ﺮﯿﺛﺎﺗ ﻦﯿﻠﭘا ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ ﺮﺑ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12
- تر ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا ،13 ﺮﻧ يﺎﻫ
قﺎﭼ
ﻦﯿﺠﺸﻫ ﯽﻤﺘﺳر اﺮﻫز ﯽﻨﯿﺋﺎﮔ ﯽﻠﻌﺳﺎﺒﻋ ﺮﺘﮐد ،1
ﻪﻨﯿﺑﻮﭼ سوﺮﯿﺳ ﺮﺘﮐد ،2
حور ﺮﺘﮐد ،3
ﻖﺣ ﷲا -
سﺎﻨﺷ
4
-1 ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هﺪﮑﺸﻧاد ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ ناﺮﻬﺗ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ و
-2 ناﺮﻬﺗ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هﺪﮑﺸﻧاد ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ دﺎﺘﺳا
-3 ناﺮﻬﺗ هﺎﮕﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هﺪﮑﺸﻧاد ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ رﺎﯾدﺎﺘﺳا
-4 ،ﯽﻧﺎﺴﻧا مﻮﻠﻋ و تﺎﯿﺑدا هﺪﮑﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هوﺮﮔ رﺎﯾدﺎﺘﺳا نﺎﻨﻤﺳ هﺎﮕﺸﻧاد
هﺪﯿﮑﭼ
هﺪﺷ ﻒﺸﮐ هزﺎﺗ ﻦﯾﺎﮐﻮﭙﯾدآ ﻦﯿﻠﭘا :ﻪﻣﺪﻘﻣ ﯽﻣ ﺶﯾاﺰﻓا ﻦﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ و ﯽﻗﺎﭼ ﻪﺑ نﺎﯾﻼﺘﺒﻣ رد ﻪﮐ ﺖﺳا يا
ﻪﺑ .ﺪﺑﺎﯾ
ﯽﺳرﺮﺑ ،ﺮﺿﺎﺣ ﺶﻫوﮋﭘ فﺪﻫ .دراد ﯽﯾﺎﻤﺳﻼﭘ ﻦﯿﻠﭘا ﺮﯾدﺎﻘﻣ ﺮﺑ يﺮﯿﺛﺎﺗ ﻪﭼ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﺖﺴﯿﻧ مﻮﻠﻌﻣ ﯽﻨﺷور ﺮﯿﺛﺎﺗ ا ناﺰﯿﻣ ﺮﺑ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12 ﻦﯿﻠﭘ
- تر ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا ،13 شور .دﻮﺑ قﺎﭼ ﺮﻧ يﺎﻫ
:ﯽﺳﺎﻨﺷ ﺮﺳ14
ﺖﺳد بﺮﭼﺮﭘ سﺮﺘﺳدرد ﯽﯾاﺬﻏ ﻢﯾژر ﺖﺤﺗ ﻪﺘﻔﻫ ﺖﺸﻫ تﺪﻣ ﻪﺑ تر ﯽﻟ ﺺﺧﺎﺷ ﻪﺑ ﻪﺟﻮﺗﺎﺑ و ﺪﻨﺘﻓﺮﮔ راﺮﻗ زﺎﺳ
نآ ﯽﻗﺎﭼ ﻢﯾژر هوﺮﮔ ود ﺮﻫ ﻪﻠﺣﺮﻣ ﻦﯾا رد .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ ﻦﯾﺮﻤﺗ و لﺮﺘﻨﮐ هوﺮﮔ ود ﻪﺑ ،ﯽﻗﺎﭼ زا ﺲﭘ .ﺪﺷ مﻮﻠﻌﻣ ﺎﻫ
ﺘﺳا ﯽﯾاﺬﻏ تﺪﻣ ﻪﺑ ﻦﯾﺮﻤﺗ هوﺮﮔ .ﺪﻨﺘﺷاد دراﺪﻧﺎ
ﻪﺴﻠﺟ ﺮﻫ) ﻪﺘﻔﻫ12 ﺖﻋﺮﺳ زا ﻪﻘﯿﻗد60
