• TAP CHi NGHI&N CU'U Y HQC
Summary
THE DIAGNOSTIC VALUE OF SERUM ASCITES ALBUMIN GRADIENT - (SAAG) IN PATIENTS WITH LIVER CIRRHOSIS
The aim of this study was to investigate the significance of SAAG in differentiating aseite and determine the correlation between SAAG and the presence of portal hypertension The result showed that, the mean SAAG value for patients with malignant tuberculosis was 7 11 ± 7 95, while the SAAG value was 23.25 ± 7.69 for patients wilh liver cirrhosis The SAAG cut off value from differentiating ascites from cirrhosis and tuberculosis was 15 2g/L (AUROC 0 812) Using the ROC curve, a SAAG value of greater than 18 6 and 19 7 were a good predictor of the presence of vances and bleeding vances In conclusion, SAAG gradient value was valuable in differentiating ascites caused by portal hypertension or malignancy For cirrhosis patients, SAAG values can be used lo predict the presence of vances, but nol valuable in predicting bleeding from esophageal varices
Keywords: portal h y p e r t e n s i o n , bleeding varices
HIEU QUA CUA VEC-Nl SHELLAC F TRONG NGAN CHAN SAU RANG d TRE 12 TUOI SAU 12 THANG
Nguydn Thj Thiiy Tien, Hoang Trong Hung, T r i n Dii'C T h a n h , Hoang Oao Bao Tram Dai hoc Y Dwoc Thanh phd Ho Chi Mmh Thwnghiem cdng ddng. ngdu nhien, mu don. cd nhdm chimg dwqc thwc hi$n tren 207 tre 12 tudi, sdng d vung khdng bd sung floor trong nwdc smh hoat tai thdnh phd Hd Chi Mmh nham ddnh gid hieu qua cua vec- ni Shellac F trong ngan ch$n sau rdng d tre Hai nhdm thi> nghiem dwqc bdi vec-ni fluor (Shellac F.
Duraphaf) ba thdng mqt ldn, nhdm chimg khdng sir dung vec-ni Khdm ddnh gid sdu rang theo lieu chi ICDAS II bdi 3 ngwdi khdm da dwoc chuan hda. Sau 12 thdng hai nhdm sir dung vec-ni cd ty 1$ gidm sdu rang cao hon nhdm chimg, ty le sdu rang men. sd rang, mat rang sdu mat trdm tmng binh. vd mux: do gia tang sd mat rang sau mdt trdm trung binh thap hon nhdm chimg khi danh gia d mirc SI, khdc biet cd y nghTa thdng ke (p < 0,05). khdng cd khdc biet giu'a hat nhdm sir dqng vec-ni (p > 0.05). ty Id giam sdu rang da thdnh Id d nhdm sir dung Shellac F Id 29% va nhdm su- dung Duraphaf Id 11% so vdi nhdm chimg.
khdng co khac biet cd y nghTa thdng ke (p > 0,05) Vec-ni Shellac F cd hidu qua trong ngan chan sdu rang d tre 12 tudi va hieu qua nay twong dwong vec-ni Duraphat® sau 12 thdng
Tip khoa: vec-ni fluor, Shellac F, ngan chan sau rang, ICDAS II
I
OAT V A N D ^I. U M I VMIN t / c ^, ,^ ^ tre 6 - 8 tudi sdu rdng su'a Id 85%. chi Cdc sd lidu didu tra dich Id hpe eho lhay sd sdu mat trdm rdng sira Id 5,4, va sdu mdt tinh trang sdu rdng a tre em tai Viet Nam edn trdm mdt rdng sira Id 12.98, phdn ldn sdu a mirc cao. Theo didu Ira qudc gia ndm 2000, rdng khdng d u o c didu In Ty Id Ire sdu rang
TAP CHi NGHIEN CO'U Y HQC •
vTnh vidn khd cao vd gia tdng nhanh theo tuoi, a lira tudi 9 - 1 1 Id 54,6% vd d lua tudi 1 5 - 1 7 Id 68,6% Chi sd sdu mdt trdm rdng vTnh vidn vd sdu mdt trdm m^t rdng vTnh vidn d lira tudi 9 - 1 1 tuong irng Id 1,15 vd 1,74, d lira tudi 15 tuong irng Id 2,4 vd 4,16, Ty 1$ khdng duoe didu In eao luong l u d bd rdng sOa [1] Tgi cdc tinh thdnh phia Nam, theo sd lidu didu tra ndm 2000, ty Id sdu rdng vTnh vidn d lira tudi 12 Id 66,37%, lira tudi 15 Id 83,65%, chi sd sdu mdt trdm tuong ung Id 1,88 vd 2,47 [2].
