• Tidak ada hasil yang ditemukan

Berdasarkan hasil penelitian dan temuan penelitian ini, maka dapat disarankan:

1.   Perlu dilakukan penelitian lebih lanjut yang difokuskan terhadap mekanisme molekuler aktivitas antosianin secara langsung terhadap reseptor P2X4 mikroglia.

2.   Perlu dilakukan penilaian efek ekstrak air umbi ubi jalar ungu terhadap antioksidan enzimatis seperti SOD maupun GSH.

3.   Perlu dipertimbangkan evaluasi pemberian antosianin berdasarkan konsep pencegahan, yakni pemberian dilakukan pada hewan coba sebelum dilakukan CCI dan dievaluasi inisiasi, derajat, dan intensitas nyeri neuropatik yang muncul sesudahnya, dibandingkan dengan kelompok kontrol.

4.   Perlu dilakukan penilaian pengaruh ekstrak air umbi ubi jalar ungu terhadap kadar ATP ekstraseluler yang memicu ekspresi reseptor P2X4 pada permukaaan mikroglia. Pengukuran kadar ATP ekstraseluler sebelum dan sesudah perlakuan juga berguna sebagai parameter untuk membuktikan konsep pencegahan nyeri neuropatik.    

 

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