ﺎﺗ25 و ﻪﻘﯿﻗد رد ﺮﺘﻣ30
ﻦﯿﻠﭘا ﯽﻫﺎﮕﺸﯾﺎﻣزآ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ياﺮﺑ اﺰﯾﻻا شور .ﺪﻧﺪﯾود ﺐﯿﺷ نوﺪﺑ ﻞﯿﻣدﺮﺗ يور (ﻪﺘﻔﻫ رد زور5 -
و13
نﻮﻣزآ .ﺪﺷ هدﺎﻔﺘﺳا ﺰﮐﻮﻠﮔ ﻪﺒﺳﺎﺤﻣ ياﺮﺑ يﺮﺘﻣﻮﺘﻓ شور و ﻦﯿﻟﻮﺴﻧا ﻘﻣ ياﺮﺑ ﻞﻘﺘﺴﻣ t
هدﺎﻔﺘﺳا ﺎﻫﺮﯿﻐﺘﻣ ﻦﯿﮕﻧﺎﯿﻣ ﻪﺴﯾﺎ
يرادﺎﻨﻌﻣ ﺢﻄﺳ و ﺪﺷ /05
.دﻮﺑ0
ﻪﺘﻓﺎﯾ نﻮﻣزآ ﺞﯾﺎﺘﻧ :ﺎﻫ تر ﻦﯿﻠﭘا و ﻦﯿﻟﻮﺴﻧا ،ﺰﮐﻮﻠﮔ ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ،داد نﺎﺸﻧ ﻞﻘﺘﺴﻣ t
هوﺮﮔ قﺎﭼ ﺮﻧ يﺎﻫ
ﺎﻨﻌﻣ توﺎﻔﺗ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ و لﺮﺘﻨﮐ )ﺖﺷاد دﻮﺟو يراد
/05 0
<
هوﺮﮔ رد ﻦﯿﻟﻮﺴﻧا و ﺰﮐﻮﻠﮔ ﺮﯾدﺎﻘﻣ ،ﻦﯿﻨﭽﻤﻫ .(P
ﻦﯿﻠﭘا ﺮﯾدﺎﻘﻣ و دﻮﺑ لﺮﺘﻨﮐ هوﺮﮔ زا ﺮﺘﻤﮐ ﻦﯾﺮﻤﺗ -
ﯽﮕﺘﺴﺒﻤﻫ نﻮﻣزآ .دﻮﺑ لﺮﺘﻨﮐ هوﺮﮔ زا ﺮﺘﺸﯿﺑ ﻦﯾﺮﻤﺗ هوﺮﮔ رد13
ﻦﯿﻠﭘا ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ ﻦﯿﺑ نﻮﺳﺮﯿﭘ -
)ﻦﯿﻟﻮﺴﻧا و13 /07
=0 ﻦﯿﻠﭘا ،(P
- )ﺰﮐﻮﻠﮔ و13 /055
=0 زا ﺲﭘ (P
ﻪﺘﻔﻫ12
ﺎﻨﻌﻣ ﻪﻄﺑار ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ .داﺪﻧ نﺎﺸﻧ ار يراد
ﻦﯾﺮﻤﺗ :يﺮﯿﮔ ﻪﺠﯿﺘﻧ ﯽﻣ ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا
نﺎﻣرد ردﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا ،ﻦﯿﻠﭘا ﺮﯾدﺎﻘﻣ تاﺮﯿﯿﻐﺗ و نزو لﺮﺘﻨﮐ ﺎﺑ ﺪﻧاﻮﺗ
ﺶﯿﭘ و ﯽﻗﺎﭼ .ﺪﺷﺎﺑ ﺮﺛﻮﻣ ﯽﻗﺎﭼ ﻪﺑ ﻪﺘﺴﺑاو ﺖﺑﺎﯾد زا يﺮﯿﮔ
هژاو ﻦﯿﻠﭘا ،ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ،ﯽﻗﺎﭼ :يﺪﯿﻠﮐ يﺎﻫ -
ﺰﮐﻮﻠﮔ ،ﻦﯿﻟﻮﺴﻧا ،13
Abstract
Introduction: Apelin is a newly discovered adipokine which increases in obese and insulin resistant people. It’s not clear, endurance exercise training, cause changes in plasma levels of apelin. The aim of this study was to determine the effect of 12 weeks endurance training on plasma levels of apelin-13, insulin and glucose in obese male rats.
