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Hom e > Vol 1, No 1 ( 2 01 2) > End ah furi
Efek Proteksi Biji M ahoni (Swietenia mahagoni
Jacq.) terhadap Kerusakan Hepar M encit yang
Diinduksi Parasetamol
Dah niar End ahfu ri, End ang List y an in gsih , Yu lia Sari
Abstract
Ba ckg rou nd : Seed of Swiet en ia m ahag on i Jacq . con t ains alkaloids, sap onins,
flav on oids, t rit erp enoid s, st eroid s, an d t ann in s wh ich were t h oug ht t o p rot ect liv er from f ree r ad icals.I n p resent st ud y , Swiet enia m ah agon y Jacq .seed ex t ract w as evaluat ed for it s pr ot ect ive eff ect on p aracet am ol- in d uced liv er d am ag e in m ice.
M e t ho ds:To evalu at e t h e hep at op rot ect iv e effect s of Swiet en ia m ahag on y Jacq.
seed ex t ract , 2 8 m ale Sw iss web st er m icewere eq u ally d iv id ed in t o four grou ps. An im als of g rou p I ( K) and g roup I I ( P1) were giv en aq uad est for 1 4 d ay s. Grou p I I I
( P2) receiv ed 1 4 m g/ 2 5 g bod y weig ht of m ice of Swiet en ia m ahag on y Jacq. seed
ext ract and t h e last g roup ( P3) received 2 8 m g / 2 5 g b ody w eigh t of m ice of
Sw iet enia m ah agon y Jacq . seed ext r act for 1 4 d ay s. Paracet am ol was g iv en t o g rou p s of P1, P2 , an d P3 .Mice were sacrif icedon t h e 15t h d ay an d hist ological
p rep arat ion was m ade t o ev alu at e hist olog ical dam age on liver. Liv er h ist ological feat ur es were assessed b y coun t in g t h e nu m ber of hep at ocy t e on cen t rolob uler zone u nd ergoing p yk n osis, k ary orh ex is, an d kary oly sis. Dat a were analy zed usin g t h e On eWay ANOVA test (α = 0.05) and then were continued with Post Hoc Mu lt iple Com p arisons ( LSD) test (α = 0.05).
Re sul t s:Th e m ean liv er hist ological dam age score was sig n ifican t ly h ig h er on g rou p
of P1= 6 0. 71 + 7 .5 21 , w hilegr ou p of K= 9 .8 6+ 1 .5 7 4 as t h e less.P2gr ou p had fewer
n um b ers of liv er hist ological dam age ( 3 2 .5 7+ 2 .5 7 3) com p ared t o t h e
P3grou p( 4 3 .5 7+ 3 .1 0 1) . Th e result s of OneWay ANOVA an d LSD t est sh owed t hat t h er e was sig nifican t d ifferen ce bet ween t he f ou r g rou ps ( p = 0. 00 0) .
Co ncl usio ns:Sw iet enia m ah agon y Jacq .seed ex t ract sh ow ed p rot ect iv e effect
again st t he h epat ot oxicit y ind uced b y paracet am olin m ice. Swiet en ia m ah ag ony Jacq.seed ex t ract w it h t h e dose of 1 4 m g/ 2 5 g bod yw eigh t of m ice showed a high er h ep at oprot ect iv e effect t han t h e dose of 2 8 m g / 2 5 g b ody w eigh t of m ice.
Ke y w ord s:Swiet en ia m ahag ony Jacq. seed , liv er d am ag e, paracet am ol
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