ﯽﯾﺎﻘﺑ زوﺮﻬﺑ ﯽﻠﺒﻠﺑ ﯽﻠﻌﻔﻄﻟ ،1
ﯽﻤﯿﮑﺣ يﺪﻬﻣ ،2
يدﺎﻫﺮﻓ ﻦﺴﺣ ،3 3
-1 ،ﯽﻠﯿﺑدرا ﻖﻘﺤﻣ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ ،ﺲﻔﻨﺗ و قوﺮﻋ ﺐﻠﻗ ﺶﯾاﺮﮔ ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ يﺮﺘﮐد يﻮﺠﺸﻧاد
ﻞﯿﺑدرا
-2 ،ﯽﻠﯿﺑدرا ﻖﻘﺤﻣ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ رﺎﯿﺸﻧاد ﻞﯿﺑدرا
-3 ،ﯽﻠﯿﺑدرا ﻖﻘﺤﻣ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ ،ﺲﻔﻨﺗ و قوﺮﻋ ﺐﻠﻗ ﺶﯾاﺮﮔ ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ يﺮﺘﮐد يﻮﺠﺸﻧاد
ﻞﯿﺑدرا -4 ،يﺮﺘﮐد يﻮﺠﺸﻧاد هوﺮﮔ
ﺖﯿﺑﺮﺗ ﯽﻧﺪﺑ و مﻮﻠﻋ
،ﯽﺷزرو هﺪﮑﺸﻧاد
مﻮﻠﻋ
،ﯽﻧﺎﺴﻧا ﺪﺣاو
،ﺮﻫا هﺎﮕﺸﻧاد دازآ
،ﯽﻣﻼﺳا
نﺎﺠﯾﺎﺑرذآ
،ﯽﻗﺮﺷ ناﺮﯾا
هﺪﯿﮑﭼ
ﺮﺛا ﯽﺳرﺮﺑ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ زا فﺪﻫ زﺎﻧﻮﺴﮐارﺎﭘ ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ
-
11 ﻞﯾﺎﻓوﺮﭘ و
هدﺮﮑﻧ ﻦﯾﺮﻤﺗ لﺎﺴﻧﺎﯿﻣ نادﺮﻣ يﺪﯿﭙﯿﻟ .دﻮﺑ
ﻪﮐ ﺪﻫد ﯽﻣ ﻞﯿﮑﺸﺗ ﺮﻫا نﺎﺘﺳﺮﻬﺷ لﺎﺴﻧﺎﯿﻣ نادﺮﻣ ار ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ يرﺎﻣآ ﻪﻌﻣﺎﺟ :ﻖﯿﻘﺤﺗ شور داﺮﻓا ﻦﯿﺑ زا ﺮﻔﻧ20
ﺘﻧا ﻖﯿﻘﺤﺗ رد ﺖﮐﺮﺷ ﺖﻬﺟ ﺐﻠﻃواد ﻪﯾﺎﭘ ﺖﻟﺎﺣ رد .ﺪﻧﺪﯾدﺮﮔ ﻢﯿﺴﻘﺗ لﺮﺘﻨﮐ و ﯽﺑﺮﺠﺗ هوﺮﮔ ود رد و هﺪﺷ بﺎﺨ
راﺪﻘﻣ ) ﻂﺳﻮﺘﻣ تﺪﺷ يزاﻮﻫ شزرو رد ﻦﯾﺮﻤﺗ هوﺮﮔ ﺲﭙﺳ .ﺪﺷ يﺮﯿﮔ هزاﺪﻧا يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ وPON1
ﻪﺴﻠﺟ3
ﻢﺘﺸﻫ ﻪﺘﻔﻫ نﺎﯾﺎﭘ زا ﺪﻌﺑ .ﺪﺷ ﻊﻨﻣ ﯽﺷزرو ﻢﻈﻨﻣ ﺖﯿﻟﺎﻌﻓ رد ﺖﮐﺮﺷ زا ﺰﯿﻧ لﺮﺘﻨﮐ هوﺮﮔ .ﺪﻧدﺮﮐ ﺖﮐﺮﺷ (ﻪﺘﻔﻫ ﺮﻫ رد زا .ﺪﺷ ﺬﺧا يﺪﯾرو نﻮﺧ ﻪﻧﻮﻤﻧ هوﺮﮔ ود ﺮﻫ
ﺢﻄﺳ ﻪﮐ داد نﺎﺸﻧ ﺶﻫوﮋﭘ يرﺎﻣآ يﺎﻫ ﯽﺳرﺮﺑ :ﺎﻫ ﻪﺘﻓﺎﯾ و LDL
ﺖﺷاد ﺶﻫﺎﮐ ﻦﯾﺮﻤﺗ هوﺮﮔ رد TG
) /05 0
≤ راﺪﻘﻣ ﻦﮑﯿﻟ ،(P وHDL
)ﺖﻓﺎﯾ يراد ﯽﻨﻌﻣ ﺶﯾاﺰﻓاPON1
/05 0
≤ حﻮﻄﺳ زا ﯽﺑﺮﺠﺗ هوﺮﮔ ﻦﯿﻨﭽﻤﻫ .(P
زا يﺮﺗﻻﺎﺑ وHDL
ﺮﺘﻤﮐ حﻮﻄﺳ وPON1
وTG
ردLDL
)ﺪﻧدﻮﺑ رادرﻮﺧﺮﺑ لﺮﺘﻨﮐ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ /05
0
≤ .(P
ﯽﻣﺮﺳ حﻮﻄﺳ ﺶﯾاﺰﻓا ﻖﯾﺮﻃ زا ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﻪﺘﻔﻫ ﺖﺸﻫ :يﺮﯿﮔ ﻪﺠﯿﺘﻧ وPON1
HDL
.دﻮﺷ ﯽﻣ هدﺮﮑﻧ ﻦﯾﺮﻤﺗ لﺎﺴﻧﺎﯿﻣ نادﺮﻣ رد دﻮﺷ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ ﺪﻧاﻮﺗ ﯽﻣ
زﺎﻧﻮﺴﮐارﺎﭘ :يﺪﯿﻠﮐ تﺎﻤﻠﮐ -
شزرو ،ﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ ،1
Abstract
Introduction: Aim of this research was the investigated of 8 week moderate aerobic exercise on Serum concentration of Paraoxonase-1 and Lipid Profile in middle-aged untrained men.
Methods: Statistical population this study was formed by untrained the middle-aged men of Ahar city. 20 of the volunteers were selected for the study and were divided into control and experimental groups. Paraoxonase-1 and Lipid Profile concentration Measured in basal state.
Then, experimental group’s participated in 8 week aerobic moderate exercise (three sessions per week). The control group was prevented from participating in regular physical activity.
After 8 week blood sample were taken both groups.
1 Paraoxonase-1 (PON1)
ﯽﺷزرو ﻪﯾﺬﻐﺗ و يژﻮﻟﻮﯾﺰﯿﻓ
Result: Statically analyze of this study was showed a significant reduction of TG and LDL and significant increases of HDL and PON1 in experimental group (P≤0.05). Also, experimental group compared with control group had a high level of HDL and PON1 and lower level of TG and LDL (P≤0.05).
Conclusion: 8 week aerobic moderate exercise via increases of HDL and PON1 concentration can lead to reduce of oxidative stress in untrained men.