ﯽﺷزرو ﻪﯾﺬﻐﺗ و يژﻮﻟﻮﯾﺰﯿﻓ
Methods: 14 obese male Wistar rats were fed for 8 weeks with a free access and handmade high fat diet, and based on Lee Index, became obese. After the match, the rats were randomly divided into control group(n=7) and training group(n=7)(60 minutes per session, 15 to 30 meters per minute, 5 days per week for 12 weeks) Running on a treadmill with no incline. The ELISA method was used for laboratory analysis of Apelin-13 and insulin and photometric glucometer used for analysis of glucose. T test was used to comparing of variables mean, and significant level was 0.05.
Results: The results of independent T test showed that, there was significant difference in plasma levels of glucose, insulin and apelin between control and exercise groups in obese male rats(P<0.05). Also glucose, and insulin levels of exercise group were lower than control group and apelin-13 levels of exercise group were higher than control group. Pearson’s correlation test showed, there wasn't a significant relationship between levels of apelin-13 and insulin(P=0.07), apelin-13 and glucose(P=0.055), after 12 weeks endurance training.
Conclusion: High intensity endurance training through weight control and changes in apelin, insulin and glucose levels can be effective in obesity treatment and prevention of obesity related diabetes.
Key words: Obesity, Endurance training, Apelin-13, Insulin, Glucose
ﻪﻣﺪﻘﻣ
رﺎﺑ ﻦﯿﻟوا ﻦﯿﻠﭘا ﺪﯿﺘﭙﭘ زا
هرﺎﺼﻋ هﺪﻌﻣ وﺎﮔ ﻪﺑ ناﻮﻨﻋ ﺪﻧﺎﮕﯿﻟ نورد داز هﮋﯾو هﺪﻧﺮﯿﮔ
