐراوا مﺎﺠﻧا
و ﯽﺷﻮﻬﯿﺑ ﻞﺣاﺮﻣ ،ﯽﺣاﺮﺟ سﺮﺘﺳا و ﯽﺷﻮﻬﯿﺑ و وراد ﻖﯾرﺰﺗ ﯽﻟﺎﻤﺘﺣا ﺮﺛا ﻦﯿﺑ زا رﻮﻈﻨﻣ ﻪﺑ ،ﻢﺷ هوﺮﮔ تﺎﻧاﻮﯿﺣ ) ﺪﺷ مﺎﺠﻧا ﺎﻫ ناﺪﻤﺨﺗ فﺬﺣ نوﺪﺑ هﺪﺷ ﯽﻣﻮﺘﮐراوا هوﺮﮔ ﺪﻨﻧﺎﻣ ﯽﺣاﺮﺟ ﺎﻫ شﻮﻣ مﺎﻤﺗ نزو .(1
ياﺬﻏ ﻦﯿﮕﻧﺎﯿﻣ و
ﯽﻓﺮﺼﻣ يﺮﯿﮔ هزاﺪﻧا ﻪﺘﻔﻫ رد رﺎﺑود .ﺪﺷ
ﻫ ﻦﯾﺮﻤﺗ يزاﻮ - ﯽﺘﻣوﺎﻘﻣ ﺖﻋﺮﺳ ﺎﺑ ﻪﺘﻔﻫ8
،ﻪﻘﯿﻗد ﺮﺑ ﺮﺘﻣ20 ﻪﻘﯿﻗد60
ﺐﯿﺷ ،زور رد لدﺎﻌﻣ يا ﻪﻧزو و ﻪﺟرد10
ﺪﺷ مﺎﺠﻧا ،دﻮﺑ ﻞﺼﺘﻣ ناﻮﯿﺣ مد ﻪﺑ ﻪﮐ ،ناﻮﯿﺣ نﺪﺑ نزو ﺪﺻرد3
زا ﻪﺘﻓﺮﮔﺮﺑ) و1
.(2 ﻦﯿﻟﻮﺴﻧا و تر ﻦﯿﺘﻨﻣا ﺖﯿﮐ و اﺰﯾﻻا ﺎﺑ ﻦﯿﺘﻨﻣا ﺰﯿﻧ
.ﺪﺷ يﺮﯿﮔ هزاﺪﻧا تر ﻦﯿﻟﻮﺴﻧا و اﺰﯾﻻا ﺎﺑ
ﺰﮐﻮﻠﮔ ﯽﻣﺮﺳ ﺢﻄﺳ ) ﺪﺷ يﺮﯿﮔ هزاﺪﻧا يﺮﺘﻣﻮﺘﻓ شور ﻪﺑ
.(1
HOMA-IR
ﻖﺒﻃ ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا يﺮﯿﮔ هزاﺪﻧا ﺎﺑ
) ﺪﺷ ﻪﺒﺳﺎﺤﻣ ﺮﯾز لﻮﻣﺮﻓ .(1
1- Visseres et al.
2- Slentz et al.