Key words: Paraoxonase-1, Lipid Profile, Exercise ﻪﻣﺪﻘﻣ
ﯽﻣ نﺎﺸﻧ ﺎﻫ ﯽﺳرﺮﺑ ﻦﯾا زا ﯽﻤﯿﻧ زا ﺶﯿﺑ و ﺖﺳا ﺶﯾاﺰﻓا لﺎﺣ رد ﻒﻠﺘﺨﻣ يﺎﻫرﻮﺸﮐ رد لﺎﺴﻧﺎﯿﻣ ﺖﯿﻌﻤﺟ ﻪﮐ ﺪﻫد
ﺪﻨﻨﮐ ﯽﻣ ﯽﮔﺪﻧز ﻪﻌﺳﻮﺗ لﺎﺣ رد يﺎﻫرﻮﺸﮐ رد داﺮﻓا )
(1 هاﺮﻤﻫ يدﺪﻌﺘﻣ تﻼﮑﺸﻣ ﺎﺑ ﻦﺳ ﺶﯾاﺰﻓا لﺎﺣ ﻦﯾا ﺎﺑ .
ﺖﺳا . تﺎﻌﻟﺎﻄﻣ ﻪﮐ يﻮﺤﻧ ﻪﺑ ﯽﺘﺳﻮﭘ ﺮﯾز ﯽﺑﺮﭼ ﺖﻓﺎﺑ ﺶﯾاﺰﻓا و ﯽﻧﻼﻀﻋ ﺖﻓﺎﺑ ﺶﻫﺎﮐ ﺖﻠﻋ ﻪﺑ ﺪﻫد ﯽﻣ نﺎﺸﻧ
،
راﺪﻘﻣ ،LDL
راﺪﻘﻣ و ﺶﯾاﺰﻓا لﺎﺴﻧﺎﯿﻣ داﺮﻓا لوﺮﺘﺴﻠﮐ وTG
ﺎﻬﻧآHDL
دﺎﺠﯾا ﻪﺑ ﺮﺠﻨﻣ ﻪﮐ ﺪﻨﮐ ﯽﻣ اﺪﯿﭘ ﺶﻫﺎﮐ
ﻒﻠﺘﺨﻣ يﺎﻫ يرﺎﻤﯿﺑ دﻮﺷ ﯽﻣ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ زا ﯽﺷﺎﻧ
) (. 2 نﺎﯿﻣ ﻦﯾا رد ﺶﻘﻧ ﻖﯿﻗد ﻢﺴﯿﻧﺎﮑﻣ ﺪﻨﭼ ﺮﻫ
ردHDL
ﺶﯾاﺰﻓا ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ ﺎﻣا ﺖﺳا هﺪﺸﻧ ﺺﺨﺸﻣ ﯽﻨﺷور ﻪﺑ ﯽﻗوﺮﻋ و ﯽﺒﻠﻗ يﺎﻫ يرﺎﻤﯿﺑ ﺶﻫﺎﮐ
HDL-c
ﺮﺑ هوﻼﻋ
،ﺪﺒﮐ ﻪﺑ ﺎﻫ ﯽﺑﺮﭼ سﻮﮑﻌﻣ لﺎﻘﺘﻧا ﺮﺛا
ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ8
زﺎﻧﻮﺴﮐارﺎﭘ -
ﻞﯾﺎﻓوﺮﭘ و1 هدﺮﮑﻧ ﻦﯾﺮﻤﺗ لﺎﺴﻧﺎﯿﻣ نادﺮﻣ يﺪﯿﭙﯿﻟ
ﺪﻧاﻮﺗ ﯽﻣ
LDL-c
دﺎﺠﯾا زا و هدﺮﮐ ﺖﻈﻓﺎﺤﻣ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺐﯿﺳآ ﻞﺑﺎﻘﻣ رد ار يﺮﯿﮔﻮﻠﺟ هﺪﺷ هﺪﯿﺴﮐاLDL
ﺪﻨﮐ ) (3 ﯽﻧاﺪﯿﺴﮐا ﯽﺘﻧآ ناﻮﺗ دﺎﺠﯾا رد ﯽﻠﺻا ﻞﻣﺎﻋ لﺎﺣ ﻦﯾا ﺎﺑ . زﺎﻧﻮﺴﮐارﺎﭘ ﻢﯾﺰﻧآ ارHDL
- راد هﺪﻬﻋ ﺮﺑ 1 .د
زﺎﻧﻮﺴﮐارﺎﭘ -
ﺎﺑ ﻪﮐ ﺪﺷﺎﺑ ﯽﻣ ﺎﻫزﺎﻧﻮﺴﮐارﺎﭘ هداﻮﻧﺎﺧ زا ﻢﯿﺴﻠﮐ ﻪﺑ ﻪﺘﺴﺑاو زاﺮﺘﺳا مﺮﺳ ﮏﯾ1 ﻦﯾا .ددﺮﮔ ﯽﻣ ﺪﻧﺎﺑHDL
ﻞﯿﮑﺸﺗ زا يﺮﯿﮔﻮﻠﺟ رد ﯽﻤﻬﻣ ﺶﻘﻧ و هﺪﺷ ﺪﯿﻟﻮﺗ ﺪﺒﮐ رد ﻢﯾﺰﻧآ دراد هﺪﺷ هﺪﯿﺴﮐاLDL
) (4 . ﺮﮕﯾد ﯽﻓﺮﻃ زا
رد ﻪﮐ ﺖﺳا هﺪﺷ ﺺﺨﺸﻣ ﯽﻟﺎﺴﻧﺎﯿﻣ نارود
ﺶﻫﺎﮐ ﺎﺑ ﻮﺴﻤﻫ راﺪﻘﻣ ،HDL
PON-1
ﺶﻫﺎﮐ ﺰﯿﻧ ﺪﺑﺎﯾ ﯽﻣ
) (5 . ﺮﻫ
ﺪﻨﭼ رد يزاﻮﻫ يﺎﻫ ﺖﯿﻟﺎﻌﻓ صﻮﺼﺨﺑ ،ﯽﺷزرو ﻢﻈﻨﻣ ﺖﯿﻟﺎﻌﻓ ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ دﻮﺒﻬﺑ
ﺪﻨﺷﺎﺑ ﺮﺛﻮﻣ ﺪﻨﯾاﺮﻓ ﻦﯾا )
(6 . ﺎﺑ
لﺎﺣ ﻦﯾا و يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ حﻮﻄﺳ ﻪﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ
ﻞﯿﻟد ﻪﺑ ﻦﯿﻨﭽﻤﻫ و ﺪﻧﺮﯿﮔ ﯽﻣ راﺮﻗ ﻦﺳ ﺮﯿﺛﺎﺗ ﺖﺤﺗPON1
،لﺎﺴﻧﺎﯿﻣ داﺮﻓا رد ﯽﺗﺎﻘﯿﻘﺤﺗ يﺎﻫ ﺖﯾدوﺪﺤﻣ ﺎﺑ يزاﻮﻫ ﺖﯿﻟﺎﻌﻓ ﻪﺘﻔﻫ ﺖﺸﻫ ﺮﯿﺛﺎﺗ ﯽﺳرﺮﺑ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ زا فﺪﻫ
ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ تﺪﺷ
PON-1
، وHDL
.ﺪﺷﺎﺑ ﯽﻣ كﺮﺤﺗ ﻢﮐ لﺎﺴﻧﺎﯿﻣ نادﺮﻣ ردLDL
شور ﯽﺳﺎﻨﺷ ﻖﯿﻘﺤﺗ
ﺑﺮﺠﺗ ﻪﻤﯿﻧ عﻮﻧ زا ﺮﺿﺎﺣ ﺶﻫوﮋﭘ نادﺮﻣ ار نآ يرﺎﻣآ ﻪﻌﻣﺎﺟ ﻪﮐ ﺖﺳا ﯽ
-42 .ﺪﻫد ﯽﻣ ﻞﯿﮑﺸﺗ ﺮﻫا ﺮﻬﺷ لﺎﺳ35
لﺎﺳ نﺎﺘﺴﻣز و ﺰﯿﯾﺎﭘ رد ﻪﺘﻓﺮﮔ ترﻮﺻ ناﻮﺧاﺮﻓ ﯽﻃ ،1393
زا ﺪﻌﺑ .ﺪﻧﺪﺷ ﻖﯿﻘﺤﺗ رد ﺖﮐﺮﺷ ﺐﻠﻃواد ﺮﻔﻧ50
داﺪﻌﺗ ،ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ يﺎﻫ ﺺﺧﺎﺷ يﺮﯿﮔ هزاﺪﻧا و ﻖﯿﻘﺤﺗ رد ﺖﮐﺮﺷ ﻪﻣﺎﻧ ﺖﯾﺎﺿر مﺮﻓ ﻞﯿﻤﮑﺗ ﺰﺋﺎﺣ ﻪﮐ ﺮﻔﻧ20
ﮐﺮﺷ ﻂﯾاﺮﺷ بﺎﺨﺘﻧا ﺪﻨﻤﻓﺪﻫ ترﻮﺼﺑ ﺪﻧدﻮﺑ ﻖﯿﻘﺤﺗ رد ﺖ
ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ لﺮﺘﻨﮐ و ﻦﯾﺮﻤﺗ هوﺮﮔ ود رد و ﻦﯿﻨﭽﻤﻫ .