1 APJ
جاﺮﺨﺘﺳا )ﺪﺷ
ﻪﻌﻟﺎﻄﻣ .(1
ﺖﯿﺳﻮﭙﯾدآ ﯽﻣ نﺎﺸﻧ شﻮﻣ و نﺎﺴﻧا يﺎﻫ
لﻮﻠﺳ زا ﻦﯿﻠﭘا ،ﺪﻫد ﯽﻣ دازآ ﯽﺑﺮﭼ يﺎﻫ
ﻪﺑ ﻦﯿﻟﻮﺴﻧا ﺎﺑ ﺎﻤﯿﻘﺘﺴﻣ و دﻮﺷ رﻮﻃ
ﯽﻣ ﻢﯿﻈﻨﺗ ﯽﺸﯾاﺰﻓا )دﻮﺷ
(1 . ﻦﯿﻠﭘا ﺮﯾدﺎﻘﻣ ﺮﺑ ﯽﺷزرو ﻦﯾﺮﻤﺗ ﺮﯿﺛﺎﺗ هرﺎﺑرد و
ﺶﻃﺎﺒﺗرا ﺎﺑ
ﯽﻗﺎﭼ و ﺖﻣوﺎﻘﻣ ﻦﯿﻟﻮﺴﻧا
ﯽﻣ ﺎﻬﻨﺗ .ﺖﺳا سﺮﺘﺳدرد ﯽﻤﮐ تﺎﻌﻟﺎﻄﻣ ﻪﺑ ناﻮﺗ
ﺖﯿﻟﺎﻌﻓ و ﯽﮔﺪﻧز ﮏﺒﺳ ﻪﻠﺧاﺪﻣ ﺮﯿﺛﺎﺗ ﻪﮐ دﺮﮐ هرﺎﺷا ﯽﺗﺎﻌﻟﺎﻄﻣ
ار ﯽﻧﺪﺑ قﺎﭼﺮﯿﻏ و دﺎﯾز لوﺮﺘﺴﻠﮐ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد هدﺮﮐ ﯽﺳرﺮﺑ ﯽﺘﺑﺎﯾد نارﺎﻤﯿﺑ و
)ﺪﻧا و2 .(3
ﻦﯾا ﻪﺑ ﻪﺟﻮﺗﺎﺑ ﯽﺗﻻﻼﺘﺧا ﻪﮐ
ﻞﺜﻣ ﯽﻤﻨﯿﻟﻮﺴﻧاﺮﭙﯾﺎﻫ و
ﺖﺑﺎﯾد عﻮﻧ زا 2 تﻻﻼﺘﺧا ﻪﺘﺴﺑاو
ﻪﺑ ﯽﻗﺎﭼ ﺖﺳا و ﻦﯾﺮﻤﺗ
ﻢﻈﻨﻣ ﯽﺷزرو ﻋﺎﺑ
ﺚ ﺶﻫﺎﮐ ﺮﯾدﺎﻘﻣ ﯽﯾﺎﻤﺳﻼﭘ ﻦﯿﻟﻮﺴﻧا
و ﺰﮐﻮﻠﮔ و دﻮﺒﻬﺑ
ﺖﯿﺳﺎﺴﺣ ﻦﯿﻟﻮﺴﻧا
ﯽﻣ دﻮﺷ نآ زا و ﻪﮐ ﺎﺟ
ﻦﯿﻠﭘا ﻪﮐ ﺖﺳا ﯽﻨﯾﺎﮐﻮﭙﯾدآ ﺎﺑ
و ﻦﯿﻟﻮﺴﻧا نزو
طﺎﺒﺗرا دراد ﻦﯾا لاﻮﺳ حﺮﻄﻣ ﯽﻣ دﻮﺷ ﻪﮐ ﻦﯾﺮﻤﺗ ﯽﺷزرو ﻪﭼ يﺮﯿﺛﺎﺗ
ﺮﺑ ناﺰﯿﻣ
،ﻦﯿﻠﭘا
؟دراد ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا اﺬﻟ
فﺪﻫ زا ﺶﻫوﮋﭘ
،ﺮﺿﺎﺣ ﯽﺳرﺮﺑ ﺮﯿﺛﺎﺗ ﻪﺘﻔﻫ12
ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﺮﺑ
ﺮﯾدﺎﻘﻣ ﯽﯾﺎﻤﺳﻼﭘ ﻦﯿﻠﭘا
-
، 13 ﺰﮐﻮﻠﮔ و ﻦﯿﻟﻮﺴﻧا رد
تر يﺎﻫ ﺮﻧ قﺎﭼ ﺖﺳا .
شور ﯽﺳﺎﻨﺷ
تﺪﻣ ﻪﺑ ﯽﻫﺎﮕﺸﯾﺎﻣزآ تﺎﻧاﻮﯿﺣ زا ﺖﯾﺎﻤﺣ نﺎﯿﻧاﺮﯾا ﻦﻤﺠﻧا ﯽﺸﻣ ﻂﺧ ﻖﺑﺎﻄﻣ رﺎﺘﺴﯾو ﺮﻧ تر ﺮﺳ14 ﺖﺤﺗ ﻪﺘﻔﻫ8
رد ﯽﯾاﺬﻏ ﻢﯾژر ﺖﺳد بﺮﭼﺮﭘ سﺮﺘﺳد
ﺎﺑ و ﺪﻨﺘﻓﺮﮔ راﺮﻗ زﺎﺳ ﺺﺧﺎﺷ ﻪﺑ ﻪﺟﻮﺗ
2ﯽﻟ زا ﺲﭘ .ﺪﻧﺪﺷ بﻮﺴﺤﻣ قﺎﭼ
تر ،نﺪﺷ قﺎﭼ .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ ﻦﯾﺮﻤﺗ و لﺮﺘﻨﮐ هوﺮﮔ ود ﻪﺑ ﺎﻫ
تر ﻦﯾﺮﻤﺗ هوﺮﮔ يﺎﻫ تﺪﻣ ﻪﺑ ﻪﺘﻔﻫ رد زور5
12
.ﺪﻧﺪﯾود ﺐﯿﺷ نوﺪﺑ ﻞﯿﻣدﺮﺗ يور (دراﺪﻧﺎﺘﺳا ياﺬﻏ فﺮﺼﻣ ﺎﺑ) ﻪﺘﻔﻫ
لوﺪﺟ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﻣﺎﻧﺮﺑ .1
ﻪﺘﻔﻫ لوا ﻪﺘﻔﻫ
مود ﻪﺘﻔﻫ
مﻮﺳ ﻪﺘﻔﻫ مرﺎﻬﭼ ...