Tai thdnh phd Hd Chi Minh, kdl qud didu tra ndm 1999 cho thdy ehi sd sdu mdt trdm rdng d tre 8 tudi viing nOi thdnh Id 0,68 (±
1,37) vd d viing ngoai thdnh Id 1,19 (+ 1,33), Ndm 2003, kdt qua didu tra ve ty le vd mue dO tram trong cua bdnh sau rang, eua Ddo Thi Hdng Qudn vd edng s u eho thdy (1) O vung fluor hda nudc, ly le sdu rdng Id 36,4%, sdu mdt tram rang id 1,22 va SiC la 2,39, (2) O vung khSng fluor hda nudc, ly Id sdu rdng la 72,9%, sdu mdt trdm rang la 2,7 va SiC Id 4,83 [3j, Vide tim giai phdp hieu qua vd kmh id, phil hop vdl cdc ddi l u o n g cdng ddng vd ca the khac nhau, ddc biet la tre sdng lai viing khdng bd sung fluor trong nudc sinh hogt vd ddi tuong tre ed nguy co sdu rdng eao la mdt edu hdi ddt ra doi vdi cac nhd nghidn ciru Idm sang vd dich Id hoc, Ben canh con dudng toan than, vai trd cua vide s u dung fluor tai chd ngdy cdng d u o c ddnh gid eao, ddc bidt ddi vdi ede ddi tuong ed nguy eo sdu rdng cao hodc khdng cd didu kidn tidp xiic vdi ngudn nude ed bd sung fluor
Vdc-ni fluor la vdt hdu dd d u o c sir dyng d
Dia Chilian he Hoang Dao Bdo Trdm. trudng Dai hqc Y Ouoc Thanh ph6 Ho Chl Mmh. '217 Hdng B^ng. Qudn 5.
thanh pho Ho Chi Mmh Email hoangdaobaotram@gmail com Ngaynhan: 15/01/2013 Ngay aurrc chap thuan 26/4/2013
nhidu n u d e trdn thd gidi Tir ndm 2000, khoa Rdng Hdm Mdt - Dgi hoc Y Dug'C Ihdnh phd Hd Chl Minh, vdi s u hd t r d ciia khoa Nha - Dgi hpe Adelaide {Nam Uc) vd khoa Hda - Ogi hpc Bdch khoa thdnh phd Ho Chi Minh da nghidn ciru chd lao vdc-ni Sheltc F, mdt san phdm phdng ngua sdu rdng cd thdnh phan nhya cdnh kidn do cd bd sung fluor [A]
Nghidn ciru ndy dup'c thuc hidn nhdm ddnh gid hidu qua eiia vdc-ni Shellac F trong ngdn chdn sdu rdng d t r e 12 tudi sau 12 thdng,
II. D 6 | TU'P'NG VA PHU'ONG PHAP
1. Odi tu'O'ng
Thir nghidm edng ddng, phdn nhdm ngau nhidn, mil don, cd nhdm chirng trdn 207 tre 12 tudi dang hoc tai I r u d n g trung hoc co so An Lgc, qudn Binh Tdn. thdnh phd Hd Chl Minh, thda mdn tieu chi chon m i u vd tieu chi loai trir Cdc ddi l u o n g d u o c phdn ngdu nhi^n vdo 3 nhdm nghidn eiru. (1) sir dung Shellac F, (2) sir dung Duraphal®, (3) nhdm chirng.
2. Vat lieu va p h u ' a n g t i e n
Shellac F (Trung lam Khoa hpc Cdng ngh6 Duoc Sdi Gdn): Duraphal® (Colgate Oral Pharmaceuticals), Bp dd khdm vdi guong khdm ed ddn vd thdm trdm ddu trdn; may thdi hoi, Phidu ddnh gid sdu rdng theo tieu chl ICDAS 11
3. Tidn t r i n h
Tdt ca cdc ddi l u o n g nghidn ciru duoc hudng ddn ehai rdng, eung cap kem ddnh rdng vd bdn chai 6 Ihdng/ldn, vd duoc mdi didu tri cae van dd rdng midng c a ban bao gdm lay vdl rdng, tram rdng, chu'a luy vd nhd rdng
Khdm ddnh gid linh trang sdu rdng duoc thuc hidn vdo thdi didm bdt dau nghien ci>u vd thdi diem 6 Ihdng vd 12 thdng Hoc sinh d u o c ydu edu ehai sach rdng t r u d c khi kham.