زﺎﻧﻮﺴﮐارﺎﭘ ﯽﻣﺮﺳ راﺪﻘﻣ ﯽﺳرﺮﺑ ﺖﻬﺟ يﺪﯾرو نﻮﺧ ﻪﻧﻮﻤﻧ ﻪﯾﺎﭘ ﺖﻟﺎﺣ رد -
و 1
ﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ
ﺲﭙﺳ .ﺪﯾدﺮﮔ ﺬﺧا
ﺎﻫ ﯽﻧدﻮﻣزآ ﻦﯾﺮﻤﺗ هوﺮﮔ ي
ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﻪﻣﺎﻧﺮﺑ رد ﺎﺑ يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ ﻞﻣﺎﺷ ﻪﮐ يا ﻪﺘﻔﻫ8
تﺪﺷ -70 ﺪﺻرد55
.ﺪﻧدﺮﮐ ﺖﮐﺮﺷ دﻮﺑ ﻪﻨﯿﺸﯿﺑ ﺐﻠﻗ نﺎﺑﺮﺿ ﺮﺜﮐاﺪﺣ ﻢﻈﻨﻣ يﺎﻫ ﺖﯿﻟﺎﻌﻓ رد ﺖﮐﺮﺷ زا لﺮﺘﻨﮐ هوﺮﮔ تﺪﻣ ﻦﯾا رد
.ﺪﻧﺪﺷ ﻊﻨﻣ ﯽﺷزرو راﺪﻘﻣ ﻦﯿﻨﭽﻤﻫ و ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ يﺎﻫ ﺺﺧﺎﺷ تاﺮﯿﯿﻐﺗ ﻢﺘﺸﻫ ﻪﺘﻔﻫ نﺎﯾﺎﭘ رد
PON-1
ﻞﯾﺎﻓوﺮﭘ و
ﺪﯿﭙﯿﻟ .ﺪﺷ يﺮﯿﮔ هزاﺪﻧا
ﻮﻣزآ زا ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ رد ،ﻦﯾا ﺮﺑ هوﻼﻋ فوﺮﮔﻮﻤﻠﮐ ن
- زا ﻦﯿﻨﭽﻤﻫ و ﺎﻫ هداد ﯽﻌﯿﺒﻃ ﻊﯾزﻮﺗ ﻦﯿﯿﻌﺗ ﺖﻬﺟ ﻒﻧﺮﯿﻤﺳا
.ﺪﺷ هدﺎﻔﺘﺳا ﺎﻫ ﺺﺧﺎﺷ ﯽﻫوﺮﮔ ﻦﯿﺑ و ﯽﻫوﺮﮔ نورد تاﺮﯿﯿﻐﺗ ﯽﺳرﺮﺑ ﺖﻬﺟ ﻞﻘﺘﺴﻣ ﯽﺗ و ﯽﺟوز ﯽﺗ يﺎﻫ نﻮﻣزآ يراد ﯽﻨﻌﻣ ﺢﻄﺳ رد ﺎﻫ هداد ﯽﻣﺎﻤﺗ /05
0
≤ راﺰﻓا مﺮﻧ زا هدﺎﻔﺘﺳا ﺎﺑP
ﻪﺨﺴﻧSPSS
و22
Excel
ﻪﺨﺴﻧ 2010
درﻮﻣ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﯽﺳرﺮﺑ
ﺎﻫ ﻪﺘﻓﺎﯾ
راﺪﻘﻣ ﻪﮐ داد نﺎﺸﻧ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ يرﺎﻣآ يﺎﻫ ﯽﺳرﺮﺑ وPON1
ﻪﺘﻔﻫ ﺖﺸﻫ ﺮﺛا رد ﻦﯾﺮﻤﺗ هوﺮﮔ ردHDL
) ﺖﺷاد يراد ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ /05
0
≤ راﺪﻘﻣ ﻦﯿﻨﭽﻤﻫ .(P وLDL
ﺶﻫﺎﮐ هوﺮﮔ ﻦﯾا رد ﺰﯿﻧTG
) ﺖﻓﺎﯾ يراد ﯽﻨﻌﻣ /05
0
≤ يراد ﯽﻨﻌﻣ ﺮﯿﯿﻐﺗ لﺮﺘﻨﮐ هوﺮﮔ رد .(P ) ﺪﺸﻧ هﺪﻫﺎﺸﻣ
/05 0
≥ .(P
لوﺪﺟ و (ﺮﺘﯿﻟ ﯽﺴﯾد ﺮﺑ مﺮﮔ ﯽﻠﯿﻣ) ﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ تاﺮﯿﯿﻐﺗ .1 )PON1
nmol/min/ml
(
لﺮﺘﻨﮐ و ﯽﺑﺮﺠﺗ هوﺮﮔ رد
ﺧﺎﺷ ص ﯽﺑﺮﺠﺗ هوﺮﮔ
نوردP ﯽﻫوﺮﮔ لﺮﺘﻨﮐ هوﺮﮔ
نوردP ﯽﻫوﺮﮔ ﻦﯿﺑP ﯽﻫوﺮﮔ
ﻢﺘﺸﻫ ﻪﺘﻔﻫ ﻪﯾﺎﭘ ﻢﺘﺸﻫ ﻪﺘﻔﻫ ﻪﯾﺎﭘ
LDL -C
/45 4
± /2 106 /07 7
± /2 91 /032
0 /17 3
± /4
107 /14
2
± /4 109 /877
0 /001
0
TG
/5 2
± /33 107 /1 7
± /56 80 /009
0 /4 2
± /22
106 /66
1
± /14
110 /412
0 /001
0
HDL -c
/03 2
± /1 51 /12 3
± /4 57 /049
0 /66 1
± /05
51 /88
0
± /2 50 /899
0 /022
0
PON 1
/44 1
± /067
152 /87
0
± /055
154 /004
0 /09 2
± /55
152 /002
0
± /32
152 /999
0 /001
0
ﻪﺠﯿﺘﻧ و ﺚﺤﺑ يﺮﯿﮔ
راد ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ ﺖﺸﻫ ﻪﮐ داد نﺎﺸﻧ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ يرﺎﻣآ ﯽﺳرﺮﺑ
HDL-C
و
راد ﯽﻨﻌﻣ ﺶﻫﺎﮐ
LDL-c
و تﺎﻨﯾﺮﻤﺗ ﺮﯿﺛﺎﺗ ﺮﺑ ﯽﻨﺒﻣ ﻦﯿﻘﻘﺤﻣ زا ﯽﺧﺮﺑ يﺎﻫ ﻪﺘﻓﺎﯾ ﺎﺑ ﺎﻫ ﻪﺘﻓﺎﯾ ﻦﯾا .دﻮﺷ ﯽﻣTG
ﺶﻫﺎﮐ رد يزاﻮﻫ
LDL-c
و ﺶﯾاﺰﻓا وTG HDL-c
دراد ﯽﻧاﻮﺨﻤﻫ )
,7 (8 يﺎﻫ ﺖﯿﻟﺎﻌﻓ ياﺮﺟا ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ .
ﻢﯾﺰﻧآ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ يزاﻮﻫ ﯽﺷزرو ﺶﻫﺎﮐ وLPL
ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﻪﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .دﻮﺷ ﯽﻣHTGL
ناﺰﯿﻣ اﺬﻟ ،ﺪﻫد ﯽﻣ ﺶﯾاﺰﻓا ار ﺪﯾﺮﯿﺴﯿﻠﮔ يﺮﺗ زا ﯽﻨﻏ يﺎﻫ ﻦﯿﺌﺗوﺮﭘﻮﭙﯿﻟ ﻢﺴﯿﻟﻮﺑﺎﺗﺎﮐ ،LPL
ﺖﯿﻟﺎﻌﻓ ياﺮﺟا ﺎﺑLDL
ﺪﺑﺎﯾ ﯽﻣ ﺶﻫﺎﮐ ﯽﻧﺪﺑ يﺎﻫ )
(8 تاﺮﯿﯿﻐﺗ ﻢﺴﯿﻧﺎﮑﻣ لﺎﺣ ﻦﯾا ﺎﺑ .
HDL-c
ﻪﺑ هﺪﯿﭽﯿﭘ يا هزاﺪﻧا ﺎﺗ يزاﻮﻫ ﺖﯿﻟﺎﻌﻓ ﺮﺛا رد
) زﺎﭙﯿﻟ ﻦﯿﺌﺗﻮﭘﻮﭙﯿﻟ يﺎﻫ ﻢﯾﺰﻧآ ﻪﮐ ﺖﺳا هداد نﺎﺸﻧ ﺎﻫ ﯽﺳرﺮﺑ .ﺪﺳر ﯽﻣ ﺮﻈﻧ ﭙﯿﻟ ،(LPL
) ﺪﯾﺮﯿﺴﯿﻠﮔ يﺮﺗ يﺪﺒﮐ زﺎ (HL
ﻞﯾﺮﺘﺴﻠﮐ ﺮﺘﺳا ﻞﻣﺎﺣ ﻦﯿﺌﺗوﺮﭘ و )2
ﺖﻈﻠﻏ ﺮﯿﯿﻐﺗ رد ﯽﻤﻬﻣ ﺶﻘﻧ (CETP HDL-c
ﻢﯾﺰﻧآ .ﺪﻨﻨﮐ ﯽﻣ يزﺎﺑ زاLPL
2 Cholesteryl ester transfer protein
ﺖﻈﻠﻏ ﺮﯿﯿﻐﺗ رد ﻞﻣﺎﻋ ﻦﯾﺮﺘﻤﻬﻣ ﺎﻤﺳﻼﭘ ﺪﯾﺮﯿﺴﯿﻠﮔ يﺮﺗ ﺰﯿﻟورﺪﯿﻫ ﻖﯾﺮﻃ لﺎﺣ ﻦﯾا ﺎﺑ .دﻮﺷ ﯽﻣ بﻮﺴﺤﻣHDL
ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﺶﯾاﺰﻓا لﻮﺌﺴﻣ ﯽﯾﺎﻬﻨﺗ ﻪﺑLPL
HDL-c
و هدﻮﺒﻧ ﻦﯾﺮﻤﺗ ﺮﺛا رد ﻦﯾا رد ﯽﻤﻬﻣ ﺶﻘﻧ ﺰﯿﻧCETP
.دراد ﺪﻨﯾاﺮﻓ لﻮﮑﻟﻮﻣ رد ﺎﻫ ﯽﺑﺮﭼ ﻞﻤﺣ لﻮﺌﺴﻣCETP
HDL-c
ﺮﺛا رد ﻪﮐ دراد هﺪﻬﻋ ﺮﺑ ار ﺎﻫ ﻦﯿﺌﺗوﺮﭘﻮﭙﯿﻟ ﺮﯾﺎﺳ و
ﺪﻨﮐ ﯽﻣ اﺪﯿﭘ ﺶﻫﺎﮐ نآ راﺪﻘﻣ تﺎﻨﯾﺮﻤﺗ )
,9 ( .10
ﻦﯿﺑ طﺎﺒﺗرا لﺎﺣ ﻦﯾا ﺎﺑ
HDL-c
و
PON1
ﺶﯾاﺰﻓا ﻪﮑﯾرﻮﻃ ﻪﺑ .ﺖﺳا رﺎﯿﺴﺑ ﺖﯿﻤﻫا ﺰﺋﺎﺣ ﺰﯿﻧ
HDL-c
ﻪﺑ ﺮﺠﻨﻣ
ﺶﯾاﺰﻓا ﺶﯾاﺰﻓا وPON1
ﺶﯾﺎﺴﮐا ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣPON1
ﺖﯿﻟﺎﻌﻓ دﻮﺒﻬﺑ ﺰﯿﻧ وLDL HDL-c
دﻮﺷ ﯽﻣ ) (2 رد .
ﺤﺗ راد ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ يزاﻮﻫ ﺖﯿﻟﺎﻌﻓ ﻪﺘﻔﻫ ﺖﺸﻫ ﻪﮐ ﺪﺷ ﺺﺨﺸﻣ ﺮﺿﺎﺣ ﻖﯿﻘ لﺎﺣ ﻦﯾا ﺎﺑ .دﻮﺷ ﯽﻣPON1
ﺮﺑ ﻢﻈﻨﻣ يزاﻮﻫ شزرو ﺮﺛا درﻮﻣ رد ﻪﺘﻓﺎﯾ زا ﯽﺧﺮﺑ ﻪﮑﯾرﻮﻄﺑ ،دراﺪﻧ دﻮﺟو ﻦﯿﻘﻘﺤﻣ ﻦﯿﺑ رد ﯽﻧﺎﺴﮑﯾ هﺎﮔﺪﯾدPON1
ﺶﯾاﺰﻓا ﻪﺑ ﺎﻫ ﺪﻧراد هرﺎﺷا نآ ﺶﻫﺎﮐ ﻪﺑ ﯽﺧﺮﺑ وPON1
) ,11 (12 ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ لﺎﺣ ﻦﯾا ﺎﺑ . ﺖﺤﺗPON1
ﻦﯿﻨﺳ رد ﻻﺎﻤﺘﺣا و ﯽﮐدﻮﮐ رد و نآ ﺪﺣ ﻦﯾﺮﺘﺸﯿﺑ ﯽﻧاﻮﺟ ﻦﯿﻨﺳ رد ﻪﮑﯾرﻮﻄﺑ ،دﺮﯿﮔ ﯽﻣ راﺮﻗ داﺮﻓا ﻦﺳ ﺮﯿﺛﺎﺗ ﻢﯿﺘﺴﻫ وﺮﺑور نآ ﺶﻫﺎﮐ ﺎﺑ ﯽﻟﺎﺴﻧﺎﯿﻣ )
(13 ﺮﯾدﺎﻘﻣ ﺰﯿﻧ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ حﻮﻄﺳ نﻮﭽﻤﻫ يﺮﮕﯾد ﻞﻣاﻮﻋ ﺪﻨﭼ ﺮﻫ .
ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺶﯾاﺰﻓا ﺖﺳا هﺪﺷ شراﺰﮔ ﻪﯿﮐرﻮﻄﺑ .ﺪﻫد ﯽﻣ راﺮﻗ ﺮﯿﺛﺎﺗ ﺖﺤﺗ ارPON1 PON1
دﻮﺷ ﯽﻣ ) (13 ﺶﯾاﺰﻓا ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ اﺬﻟ . ﯽﺷﺎﻧ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺶﻫﺎﮐ ﻞﯿﻟد ﻪﺑ ﻻﺎﻤﺘﺣا ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ ردPON1
.ﺪﺷﺎﺑ يزاﻮﻫ ﺖﯿﻟﺎﻌﻓ زا
ﻊﺑﺎﻨﻣ
1- Buttaro TM, Koeniger-Donohue R, Hawkins J. Sexuality and quality of life in aging:
implications for practice. The Journal for Nurse Practitioners. 2014; 10(7): 480-5.
2- Goh VH, Tong TY, Mok HP, Said B. Differential impact of aging and gender on lipid and lipoprotein profiles in a cohort of healthy Chinese Singaporeans. Asian journal of andrology. 2007;
9(6): 787-94.
3- Wang Z, Nakayama T. Inflammation, a link between obesity and cardiovascular disease.
Mediators of inflammation. 2010; 2010.
4- Grdic Rajkovic M, Rumora L, Barisic K. The paraoxonase 1, 2 and 3 in humans. Biochemia medica. 2011; 21(2): 122-30.
5- Marchegiani F, Marra M, Olivieri F, Cardelli M, James RW, Boemi M, et al. Paraoxonase 1:
genetics and activities during aging. Rejuvenation research. 2008; 11(1): 113-27.
6- Turgay F, Şişman AR, Aksu AÇ. Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype. Journal of atherosclerosis and thrombosis. 2015; (0.(
7- Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism.
2007; 56(4): 444-50.
8- Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Medicine. 2014; 44(2): 211-21.
9- Warren A, Howden EJ, Williams AD, Fell JW, Johnson NA. Postexercise fat oxidation: effect of exercise duration, intensity, and modality. International journal of sport nutrition. 2009; 19(6): 607.
10- Park S-K, Park J-H, Kwon Y-C, Yoon M-S, Kim C-S. The effect of long-term aerobic exercise on maximal oxygen consumption, left ventricular function and serum lipids in elderly women. Journal of physiological anthropology and applied human science. 2003.7 -11 :(1)22 ;
11- Tomás M, Elosua R, Sentí M, Molina L, Vila J, Anglada R, et al. Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity. Journal of lipid research. 2002; 43(5): 713-20.
12- Otocka-Kmiecik A, Orłowska-Majdak M. The role of genetic (PON1 polymorphism) and environmental factors, especially physical activity, in antioxidant function of paraoxonase Udział czynników genetycznych (polimorfizm PON1) i środowiskowych, a zwłaszcza aktywności fizycznej, w procesie antyoksydacyjnego działania paraoksynazy. Journal cover. 2015; 69.
ﯿﺋوﺮﺘﺳا فﺮﺼﻣءﻮﺳ زا ﯽﺷﺎﻧ رﺎﺛآ ﯽﺳرﺮﺑ ﮏﯿﻟﻮﺑﺎﻧآ يﺎﻫﺪ
- ﯽﻣﺮﺳ ﮏﯾژﻮﻟﻮﺗﺎﻤﻫ ﺮﺑ ﮏﯿﻧژورﺪﻧآ
ماﺪﻧا شروﺮﭘ ﻪﺘﺷر رﺎﮑﺷزرو نادﺮﻣ رد ﻞﯿﻤﺟ ﯽﮐﺎﺤﺿﺮﻬﭼﻮﻨﻣ ﺎﯿﻧ ﯽﻧﺎﻤﺣر دﺎﻫﺮﻓ ﺮﺘﮐد ،1
2
- 1 ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﺪﺷرا سﺎﻨﺷرﺎﮐ .ناﺮﯾا ،ﺖﺷر ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ ،ﺖﺷر ﺪﺣاو ،ﯽﻣﻼﺳا دازآ هﺎﮕﺸﻧاد
- 2 نﻼﯿﮔ هﺎﮕﺸﻧاد دﺎﺘﺳا
هﺪﯿﮑﭼ
ﻪﺘﺷر نارﺎﮑﺷزرو رد ﯽﻧﻮﺧ ﻞﻣاﻮﻋ ﺮﺑ ﺎﻫﺪﯿﺋوﺮﺘﺳا فﺮﺼﻣءﻮﺳ زا ﯽﺷﺎﻧ رﺎﺛآ ﯽﺳرﺮﺑ ،ور ﺶﯿﭘ ﻖﯿﻘﺤﺗ زا فﺪﻫ هﺪﻧﺮﯿﮔﺮﺑ رد و ،ﺖﺳا يداﺪﯾور ﺲﭘ عﻮﻧ زا ﺮﺿﺎﺣ ﺶﻫوﮋﭘ .ﺪﺷﺎﺑ ﯽﻣ ماﺪﻧا شروﺮﭘ ﻪﺘﺷر رﺎﮑﺷزرو دﺮﻣ48