HOMA-IR=(fasting insulin[μU/mL]×fasting glucose[mmoL/L])/22/5 ﺎﻫﺮﯿﻐﺘﻣ ﻪﺴﯾﺎﻘﻣ ياﺮﺑ ﻮﻣزآ و ﻪﻓﺮﻃ ﮏﯾ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ نﻮﻣزآ زا ﻞﻘﺘﺴﻣ يﺎﻫ هوﺮﮔ رد
ﯽﮐﻮﺗ ﯽﺒﯿﻘﻌﺗ ن رد
ﻧ مﺮ
يرﺎﻣآ راﺰﻓا ي ﻪﺨﺴﻧSPSS
رد22 يراد ﯽﻨﻌﻣ ﺢﻄﺳ /05
<0 هدﺎﻔﺘﺳاP
.ﺪﺷ
ﺎﻫ ﻪﺘﻓﺎﯾ لوﺪﺟ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ ﺖﺸﻫ زا ﺲﭘ ﻒﻠﺘﺨﻣ يﺎﻫ هوﺮﮔ رد ﮏﯿﻟﻮﺑﺎﺘﻣ و ﯽﻧﺪﺑ ﺐﯿﮐﺮﺗ يﺎﻫﺮﯿﻐﺘﻣ رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ .1
ﻪﻠﺣﺮﻣ زا ﺪﻌﺑ
ﻪﺘﻔﻫ8
هوﺮﮔ ﻢﺷ
ﯽﻣﻮﺘﮐراوا
ﯽﻣﻮﺘﮐراوا و ﻦﯾﺮﻤﺗ
داﺪﻌﺗ ﻪﯿﻟوا 10
10 10
)نﺪﺑ ﻪﯿﻟوا نزو (مﺮﮔ
/09
±6 /30 183 /18
6
± /20 186 /94
2
± /00 182
داﺪﻌﺗ 10
9 10
(مﺮﮔ)نﺪﺑ نزو
/41
±5 193 /40
±15 /67
*233 /1
±21 /2
*231
)ﺪﻗ (cm /33
±0 /11 21 /53
±0 /44
*21 /67
±0 /3
*22 †
)BMI gr/cm2 ( /02
±0 /43 0 /02
±0 /51
*0 /03
±0 /46
*0 †
ياﺬﻏ (زور/تر/مﺮﮔ)ﯽﻓﺮﺼﻣ /30
±0 /86 6 /35
±0 /08
*7 /42
±0 /89
*8
†
ﻦﯿﺘﻨﻣا - )1 pg/ml ( /79
±95 1360 /16
±213 /89
*1318 /2
±266
*2062 †
)ﺰﮐﻮﻠﮔ mmol/l ( /44
±33 /69 327 /44
±7 /4
*435 /58
±12 /3
*162 †
ﻦﯿﻟﻮﺴﻧا ) μU/ml ( /28
±0 /14 1 /27
±0 /48
*2 /41
±0 /7
*1 †
)ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ HOMA-IR
( /60
±3 /36 16 /5
±5 /05
*48 /58
±2 /14
†12
) ﻢﺷ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد توﺎﻔﺗ * /05
<0 (P
) ﯽﻣﻮﺘﮐراوا هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد توﺎﻔﺗ† /05
<0 (P
يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
ﻦﯿﺘﻨﻣا ﺢﻄﺳ ﺶﻫﺎﮐ -
ﯽﻣ ﻪﺑﺎﺸﻣ ﺎﺘﺒﺴﻧ ﯽﮑﯿﻟﻮﺑﺎﺘﻣ ﻂﯾاﺮﺷ رد ﻦﯿﺸﯿﭘ يﺎﻫ ﻪﺘﻓﺎﯾ ﺪﯾﻮﻣ ﯽﻋﻮﻧ ﻪﺑ ﯽﻣﻮﺘﮐراوا هوﺮﮔ رد1
نﺎﯿﺑ و ﻦﯿﺘﻨﻣا ﻦﯿﺌﺗوﺮﭘ ﺪﯿﻟﻮﺗ ،ﯽﻣﻮﺘﮐراوا ﻂﯾاﺮﺷ رد ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا ﺶﯾاﺰﻓا تﺎﺷراﺰﮔ سﺎﺳا ﺮﺑ .ﺪﺷﺎﺑ
mRNA
) ﺪﻨﻫد ﯽﻣ ﺶﻫﺎﮐ ار نآ ﻧاﻮﺗ ﯽﻣ ﯽﻣﻮﺘﮐراوا هوﺮﮔ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ دﺎﺠﯾا ﺖﻠﻋ .(3