TCNCYH 82 (2) - 2013
• T ^ P CHi NGHIEN CLPU Y HQC Khdm phdt hidn vd ddnh gid mire dp sdu rdng
trdn tdt ea cdc mdt rdng theo tidu chl ICDAS 11 [5], bao gdm ca tdn thuong sdu rang sdm vd ton thuong dd thdnh Id, sdu rdng nguydn phdt vd sdu rdng thir phdt Idn e|in midng trdm, Bdi vee-ni theo hudng ddn eua Td chirc sire khoe Thd gidi theo phdc dd 3 thdng/ldn trong 12 thdng,
Kiem sodt sai Idch thdng lin Hudn luydn kham sdu rang theo tidu ehi ICDAS II vd ddnh gid dp lin cay eua ba ngudi khdm sdu rdng Chi sd Kappa ehung cua ba ngudi khdm so vdl ngudi huan luydn Id 0,84 (0,88 - 0,86 - 0,77) Ty le kien dmh ciia ba ngudi khdm tuong ung Id 97%, 98% vd 96% Ngudi khdm khdng bidt ddi tuong duac khdm thudc nhdm thir nghidm ndo
Phuong phdp thu thdp du' lieu Tinh trang cua tdl ca cac rdng, mdt rdng duoe long hop, phdn tich dua trdn hai mire do
Si cdc tdn thuong s d m vd ton thuong thdnh Id d men vd nga (md sd 1, 2, 3, 4, 5, 6 theo ICDAS II),
S3 cae tdn thuong lien quan ddn ngd rdng (ma sd 4,5,6 theo ICDAS II. tuong duong mirc ddnh gid tdn thuong sdu ed Id theo lieu ehl WHO)
Cac chi sd ghi nhdn linh trang sdu rdng ly Id phdn trdm sdu rdng, ty Id phdn trdm giam sdu rdng, sd trung binh S,MT-R, S1MT-MR, trung binh S3MT-MR, S3MT-R, trung binh tdn thuong sdu rdng mdi d mirc S I vd S3
4. P h u a n g phap x i r ly s d lieu Phdn tich thdng ke sir dung phan mem SPSS phidn ban 20.0 Thdng ke md ta (ty Id phdn trdm sdu rdng, sd trung binh SiMT-R, S3MT-R. S,MT-MR, S3MT-MR) So sdnh ty Id phdn tram sdu rdng vd chi sd sdu mat trdm giua 3 nhdm bdng kidm dinh x^. kidm dinh Kruskal Wallis, kidm dinh Mann-Whitney Tat ca cdc phdp kidm d u o c dp dyng vdi dp tin cdy 95%
5. Oao dii'C n g h i e n cii'u
Nghidn eiru dup'c s u chdp thudn cua Hdi ddng Dgo dire trong nghidn cuu y sinh hoc.