ﻦﺳ) ماﺪﻧا شروﺮﭘ /73
4
± /02 ﺐﻟﺎﻗ رد ﻪﮐ .ﺪﺷﺎﺑ ﯽﻣ (لﺎﺳ 25 فﺮﺼﻣ لﺎﺣ رد نارﺎﮑﺷزرو ﻞﻣﺎﺷ هوﺮﮔ3
) =16
n1
( فﺮﺼﻣ زا يرود هﺎﻣ ﻪﺳ و ﻪﻘﺑﺎﺳ ﺎﺑ ، )
=16
n2
) ﺪﯿﺋوﺮﺘﺳا فﺮﺼﻣ ﻪﻘﺑﺎﺳ نوﺪﺑ و ( =16
n3
.ﺪﻨﺘﻓﺮﮔ راﺮﻗ (
و ﯽﺠﻨﺳﺮﮑﯿﭘ يﺎﻫ يﺮﯿﮔ هزاﺪﻧا زا ﺲﭘ زا ﺲﭘ ﯽﻧﻮﺧ يﺎﻫ ﻪﻧﻮﻤﻧ ،1RM
ﯾﺎﺘﻧ .ﺪﻧﺪﺷ ﻪﯿﻬﺗ ،ﯽﯾﺎﺘﺷﺎﻧ ﺖﻋﺎﺳ12 ،ﺞ
توﺎﻔﺗ مﻮﺳ و مود هوﺮﮔ ﻦﯿﺑ ﻪﮐ دﻮﺑ مﻮﺳ و لوا هوﺮﮔ ﻦﯿﺑ ﺰﻣﺮﻗ يﺎﻫ لﻮﺒﻠﮔ ناﺰﯿﻣ رد ،راد ﯽﻨﻌﻣ توﺎﻔﺗ زا ﯽﮐﺎﺣ ﻦﯾا ﻪﮐ ،دﻮﺑ ﺎﻫ هوﺮﮔ ﺮﯾﺎﺳ و لوا هوﺮﮔ ﻦﯿﺑ يراد ﯽﻨﻌﻣ توﺎﻔﺗ ﻦﯿﺑﻮﻠﮔﻮﻤﻫ ﺎﺑ ﻪﻄﺑار رد .ﺪﺸﻧ هﺪﻫﺎﺸﻣ يراد ﯽﻨﻌﻣ ﯽﻨﻌﻣ توﺎﻔﺗ ﻦﯿﻨﭽﻤﻫ .ﺪﺸﻧ هﺪﻫﺎﺸﻣ مﻮﺳ و مود هوﺮﮔ ﻦﯿﺑ توﺎﻔﺗ ﻪﻄﺑار رد ﻪﻌﻟﺎﻄﻣ درﻮﻣ يﺎﻫ هوﺮﮔ مﺎﻤﺗ ﻦﯿﺑ يراد
ياﺮﺑ هﺎﻣ ﻪﺳ زا ﺮﺘﺸﯿﺑ ﯽﺗﺪﻣ و ،ﺖﺳا راﺬﮔ ﺮﺛا ﯽﻧﻮﺧ ﻞﻣاﻮﻋ ﺮﺑ ﺎﻫﺪﯿﺋوﺮﺘﺳا فﺮﺼﻣ .ﺪﯾدﺮﮔ هﺪﻫﺎﺸﻣ ﺖﯾﺮﮐﻮﺗﺎﻤﻫ ﺎﺑ .ﺖﺳا زﺎﯿﻧ ﻪﯿﻟوا ﺖﻟﺎﺣ ﻪﺑ ﻞﻣاﻮﻋ ﻦﯾا ﺖﺸﮔزﺎﺑ
ماﺪﻧا شروﺮﭘ ،ﮏﯾژﻮﻟﻮﺗﺎﻤﻫ ،ﺪﯿﺋوﺮﺘﺳا :يﺪﯿﻠﮐ نﺎﮔژاو
Abstract
The aim of the present research is to study the effects of steroids abuse over blood factors in athletes of bodybuilding field. the present investigation is post event and involves 48 sportsmen in the field of bodybuilding (age 25.02 ± 4.73 years old)They are divided into three groups involving sportsmen consuming steroid (n1 = 16), sportsmen having a record and three months out of consumption (n2 = 16), and sportsmen having no record of consuming steroid (n3 = 16). After measuring anthropometric and 1RM, blood samples were taken 12 hours before breakfast. The results showed that there were significant differences between the first and third groups at the rate of red blood cells but between the second and third groups significant differences were not observed. In relationship with hemoglobin there were significant differences between the first group and the other groups, but this difference wasn’t observed between the second and third groups. There were also significant differences between all case study groups in relationship with hematocrit. Using steroids effects on
blood factors and it takes more than three months for these factors to their primary state.
Keywords: Steroid, Hematologic, Body building
ﻪﻣﺪﻘﻣ
دﻮﺟﻮﻣ ﺪﻫاﻮﺷ .دراد ﺖﻣﺪﻗ ﯽﺘﺑﺎﻗر يﺎﻫ شزرو ﺮﻤﻋ هزاﺪﻧا ﻪﺑ ،ﯽﯾآرﺎﮐ ﺶﯾاﺰﻓا ﺖﻬﺟ ازوﺮﯿﻧ داﻮﻣ فﺮﺼﻣ ًاﺮﻫﺎﻇ دﻮﺷ ﯽﻣ مﺎﺠﻧا هدﺮﺘﺴﮔ رﻮﻄﺑ يا ﻪﻓﺮﺣ شزرو رد ازوﺮﯿﻧ يﺎﻫوراد لﺎﻤﻌﺘﺳا هزوﺮﻣا ﻪﮐ ﺪﻨﻫد ﯽﻣ نﺎﺸﻧ )
ﺐﻠﺣ
،ﯽﭼ (1386 ﯽﻣ ﺢﺷﺮﺗ ﺎﻫ ﻪﻀﯿﺑ رد ﻊﻗاو ﯽﺴﻨﺟ يﺎﻫ هﺪﻏ زا نادﺮﻣ رد ﻪﮐ ﺖﺳا يﺪﯿﺋوﺮﺘﺳا نﻮﻣرﻮﻫ ،نوﺮﺘﺳﻮﺘﺴﺗ .
.ددﺮﮔ ﯽﻣAAS
ﯽﻣ دﺎﯾ داﻮﻣ ﻦﯾا ﯽﻧژورﺪﻧآ صاﻮﺧ ناﻮﻨﻋ ﻪﺑ نآ زا ﻪﮐ دﻮﺷ ﻪﻧادﺮﻣ تﺎﻔﺻ زوﺮﺑ ﺐﺟﻮﻣ ﺪﻧاﻮﺗ
ددﺮﮔ ) ،نووﺮﺑ (2005
ﮏﯿﻟﻮﺑﺎﻧآ يﺎﻫﺪﯿﺋوﺮﺘﺳا هوﻼﻋ ﻪﺑ . -
ﮏﯿﻧژورﺪﻧآ )3
اﺰﻓا ﺐﺟﻮﻣ (AAS
،ﯽﻧﻼﻀﻋ هدﻮﺗ ﺶﯾ
ﺪﻨﻧاد ﯽﻣ ﺎﻬﻧآ ﯽﮑﯿﻟﻮﺑﺎﻧآ صاﻮﺧ ءﺰﺟ ار دراﻮﻣ ﻦﯾا ﻪﮐ دﻮﺷ ﯽﻣ ﺎﻫ ناﻮﺨﺘﺳا ﯽﻟﺎﮕﭼ ﺶﯾاﺰﻓا و نﺪﺑ ﯽﺑﺮﭼ ﺶﻫﺎﮐ ) ،لﺎﻫ (2005 فﺮﺼﻣ ﺐﻗﺎﻌﺘﻣ ﺰﯿﻧ ﯽﻧﻮﺧ ﻞﻣاﻮﻋ تاﺮﯿﯿﻐﺗ . ﻦﯾا نﺎﮔ هﺪﻨﻨﮐ هدﺎﻔﺘﺳا نﺎﯿﻣ رد AAS
دﻮﻬﺸﻣ داﻮﻣ
لﻮﺒﻠﮔ ﻂﺳﻮﺘﻣ ﺶﯾاﺰﻓا اﺮﯾز ﺖﺳا ﻪﺟﻮﺗ ﻞﺑﺎﻗ ﺎﻣا ﺪﺷﺎﺑ ﯽﻣ ﻒﯿﻔﺧ درﻮﻣ ﻦﯾا رد ﯽﻧﻮﺧ ﻞﻣاﻮﻋ ﺶﯾاﺰﻓا ﻪﮑﻨﯾا ﺎﺑ .ﺖﺳا ﺰﻣﺮﻗ يﺎﻫ ﻦﯿﺑﻮﻠﮔﻮﻤﻫ ،4
ﺖﯾﺮﮐﻮﺗﺎﻤﻫ ،5
هﺪﻨﻨﮐ فﺮﺼﻣ نادﺮﻣ رد نﻮﺧ ﺪﯿﻔﺳ يﺎﻫ لﻮﺒﻠﮔ و 6
زا ﯽﺧﺮﺑ ردAAS
ﺖﺳا هﺪﺷ شراﺰﮔ ﻂﺒﺗﺮﻣ تﺎﻌﻟﺎﻄﻣ )
،نارﺎﮑﻤﻫ و ﺖﻧوﺎﺳﺎﮐ (2007
ﻂﺳﻮﺗ ﻪﮐ ﯽﺸﻫوﮋﭘ ﻪﺑ ناﻮﺗ ﯽﻣ ﻪﻨﯿﻣز ﻦﯾا رد .