زﺎﮐﻮﻟ ﺲﻧاﺮﺗ ﺶﻫﺎﮐ ﺪ
GLUT4 ) ﺪﺷﺎﺑ نژوﺮﺘﺳا بﺎﯿﻏ رد ﻪﻠﻀﻋ زﺎﺘﺘﻨﺳ نژﻮﮑﯿﻠﮔ و
زا ﻪﺘﻓﺮﮔﺮﺑ و4
.(6
يزاﻮﻫ ﻦﯾﺮﻤﺗ تﺪﺷ ﺎﺑ ﯽﺘﻣوﺎﻘﻣ –
Vo2max
% -85 ﻦﯿﺘﻨﻣا ﺢﻄﺳ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ70
- و1 ﺖﻣوﺎﻘﻣ ﺶﻫﺎﮐ
ﯽﻨﯿﻟﻮﺴﻧا ﺷ
) نارﺎﮑﻤﻫ و ﯽﻣرﺎﺻ ﻖﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ ﺎﺑ ﻪﺘﻓﺎﯾ ﻦﯾا .ﺪ نارﺎﮑﻤﻫ و ﯽﻣرﺎﺻ .دراد ﯽﻧاﻮﺧ ﻢﻫ (2010
) ﺪﻧداد نﺎﺸﻧ (2010
،يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ 12 تﺪﺷ ﺎﺑ ،ﻪﺘﻔﻫ رد رﺎﺑ 5
- 85 ﺪﺻرد70
Vo2max
ﺢﻄﺳ ،
ﻦﯿﺘﻨﻣا - ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ و ﺶﯾاﺰﻓا نزو ﻪﻓﺎﺿا ياراد و قﺎﭼ نادﺮﻣ رد ار1 ار
ﺸﺨﺑ دﻮﺒﻬﺑ ﺪﯿ
ﺮﮔﺮﺑ) زا ﻪﺘﻓ رد .(5
ﺎﺑ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ يﺎﻫ ﻪﺘﻓﺎﯾ ،ﻞﺑﺎﻘﻣ يﺎﻫ ﻪﺘﻓﺎﯾ
) نارﺎﮑﻤﻫ و اﻮﻧﺎﺑرﻮﯾ (2014
ﻪﮐ ﺪﻧداد نﺎﺸﻧ ،يزاﻮﻫ ﻦﯾﺮﻤﺗ هﺎﻣ3
تﺪﻣ ﻪﺑ ﻪﺘﻔﻫ رد رﺎﺑ3 ﻦﯿﺘﻨﻣا ﺢﻄﺳ رد يراد ﯽﻨﻌﻣ ﺮﯿﯿﻐﺗ ﻪﻘﯿﻗد30
- دﺮﮑﻧ دﺎﺠﯾا ﯽﺘﺑﺎﯾد و قﺎﭼ نﺎﻧز1 ﯽﻧاﻮﺧ ﻢﻫ ،
دراﺪﻧ ) .(5 ﻪﺑ ناﻮﺗ ﯽﻣ ار تﺎﻘﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ رد توﺎﻔﺗ يﺎﻬﻠﮐﻮﺗوﺮﭘ
ﻒﻠﺘﺨﻣ راﺮﮑﺗ و تﺪﻣ ،تﺪﺷ ﺮﻈﻧ زا ﺖﯿﻫﺎﻣ و
.داد ﺖﺒﺴﻧ (ناﻮﯿﺣ ﻞﺑﺎﻘﻣ رد نﺎﺴﻧا) ﺎﻫ ﯽﻧدﻮﻣزآ
يﺎﻫ ﻞﻣﺎﺣ داﺪﻌﺗ ﺶﯾاﺰﻓا ﺎﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ
GLUT4 ،
دﻮﺒﻬﺑ ار ﯽﻨﯿﻟﻮﺴﻧا ﺖﯿﺳﺎﺴﺣ ﺪﻫد ﯽﻣ
) ،4 ﺰﯿﻧ ﻦﯾﺮﻤﺗ .(6
ﯽﺘﻠﮑﺳا ﻪﻠﻀﻋ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﯿﺳﺎﺴﺣ ﮏﯾﺮﺤﺗ ﻖﯾﺮﻃ زا
ﺖﯿﻟﺎﻌﻓ مﺎﮕﻨﻫ ﻪﺑ زﺎﻨﯿﮐ ﻦﯾا .ﺪﻫد ﯽﻣ ﺶﯾاﺰﻓاAMPK
ﯽﯾﺎﺟ ﻪﺑﺎﺟ ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ ﯽﺷزرو
GLUT-4 ) دﻮﺷ ﯽﻣ ﺰﮐﻮﻠﮔ ﺖﺷادﺮﺑ و
،3 ،4 .(6
يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ ،ﻦﯾاﺮﺑﺎﻨﺑ -
لﺮﺘﻨﮐ ﺖﻬﺟ ﯽﺘﺒﺜﻣ دﺮﮑﯾور ﺪﻧاﻮﺗ ﯽﻣ ﯽﺘﻣوﺎﻘﻣ نﺪﺑ نزو
ﺢﻄﺳ ﺶﯾاﺰﻓا ، ﯽﻣﺮﺳ
ﻦﯿﺘﻨﻣا - ﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ ﺶﻫﺎﮐ و1 .ﺪﺷﺎﺑ ﻪﺴﺋﺎﯾ نﺎﻧز رد ﯽﻨ