Dgi hgc Y Duoe Thdnh phd Hd Chi Minh (Chirng nhdn sd 21/HDDD ngdy 5/10/2010)
III. K£T QUA
Nghidn eiru Ihyc hidn trdn 207 hpe sinh 12 tudi cua trudng trung hoe eo s d An Lac gdm 107 hpc sinh nam (52%) vd 100 hoc sinh nu' (48%), vdl ba nhdm: SCF dung Shellac F (65), s u dung Duraphal® (70) vd nhom chirng khdng sir dung vde-ni fluor (72)
Sau 12 thdng ddnh gid ede bidn sd nghien ciru bao gdm ty le sdu rdng todn bd, ty Id sdu rang mdi, mirc do giam sdu rang, chi sd sau mat trdm rdng vd sdu mat tram mdt rdng, mirc dd gia ldng ehi sd sau mdt tram rdng vd mat rang
Ty l e s a u rang
Bang 1 md ta ly Id Ire sdu rang a ede nhdm nghien eiru tai thdi didm ban ddu vd sau 12 thang Khdng cd s u khac bidt ed y nghTa giu'a 3 nhdm d ede thdi didm, ke ca khi xet tinh trang sau rang bao gdm ca cac tdn Ihuong sdu rdng mdi chdm (SI), hode ehi xet ede tdn thuong thanh Id (S3) (p > 0,05, kiem dinh x^)
Khi xdt tinh trang sdu rdng bao gdm ca edc ldn Ihuong sdu rang mdi chdm. ty Id sdu rdng mdi sau 12 thang d nhdm s u dung Shellac F vd Durphat® Id 60,0% va 64,3%, thdp hon so vdl nhdm chung khdng sir dung vdc-ni fluor (84,7%), khdc bidt cd y nghTa thdng kd (p < 0,01, kiem dinh x^) Khi chi xet ede tdn thuong thdnh Id, ty Id sdu rdng mdi sau 12 thdng d nhdm sir dung Shellac F vd Durphal®
Id 50,8% vd 4 7 , 1 % , thdp hon so vdi nhdm ehirng khdng sir dung vee-ni fluor (52,8%), tuy nhidn khde biel khdng ed y nghTa Ihdng ke (p > 0,05; kidm dinh x^) Khi so sanh ty le sau
ii^p CHl NGHISN CLKU Y HQC
rang a ba nhSm, ket qua cho th^y sau 12 ^6 mirc SI) vi 29% va 11% (ff mi>c S3) s thang mCrc (JO giam sau rang tirong Crng * vdi nhbm chCmg.
nhbm Shellac F va Duraphat* la 69% la 62%
Bang 1. Phan bd ty 1^ sSu rdng cua ba nhbm & thir\ di^m ban diiu va sau 12 thang
Nhbm
Shellac F (66) Duraphat* (70) Chu-ng (72)
Ban dilu n (%) 62 (95,4) 67 (96,7) 67(93,1)
8 1
12 thang n ( % ) 63(96,9) 69 (98,6) 72(100)
Ban dau n (%) 36 (55,4) 37 (52,9) 47 (65,3)
S3
12 thang n (%) 42 (64,6) 45 (64,3) 66 (76,4)
Chi s6 sau mat tram rang (SMT-R) va sau mat tram m$t rang (SMT-MR)
Bleu do 1 mb ta so trung binh mat rang sau mat tram cua ba nhbm thi> nghidm tai thbl diem bat dau nghien ctru, va sau 6 thang vi 12 thbng Sau 12 thang, so rang, mat rang sau mat tram trung binh b nhbm si> dung Shellac F vi Duraphal® thap hon so vbi nhbm chirng, khac bibt c6 y nghia thbng ke (p < 0,001, kiem dmh Mann-Whitney)
* T - ^ ^ c b r i n ^ f , . ' T 1G,6B
Bieu d6 1. Trung binh SiMT - MR cira ba nhom thCp nghiem tai cac thwi di^m Bieu do 2 mo ta so trung binh mat rang sau mat tram (S3IUIT - MR), khi xet a mirc sau rang thanh lb ciia ba nhbm thu' nghiem tai cac thbi diem nghiSn ciru So mat rang sau mat tram trung binh b nhbm sir dung Shellac F va Duraphal"thap hon so vbi nhbm chimg b ca thbi dilm danh gia sau 6 thang va 12 thang, tuy nhibn khac biet khbng cb y nghTa thbng ke (p > 0,05; kiem dmh Kruskal Wallis).
