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ABSTRAK
Sirosis hati merupakan stadium lanjut dari fibrosis hati sebagai respon terhadap penyakit hati kronis. Hati memainkan peranan penting pada metabolisme lipid, beberapa tahap dalam sintesis dan transportasi lipid. Oleh karena itu, terdapat dugaan adanya kadar profil lipid yang abnormal pada disfungsi hati berat. Skor Child-Pugh telah diaplikasikan secara luas sebagai parameter prognostik pada pasien dengan sirosis hati.
Penelitian ini bertujuan untuk menentukan korelasi antara kadar profil lipid dengan derajat keparahan sirosis hati berdasarkan skor Child-Pugh.
Penelitian yang dilakukan merupakan penelitian analitik dengan pendekatan studi cross sectional. Pengambilan sampel dilakukan melalui metode
total sampling. Data diperoleh dari data sekunder rekam medis penderita sirosis hati di Departemen Ilmu Penyakit Dalam RSUP Haji Adam Malik Medan pada tahun 2014. Analisis data dilakukan secara univariat, bivariat, dan multivariat. Uji hipotesis dilakukan menggunakan uji korelasi Pearson atau uji alternatif korelasi
Spearman.
Berdasarkan hasil penelitian, terdapat 72 sampel sirosis hati yang memenuhi kriteria inklusi dengan rerata usia 51,22 ± 10,176 tahun. Perbandingan laki-laki dan perempuan adalah 2:1. Ada perbedaan yang bermakna antara rerata kadar profil lipid sampel dengan Child-Pugh A, B, dan C (p<0,05). Peningkatan skor Child-Pugh berkorelasi negatif dan secara statistik bermakna dengan penurunan kadar kolesterol total (p<0,001), trigliserida (p=0,001), HDL (p<0,001), dan LDL (p<0,001).
Dari penelitian ini dapat disimpulkan bahwa skor Child-Pugh pada pasien sirosis hati berkorelasi negatif bermakna dengan kadar profil lipid.
Kata Kunci : Sirosis Hati, Skor Child Pugh, Profil Lipid
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ABSTRACT
Liver cirrhosis is advanced stage of liver fibrosis in response to chronic liver injury. Liver plays an essential role in lipid metabolism, several stages of lipid synthesis and transportation. Therefore, it is reasonable to expect an abnormal lipid profile in those with severe liver dysfunction. Child-Pugh score have been the most widely applied prognostic markers in patients with liver cirrhosis.
This study aims to determine correlation between lipid profile levels with the severity of the liver cirrhosis by Child-Pugh score.
Research conducted an analytical study with cross-sectional study approach. Sampling was carried out through total sampling method. Data was obtained from secondary data of liver cirrhosis patients in the Department of Internal Medicine, Haji Adam Malik General Hospital Center – Medan in 2014. Data analysis is done as univariate, bivariate, and multivariate. Hypothesis testing is done using Pearson correlation test or Spearman correlation test as alternatives.
This study shows that there were 72 samples of liver cirrhosis met the inclusion criteria with the average age was 51,22±10,176 years. Male to female ratio were 2:1. There had difference between the mean of lipid profile levels of the samples with Child-Pugh A, B, and C (p<0,05). The increase in Child-Pugh score was inverse and statistically significant correlations with reduced levels in total cholesterol (p<0,001), triglyceride (p=0,001), HDL (p<0,001), and LDL (p<0,001).
From this study, it was found that Child-Pugh score in patients with liver cirrhosis has a significant negative correlation with lipid profile level.
Key words : Liver cirrhosis, Child Pugh score, Lipid profile