ﻊﺑﺎﻨﻣ
.1 ،نﻼﺳرا ،ﯽﭼﺮﯿﻣد ،ﻪﻤﯿﺣر ،هداز يﺪﻬﻣ ،ﯽﯾﺎﺸﺣا ﯽﺑﺮﭼ ناﺰﯿﻣ ﺮﺑ ﯽﻨﯾﺰﮕﯾﺎﺟ ﯽﻧﺎﻣرد نژوﺮﺘﺳا و يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺮﺛا ،1388
هﺎﮕﺸﻧاد ،ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هﺪﮑﺸﻧاد ،يﺮﺘﮐد ﻪﻟﺎﺳر ،هﺪﺷ ﯽﻣﻮﺘﮐراوا ﯽﯾاﺮﺤﺻ شﻮﻣ رد ﻦﯿﻟﻮﺴﻧا ﻪﺑ ﺖﯿﺳﺎﺴﺣ و مﺮﺳ ﻦﯿﺘﮑﻧﻮﭙﯾدآ ﺢﻄﺳ نﻼﯿﮔ . 2. Aguiar AF, Agati LB, Muller SS, Pereira OC and Silva MD. (2010). Effects of physical training on the mechanical resistance of rat femur proximal thirds. ActaOrtop Bras, 18(5): 245- 9.
3. Yu D and Gong DW.(2011). Omentin Activates AMP-activated Protein Kinase and Plays a Role in Energy Metabolism and Immune Response. Division of Endocrinology, Diabetes and Nutrition University of Maryland, Baltimore.
4. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, Hawk VH, Muehlbauer MJ, Samsa GP, Nelson RC, Huffman KM, Bales CW, Houmard JA and Kraus WE.(2011). Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab, 301:1033-1039.
5. Urbanova M, Dostalova I, Trachta P, Drapalova J, Kavalkova P, Haluzikova D, Matoulek M, Lacinova Z, Marz M, Kasalicky M and Haluzik, M. (2014).Serum concentrations and subcutaneous adipose tissue mRNA expression of omentin in morbid obesity and type 2 diabetes mellitus: the effect of very-low- calorie diet, physical activity and laparoscopic sleeve gastrectomy. Charles University and General University Hospital, Prague, Czech Republic, 2013, 3-16.
Visseres D, Hens W, Taeymas J, Baeyens JP, Poortmas J and Gaal LV. (2013). The effect of exercise on visceral adipose tissue in overweight adults: A Systematic Review and Meta-Analysis. Diabetes and Metabolism