Khi xSt mirc db gia tang chi so sSu mat tram rang va mat rang, bao gom ca cac ton thmm mbi chbm, ket qua cho thiy ca hai nhbm Shellac F va Duraphal® cb mirc db gia tang chi so sau mat tram rang va mat rang thap hon so vbi nhbm chimg, khac bijt cb y nghTa b thbi diem 12 thang^ (p < 0,001, kiem dmh Mann-Whitney) Khbng cb khac biet cb y nghTa v i mu-c db gia tang chi so sau mat tram rang va mat rang khi chi xet ton thu'ong thanh lb (p > 0,05; kiem dinli Kruskal Wallis)
TCNCYH 82 (2) - 2013
• TAP CHi NGHI&N CLfU Y HOC
Ban dau Sau 6 Ihang Sau 12 Ihang
B i d u d d 2. T r u n g b i n h S3MT-MR c i i a ba n h d m t h i r n g h i e m tai cac t h d i d i e m
IV. BAN LUAN
Nghien eiru theo ddi hidu qua ngdn ehdn sdu rdng sau 12 thdng cua vde-ni Shellac F vd vec-ni Duraphal®, dp dung phdc dd bdi vdc-ni ba thang mdt ldn trdn hai nhdm thir nghidm can thidp, so sdnh vdi nhdm chirng khdng su' dung vdc-ni
Tinh trang sau rang bao g d m ca cac tdn t h u a n g sau rang m d i c h d m
Khi ddnh gid tinh trang sdu rdng theo lieu chi ICDAS II, sau 12 thdng, nhdm khdng si>
dung vec-ni cd 100% Ire bi sdu rdng, trong do 84,7% hoc sinh ed them it nhat 1 mdt rang sdu mdt tram mdi Ty Id ndy khde biel cd y nghTa thdng ke so vdi nhom Shellac F (60%) va nh6m Duraphal® (64,3%). {p = 0,003) Ty Id giam sdu rdng d nhdm Shellac F Id 69%
(p = 0,001) vd nhdm Duraphal® Id 62% {p = 0,005) so vdl nhdm chirng.
Chi sd sdu mdt trdm rdng vd sdu mat trdm mat rdng cua nhdm Shellac F vd nhbm Duraphal® ddu thdp hon so vdi nhdm ehdng d thdi didm 12 Ihdng (p < 0,01, p < 0,001). 0 nhdm ehirng, mirc dp su' gia tdng sd rdng vd mdt rdng sdu mdt trdm sau 12 thdng ddu cao hon so vdl hai nhdm su dung vdc-ni, khdc bidt CO y nghia thdng ke {p < 0,001) Ddng thdi, ty Id tre cd ldi thieu 3, 6 hodc 9 mat rdng sau mdi
sau 12 thdng d nhdm khdng du'oe sir dung vdc-ni fluor cung eao hon so vd; ede nhom sir dung vdc-nl fluor (p < 0,001), Kdl qua nghien ciru ung hp co chd tac dung cua vec-ni fluor trong viee ngdn ngira su- mat khoang, thiic ddy qua trinh tdi khoang, lam lang sire de khang vdi acid cua mo khoang hoa eua rang, ddc biet ddi vdi cae rang mdi moc va eae tdn thu'ong sdu rdng mdi ehdm
Khi so sdnh linh trang sdu rang 0 hai nhdm can thidp, khdng thdy cd khdc biet vd mirc do gia lang sd trung binh sdu mat tram mat rang giUa nhom su dung Shellac F vd nhdm sir dung Duraphal® (p = 0,302)
Khi so sdnh vdi kdt qua nghien ciru eua Arruda, danh gia tdc dung eua vee-ni Cavity Shield® NaF 5% trdn rdng vTnh vidn ciia 210 tre 6 ddn 14 tudi, sdng lai viing cd ngudn nu'de sinh hoat khdng bd sung fluor, eb nguy CO sau rdng cao, dp dung tieu ehl ICDAS II, ty le giam sdu rang sau 12 thdng eua nhom si>
dung vde-ni Shellac F dat 69%, eao hon so vdl ty le 49% {nhdm du'oc bdi vee-ni 2 ldn) va 3 1 % (nhdm chi bdi vec-ni 1 ldn) trong nghien edu eua Arruda [6] Bdn canh ydu td ve dae tinh eua vdl hdu, ldn sudt sir dung vee-ni eb thd Id mdt yeu id eo y nghia ddi vdi hieu qua cua vide sir dung cdc vdt lidu fluor tai chd vi vide ldp lai bdi vde-ni fluor khdng nhiJng gia
55
TAP CHi NGHIEN CO'U Y H p C •