) نارﺎﮑﻤﻫ و رﻮﯿﺋﺎﻣ ﯽﻧﻮﺧ ﻞﻣاﻮﻋ نآ رد ﻪﮐ ،دﻮﻤﻧ هرﺎﺷا ﺪﺷ مﺎﺠﻧا (2011
هوﺮﮔ ود ﺐﻟﺎﻗ رد زﺎﺴﻧﺪﺑ دﺮﻣ22
ﻣ هوﺮﮔ ﻦﯿﺑ راد ﯽﻨﻌﻣ توﺎﻔﺗ ﺮﮕﻧﺎﺸﻧ ﺶﻫوﮋﭘ ﻦﯾا يﺎﻫ ﻪﺘﻓﺎﯾ .ﺖﻓﺮﮔ راﺮﻗ ﯽﺳرﺮﺑ درﻮﻣ هﺪﻨﻨﮐ فﺮﺼ
هوﺮﮔ وAAS
هﺪﻨﻨﮐ فﺮﺼﻣ ﺮﯿﻏ دﻮﺑ ﺰﻣﺮﻗ يﺎﻫ لﻮﺒﻠﮔ و ﺖﯾﺮﮐﻮﺗﺎﻤﻫ ،ﻦﯿﺑﻮﻠﮔﻮﻤﻫ ناﺰﯿﻣ ﺎﺑ ﻪﻄﺑار ردAAS
) ،نارﺎﮑﻤﻫ و رﻮﯿﺋﺎﻣ
(2011 فﺮﺼﻣ نﺎﻤﺘﮐ رد ﯽﻌﺳ هراﻮﻤﻫ نارﺎﮑﺷزرو ﻪﮐ ﺎﺠﻧآ زا . رد ﻖﯿﻗد تﺎﻋﻼﻃا ﺐﺴﮐ ،ﺪﻨﯾﺎﻤﻧ ﯽﻣAAS
فﺮﺼﻣ عﻮﯿﺷ ﺎﺑ ﻪﻄﺑار ﺖﺳا يراﻮﺷد رﺎﮐAAS
) ،ﯽﭼ ﺐﻠﺣ (1386
رﺎﺛآ ﯽﺳرﺮﺑ ﻪﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد ،ور ﻦﯾا زا .
ﻞﻣاﻮﻋ ﺮﺑAAS
.دﻮﺷ ﯽﻣ ﻪﺘﺧادﺮﭘ ﯽﻧﻮﺧ
ﻖﯿﻘﺤﺗ ﯽﺳﺎﻨﺷ شور
زا ﻞﮑﺸﺘﻣ يرﺎﻣآ ﻪﻧﻮﻤﻧ و ،ﺖﺳا يداﺪﯾور ﺲﭘ عﻮﻧ زا ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ماﺪﻧا شروﺮﭘ ﻪﺘﺷر رﺎﮑﺷزرو دﺮﻣ ﺮﻔﻧ48
ﻦﺳ) /73 4
± /02 ﺪﻗ ،لﺎﺳ25 /76
6
± /37 نزو ،ﺮﺘﻣ ﯽﺘﻧﺎﺳ175
/33 6
± /75 نﺎﺘﺳﺮﻬﺷ رد (مﺮﮔﻮﻠﯿﮐ80
ﺪﺷﺎﺑ ﯽﻣ دﺎﺑآﺪﺳا هوﺮﮔ ﻪﺳ ﺐﻟﺎﻗ رد ﺎﻫ ﯽﻧدﻮﻣزآ .
هﺪﻨﻨﮐ فﺮﺼﻣ نارﺎﮑﺷزرو ،لوا هوﺮﮔ ﻞﻣﺎﺷ ﻪﮐ هﺮﻔﻧ16
AAS
فﺮﺼﻣ ﻪﻘﺑﺎﺳ ﺎﺑ نارﺎﮑﺷزرو ،مود هوﺮﮔ ، دﻮﺑ ﯽﻧارﺎﮑﺷزرو ﻞﻣﺎﺷ مﻮﺳ هوﺮﮔ و ،فﺮﺼﻣ زا يرود هﺎﻣ ﻪﺳ وAAS
فﺮﺼﻣ ﻪﻘﺑﺎﺳ ﻪﮐ ﺳرﺪﻨﺗ هﮋﯾو ﻪﻣﺎﻧ ﺶﺳﺮﭘ زا ﺎﻫ ﯽﻧدﻮﻣزآ ﺖﻣﻼﺳ ﯽﺑﺎﯾزرا ﺖﻬﺟ .ﺪﻨﺘﺷاﺪﻧ ارAAS
7ﯽﺘ ﺪﺷ هدﺎﻔﺘﺳا
ﺮﮑﯿﭘ يﺎﻫ نﻮﻣزآ مﺎﺠﻧا و ﯽﻧﻼﻀﻋ ﻂﯿﺤﻣ ،ترﺪﻗ دروآﺮﺑ .ﺪﯾدﺮﮔ ﺬﺧا نﺎﺒﻠﻃواد مﺎﻤﺗ زا ﯽﺒﺘﮐ ﻪﻣﺎﻧ ﺖﯾﺎﺿر و
8ﯽﺠﻨﺳ ﺪﻣآ ﻞﻤﻋ ﻪﺑ يﺮﯿﮕﻧﻮﺧ زا ﻞﺒﻗ زور ﺪﻨﭼ ﺰﯿﻧ زا ﺲﭘ ﺎﻫ ﯽﻧدﻮﻣزآ ﺖﯾﺎﻬﻧ رد .
ﻦﯾﺮﻤﺗ زا ﺰﯿﻫﺮﭘ ﺖﻋﺎﺳ48
و ﺪﯾﺪﺷ ﺖﻋﺎﺳ ،ﯽﯾﺎﺘﺷﺎﻧ ﺖﻋﺎﺳ12
راو ،هﺪﺷ ﻦﯿﯿﻌﺗ زور ﺢﺒﺻ8 ﺖﻟﺎﺣ رد ﯽﻧدﻮﻣزآ ﺮﻫ زا و ﺪﻧﺪﺷ هﺎﮕﺸﯾﺎﻣزآ د
3 -Anabolic-Androgenic Steroids (AAS)
4 -Red Blood Cells (RBC)
5 -Hemoglobin (Hb)
6 -Hematocrit (HCT)
7 - PAR- Q and you
8 - Anthropometric
.ﺪﺷ ﻪﺘﻓﺮﮔ هﺎﮕﺸﯾﺎﻣزآ سﺎﻨﺷرﺎﮐ ﻂﺳﻮﺗ ﺎﻬﻧآ لﺎﺘﯿﺑﻮﮐ ﺪﯾرو زا نﻮﺧ ﯽﺳ ﯽﺳ ﺞﻨﭘ ناﺰﯿﻣ ﻪﺑ ﻪﺘﺴﺸﻧ ناﺰﯿﻣ ﻦﯿﻨﭽﻤﻫ
هﺎﮕﺘﺳد ﻂﺳﻮﺗ ﺰﯿﻧ ﯽﻧﻮﺧ ﻞﻣاﻮﻋ
cell counter (Sysmex Kx 21 N)
ﻦﯿﺑ ﺞﯾﺎﺘﻧ ﻪﺴﯾﺎﻘﻣ .ﺪﯾدﺮﮔ ﺺﺨﺸﻣ
راﺰﻓا مﺮﻧ ﻂﺳﻮﺗ ،ﯽﻫوﺮﮔ
SPSS.22
و ﻪﻓﺮﻃ ﮏﯾ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ نﻮﻣزآ زا هدﺎﻔﺘﺳا ﺎﺑ ﯽﮐﻮﺗ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ و9
10
ﺢﻄﺳ رد /05
0
<
.ﺖﻓﺮﯾﺬﭘ ترﻮﺻp
ﺎﻫ ﻪﺘﻓﺎﯾ
لوﺪﺟ ﻖﺑﺎﻄﻣ ناﺰﯿﻣ رد ،راد ﯽﻨﻌﻣ توﺎﻔﺗ زا ﯽﮐﺎﺣ ﺞﯾﺎﺘﻧ ،1
،دﻮﺑ مﻮﺳ هوﺮﮔ و لوا هوﺮﮔ ﻦﯿﺑ ﺰﻣﺮﻗ يﺎﻫ لﻮﺒﻠﮔ
