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ABSTRAK
Kanker payudara tipe triple negatif adalah kanker payudara yang tidak mengekspresikan reseptor estrogen (ER), reseptor progesetron (PR) dan human epidermal growth factor receptor2 (HER-2). Kanker payudara triple negative (TNBC) mencakup 20-25% dari semua kanker payudara. Tumor-Infiltrating Lymphocytes (TILs) adalah satu tipe sel darah putih yang terdapat di tumor and fungsinya adalah untuk membunuh sel-sel tumor and ketampilannya sering diasosiasi dengan prognosis yang lebih baik.Tujuan penelitian ini adalah untuk melihat hubungan antara Tumor-Infiltrating Lymphocytes (TILs) dan grading histopatologi pada Triple Negative Breast Cancer.Penelitian ini merupakan penelitian analitik korelasi dengan desain cross sectional (potong lintang) dengan metode total sampling dan dilakukan di RSUP Haji Adam Malik Medan. Hasil penelitian dijumpai pasien terbanyak pada kelompok usia 50-59 tahun yaitu sebanyak 58,8%. Pasien Triple Negative Breast Cancer paling banyak dijumpai mempunyai grading histopatologi yang Grade II. Grading histopatologi terbanyak dijumpai pada status minimal Tumor-Infiltrating Lymphocytes (TILs) dan sebanyak 9 orang dengan grading histopatologi yang Grade II.
Kata Kunci: Triple Negative Breast Cancer, grading histopatologi, Tumor-Infiltrating Lymphocytes
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ABSTRACT
Triple Negative Breast Cancer is a type of breast cancer that does not express estragon receptors (ER), progesterone receptors and human-epidermal growth factor receptor (HER-2). Approximately 20-25% of all breast cancer patients has Triple negative breast cancer (TNBC) Tumour-Infiltrating Lymphocytes is a tye of white blood cells that exist around the tumour and functions to kill tumour cells and the existence of the cells are always correlated with better prognosis for the patients. The purpose of this is to observe the relationship between Tumour-Infiltrating Lymphocytes (TILs) and the histopatological grading of triple negative breast cancer. This research is an analytical type of research with a cross sectional design and using total sampling method which is done in RSUP Haji Adam Malik Medan Hospital. The total number of sample for this research is 17 patients. The result of this research concluded that the highest age group that was diagnosed with triple negative breast cancer is 50-59 years old which is at 58,8%. Histopatological grading of grade II is the most common with the triple negative breast cancer patient. Histopatological grading is most commonly found with minimal Tumour -Infiltrating lymphocytes (TILs) and with 9 patient with Grade II histopatological grading.
Keywords: Triple Negative Breast Cancer, histopatological grading, Tumour
-Infiltrating Lymphocytes(TILs)