tdng lu'ong fluor lu'u lai Idu ddi trdn bd mdt men rdng md edn gia tdng lu'png ion fluor kdt hpp trong cdc edu triic tmh the cua men rdng [7) Nhu- vdy, kdl qua ddnh gid linh Irpng sdu rdng d mire S1 theo tidu ehl ICDAS li cho thdy ea vde-ni Shellac F vd vdc-ni Duraphal® ddu cd hidu qua ngdn ngira sdu rdng tdl sau 12 thdng Trong nghidn ciru ndy, ndu ehi ddnh gid nhu'ng tdn thu'ong thdnh Id dd lidn tnen tdi ngd rdng, ehiing ta bd qua gan 50% hoc smh cd sdu rdng vd hpn 5 mdt rdng sdu rdng sdm,
Tinh trang sdu rang d mii'c tdn thu'O'ng da thanh Id
Ket qua khdm ldm sang d thdi didm bdt dau thd nghidm cho thdy ty Id trung binh tre CO sdu rang thdnh Id la 55%, khdng cd khde biet cb y nghTa vd ty le tre sdu rdng giira ba nhom (p - 0,285) Ty Id ndy lu'ong tu- vdi ket qua nghien ciru eua Tran Bich Vdn vd cdng SU' nam 2008 la 57,7% [8] Sau 12 thdng, ly Id sdu rang a cdc nhdm sir dung Shellac F, Duraphal® vd nhdm ehirng la 64,6%, 64,3%, vd 76,4%, khdng co khde biet ed y nghTa thdng k d ( p = 0,211)
Xet vd sd mdt rdng sdu mat trdm cua cac nhdm thu- nghiem, khdng cd khde biet cd y nghTa vd mirc dd gia ldng sd mdt rdng sdu mat trdm giu-a hai nhdm can thidp, mdc dd gia ldng sd mdt rdng sau mat trdm eua nhdm sir dung Shellac F vd nhdm sir dung Duraphal®
d thdi didm 6 thang Id 0,75 ± 1,32 vd 0,71 ± 1,30, sau 12 thdng la 1,21 ± 1,95 vd 1,52 ± 2,52
Nhdm sir dung vdc-ni Shellac F ed ty le giam sdu rang sau 12 thdng Id 29% so vdi nhdm chirng Ty Id ndy tu'ong lu' kdl qua nghien ciru cua Nguydn Thi Bgch Ciic vd edng SU' thu'c hien trdn 267 tre 6-8 tudi tai edc tru'dng lieu hoc qudn Thu Ddc, vdi ty Id giam sdu rang sau 18 thdng la 28,12% [9] Trong mdt thir nghiem lam sdng khde do Hoang Dao
Bao Trdm vd cdng su' thu'c hidn trdn 200 Ire tgi tru'dng tidu hoe Lu'ong Thd Vinh, qudn 7, ty 10 giam sdu rdng dgt du'oc khi theo ddi tren cdc rdng edi vTnh vidn thir nhdt sau 12 thdng SU' dung vdc-ni Shellac F Iheo phac dd 3 thdng mOt ldn Id 8 5 % [10]
Kdt qua ede nghidn ciru trdn thd gidi da cho thdy vdc-ni fluor cd hidu qua ngdn ngira Sdu rdng, vdi ty Id giam sdu rdng t d 20% d^n 70% so vdl nhdm chirng Trong dd, nhi^u nghidn eiru sir dyng vde-ni Duraphat*, dp dyng phdc do bdi vde-ni sdu thdng mdt ldn Sau hai ndm, ede kdt qua nghidn ciru deu cho thdy kha ndng ngdn ngira sdu rdng cua vgt hdu ndy, vdi ty Id giam sdu rdng 37% Seppd (1981) [11], 4 1 % (Zimmer, 1999) [12], 50%
(Weinlraub, 2006) [13], 3 5 % {Holve, 2008) [14], 18% {Lawrence, 2008) [15]
V. K^T LUAN
Thir nghiem cpng ddng, phdn nhdm ngiu nhidn, mu don, cd nhdm ehdng duoe thifc hidn trdn 207 Ire 12 tudi tai trodng trung hoc CO s d An Lae, qudn Binh Tdn, thdnh pho Ho Chi Minh, dp dung tieu ehi ICDAS 11 nh^m ddnh gid hieu qua eua vde-ni Shellac F trong ngdn ngira sau rdng Ket qua ddnh gid sau 12 thdng eho thay vde-ni Shellac F c6 hidu qua trong ngdn ngda sdu rdng vd hieu qua nay tu'ong du'ong vdc-ni Duraphat®
Lai cam e n Chdn thdnh cdm o n S d Khoa hoe vd Cong nghd thdnh phd H d Chi Minh, Khoa Rang Ham Mat - Dai hoe Y Du'oc thdnh phd Hi Chi Minh, ede thdnh vidn nhdm nghidn cifU, tru'dng trung hoe e o s d An Lac - Phu'dng An Lac, Qudn Binh T d n , thdnh phd Ho Chl Minh va ede em hpe smh dd tham gia d^tai nghidn eiru.