ﻪﺳ ﺮﻫ ﻦﯿﺑ ﺖﯾﺮﮐﻮﺗﺎﻤﻫ ناﺰﯿﻣ ﺎﺑ ﻪﻄﺑار رد .دﻮﺒﻧ دﻮﻬﺸﻣ ﻦﯿﺑﻮﻠﮔﻮﻤﻫ درﻮﻣ رد مﻮﺳ و مود هوﺮﮔ ﻦﯿﺑ توﺎﻔﺗ ﻦﯾا ﻪﮐ .ﺪﺷ هﺪﻫﺎﺸﻣ يراد ﯽﻨﻌﻣ توﺎﻔﺗ ﻪﻌﻟﺎﻄﻣ درﻮﻣ هوﺮﮔ
لوﺪﺟ ﻖﯿﻘﺤﺗ ﻪﻧﺎﮔ ﻪﺳ يﺎﻫ هوﺮﮔ ﮏﯿﮑﻔﺗ ﻪﺑ ﯽﻧﻮﺧ ﻞﻣاﻮﻋ ناﺰﯿﻣ :1
هوﺮﮔ
ﺮﯿﯿﻐﺘﻣ
يراد ﯽﻨﻌﻣ
لوا هوﺮﮔ
مود هوﺮﮔ
مﻮﺳ هوﺮﮔ
RBC (m/100ml) β
/32 0
± /8 5 /3
0
± /56 5 /15
0
± /49 5
Hb (g/100ml)
* β /69
0
± /57 17 /26
0
± /15 16 /96
0
± /56 15
HCT (%)
* βα /39
2
± /56 53 /89
0
± /3 47 /95
1
± /63 44
،مود و لوا هوﺮﮔ ﻦﯿﺑ يراد ﯽﻨﻌﻣ * ،مﻮﺳ و لوا هوﺮﮔ ﻦﯿﺑ يراد ﯽﻨﻌﻣβ
مﻮﺳ و مود هوﺮﮔ ﻦﯿﺑ يراد ﯽﻨﻌﻣα
يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
ﻞﻤﺣ ﺖﯿﻓﺮﻇ و ﻦﯿﺑﻮﻠﮔﻮﻤﻫ ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ نآ ﺐﻗﺎﻌﺘﻣ ﻪﮐ دﻮﺷ ﻦﯿﺘﯾﻮﭘوﺮﺘﯾرا ﺰﺘﻨﺳ ﺶﯾاﺰﻓا ﺚﻋﺎﺑ ﺪﻧاﻮﺗ ﯽﻣAAS
ﺪﻫد خر ﺰﻣﺮﻗ يﺎﻫ لﻮﺒﻠﮔ ﺶﯾاﺰﻓا ﻪﺠﯿﺘﻧ رد ﺖﺳا ﻦﮑﻤﻣ ،نژورﺪﻧآ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ ﺮﺛا ﻦﯾا ﻪﮐ ددﺮﮔ ﯽﻣ نﮋﯿﺴﮐا ) (.2 ﻪﺑ راداو ار ﺖﻓﺎﺑ ﻦﯾا ﺪﻧاﻮﺗ ﯽﻣ ناﻮﺨﺘﺳا ﺰﻐﻣ زﺎﺳ نﻮﺧ يدﺎﯿﻨﺑ يﺎﻫ لﻮﻠﺳ ﻢﯿﻘﺘﺴﻣ ﮏﯾﺮﺤﺗ ﺎﺑ نوﺮﺘﺳﻮﺘﺴﺗ ﻪﺑ يزﺎﺳ نﻮﺧ ﺪﻨﯾاﺮﻓ ﺮﺑ نوﺮﺘﺳﻮﺘﺴﺗ رﺎﺛآ رد ﯽﻟﻮﮑﻟﻮﻣ يﺎﻫ ﻢﺴﯿﻧﺎﮑﻣ ﺖﺧﺎﻨﺷ ياﺮﺑ ﻪﺘﺒﻟا ،ﺪﯾﺎﻤﻧ يزﺎﺴﻧﻮﺧ
ﺖﺳا زﺎﯿﻧ يﺮﺘﺸﯿﺑ تﺎﻘﯿﻘﺤﺗ )
،يﻮﺳﻮﻣو ﻞﺳﺎﯿﺸﺧر ،يﺰﯾﺮﺒﺗزﺎﺳاود (2012
فﺮﺼﻣ هوﺮﮔ ﻦﯿﺑ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ رد .
هﺪﻨﻨﮐ يراد ﯽﻨﻌﻣ توﺎﻔﺗ ﺖﯾﺮﮐﻮﺗﺎﻤﻫ و ﻦﯿﺑﻮﻠﮔﻮﻤﻫ ،ﺰﻣﺮﻗ يﺎﻫ لﻮﺒﻠﮔ ناﺰﯿﻣ ﺎﺑ ﻪﻄﺑار رد ﺎﻫ هوﺮﮔ ﺮﯾﺎﺳ وAAS
) نارﺎﮑﻤﻫ و رﻮﯿﺋﺎﻣ ﻖﯿﻘﺤﺗ ﺎﺑ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ،ﻪﻨﯿﻣز ﻦﯾا رد ﻪﮐ ،ﺪﺷ هﺪﻫﺎﺸﻣ ﺪﺷﺎﺑ ﯽﻣ ﻮﺴﻤﻫ (2011
) و رﻮﯿﺋﺎﻣ
،نارﺎﮑﻤﻫ (2011
.
ﻣءﻮﺳ ﻪﮐ دﻮﻤﻧ طﺎﺒﻨﺘﺳا ﻦﯿﻨﭼ ناﻮﺗ ﯽﻣ ،ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ يﺎﻫ ﻪﺘﻓﺎﯾ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻞﻣاﻮﻋ ﺮﺑ يﺪﯿﺋوﺮﺘﺳا يﺎﻫوراد فﺮﺼ
ﻦﯾا فﺮﺼﻣ كﺮﺗ زا هﺎﻣ ﻪﺳ ﺖﺷﺬﮔ زا ﺲﭘ ﻪﮐ ﺖﺳا راﺬﮔ ﺮﺛا يﻮﺤﻧ ﻪﺑ ماﺪﻧا شروﺮﭘ ﻪﺘﺷر نارﺎﮑﺷزرو ﯽﻧﻮﺧ فﺮﺼﻣ زا ﯽﺷﺎﻧ ﯽﻧﻮﺧ ضراﻮﻋ ،يﻮﻗ لﺎﻤﺘﺣا ﻪﺑ دراﻮﻣ ﻦﯾا مﺎﻤﺗ ﺎﺑ و ﺪﺷﺎﺑ ﯽﻣ دﻮﻬﺸﻣ نﺎﻨﭽﻤﻫ نآ ضراﻮﻋ ،داﻮﻣ
9 -One-Way-ANOVA
10 -Tukey
ﯿﻟوا ﺖﻟﺎﺣ ﻪﺑ داﻮﻣ ﻦﯾا فﺮﺼﻣ كﺮﺗ زا ﺲﭘAAS
زا ﺮﺘﺸﯿﺑ ﯽﻧﺎﻣز تﺪﻣ فﺮﺻ ﺪﻨﻣزﺎﯿﻧ ﺎﻣا ،ﺪﻨﺘﺴﻫ ﺮﯾﺬﭘ ﺖﺸﮔزﺎﺑ ﻪ
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