56 TCNCYH 82 (2) - 2013
• TAP CHf NGHIEN CU'U Y HpC
TAI LIEU THAM KHAO
1. Trdn Van Trirdng vd cs (2001). Didu tra sire khoe rdng midng Vidt Nam 2000. Nhd xudt ban Hd NOi
2. Ngd Ddng Khanh (2000). Tinh hinh sdc khde rdng midng Vidl Nam Vidn Rdng Hdm Mdt Trung u-ong Thanh phd Hd Chi Minh,
3. Dao Thj Hdng Quan va cs (2003) Tinh trang sdu rdng eua tre 12 vd 15 tudi lgi thdnh phd Hd Chi Minh sau 12 ndm fluor hda nu'de Tuydn tap cdng trinh nghi§n cifu khoa hoc RSng Ham MSt
4. Hoang Tie Hung va cs (2000). Nghidn cdu chd tao san pham phdng ngira bdnh sdu rdng tir nhu-a cdnh kidn do {Shellac) VSn bdn nghidm thu dd tai cdp B6 Y td. Dai hoc Y Dwac Thanh phd Hd Chl Mmh
5. International Caries Detection and Assessment System Coordinating Commit- tee (2005) Criteria Manual International Canes Detection and Assessment System (ICDAS II) Workshop held in Baltimore, Maryland
6. Arruda A.O., Senthamarai Kannan R., Inglehart M.R et al (2012). Effect of 5%
fluoride varnish application on canes among school children in rural Brazil a randomized controlled tnal Community Dent Oral Epidemiol 40, 267 - 276
7. Petersson i-.G., Arthursson •_., Ostberg C e t a l (1991). Caries inhibiting effect of different modes of Duraphat® varnish reapplicalion - a three year radiographic study Canes Res 25, 60 - 73.
8. T r i n Bich Van (2008). Tinh hinh sdu rang sau 1 ndm eua hoc sinh 12 ludi trirdng trung hoc eo so An Lac, qudn Binh Tdn, thdnh phd Hd Chi Minh vd cac ydu d anh hu'dng Ludn van tdt nghi6p Bac sT ngi tru. Dai hoc Y Dwac thanh phd Hd Chi Mmh
9. Nguydn Thj B^ch Cue va cs (2004).
Thu- nghi$m Idm sdng tdc dyng phdng chdng sdu rdng cua vdc-ni shellac ed fluor (Theo ddi trdn hoe sinh tidu hpc lai qudn Thu Oirc, thdnh phd Hd Chi Minh) Tuydn tip cdng trinh nghi§n ciru khoa hpc Rdng Hdm Mdt. D$i hoc Y DLy(?c Thdnh phd Hd Chl Mmh, 1 5 - 2 9
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TAP CHi NGHIEN Cl>U Y HQC
Summary
EFFICIENCY OF SHELLAC F VARNISH IN DENTAL CARIES PREVENTION IN 12 YEARS-OLD CHILDREN AFTER 12 MONTHS A single-blmd, randomized controlled trial was conducted in 207 children (12 years-old) living in a non-fluoridated area to evaluate the efficiency of Shellac F in dental caries prevention.
Shellac F and Duraphat® were applied in two experimental groups every 3 months, and no appli- cation of fluoride varnishes was done in the cpntrol group. Dental canes were evaluated according to the International Canes Detection and Assessment System (ICDAS 11) by 3 calibrated examin- ers. After 12 months, the mean scores of new carious teeth and teeth surfaces of the two experi- mental groups were significantly lower than that of the control group Ip < 0 05) in SI code There was no significant difference observed between the two expenmental groups (p > 0.05) However, the percentage of dental canes reduction was 29% in Shellac F and 11% in Duraphat* treated groups compared to the control groups (p < 0 05) This study demonstrated that Shellac F and Duraphat® were both effective in dental canes prevention in 12 years-old children after 12 months
Key words: fluoride varnish, Shellac F, caries prevention, ICDAS IIDAC DIEM LAM SANG VA K^T QUA HAN PHUC H 6 I T 6 N THLFaNG T 6 CHU'C CLPNG C 6 RANG KHONG DO SAU
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TCNCYH 82 (2) - 2013