ﻪﺘﻔﻫ ﻢﺸﺷ ...
ﻪﺘﻔﻫ ﻢﺘﺸﻫ ...
ﻪﺘﻔﻫ ﻢﻫدزاود
ﻪﻘﯿﻗدردﺮﺘﻣ)ﺖﻋﺮﺳ (
15
20 25
25 ...
25 ...
30 ...
30
(ﻪﻘﯿﻗد)نﺎﻣز
20 30
40 50
...
50 ...
63 ...
63
1 Orphan APJ receptor
2 - Lee obesity index
ﯽﺑ زا ﺲﭘ و ﻪﻧﺎﺒﺷ ﯽﯾﺎﺘﺷﺎﻧ و ﯽﻨﯾﺮﻤﺗ ﻪﺴﻠﺟ ﻦﯾﺮﺧآ زا ﺪﻌﺑ ﺖﻋﺎﺳ24 ،ﺮﺗا ﺎﺑ ﯽﺷﻮﻫ
نﻮﺧ ﺐﻠﻗ زا يﺮﯿﮔ ﺪﺷ مﺎﺠﻧا
.
زا ﺲﭘ ﻪﻘﯿﻗد15
ﺖﻋﺮﺳ ﺎﺑ ژﻮﯿﻔﯾﺮﺘﻧﺎﺳ يﺎﻣد رد و ﺪﺷ جاﺮﺨﺘﺳا ﻪﻧﻮﻤﻧ زا ﺎﻤﺳﻼﭘ ،ﻪﻘﯿﻗد رد رود3200
- 70
ﻪﮕﻧ ﻪﺟرد اﺰﯾﻻا ﺖﯿﮐ زا ﺎﻫﺮﯿﻐﺘﻣ ﺶﺠﻨﺳ ياﺮﺑ .ﺪﺷ ﻞﻘﺘﻨﻣ هﺎﮕﺸﯾﺎﻣزآ ﻪﺑ و يراد
ﻦﯿﻠﭘا - ﺺﯿﺨﺸﺗ ﺖﯿﮐ ،تر13
ﺰﮐﻮﻠﮔ ياﺮﺑ يﺮﺘﻣﻮﺘﻓ شور و ﻦﯿﻟﻮﺴﻧا .ﺪﺷ هدﺎﻔﺘﺳا
ياﺮﺑ نﻮﻣزآ زا يرﺎﻣآ تﺎﺒﺳﺎﺤﻣ يﺎﻫ
ﻞﻘﺘﺴﻣt ﺐﯾﺮﺿ و
يرادﺎﻨﻌﻣ ﺢﻄﺳ)ﺪﺷ هدﺎﻔﺘﺳا نﻮﺳﺮﯿﭘ ﯽﮕﺘﺴﺒﻤﻫ /05
مﺮﻧ زا هدﺎﻔﺘﺳاﺎﺑ يرﺎﻣآ تﺎﺒﺳﺎﺤﻣ ﻪﯿﻠﮐ .(0 راﺰﻓا
ﻪﺨﺴﻧSPSS
.ﺖﺳا هﺪﺷ مﺎﺠﻧا16
ﻪﺘﻓﺎﯾ ﺎﻫ
نﻮﻣزآ ﻖﺒﻃ هداد ،K-S
)ﺖﺷاد ﯽﻌﯿﺒﻃ ﻊﯾزﻮﺗ ﺎﻫﺮﯿﻐﺘﻣ ﻪﻤﻫ يﺎﻫ /05
0
>
هداد ﻪﺴﯾﺎﻘﻣ .(P
،داد نﺎﺸﻧ ﯽﻔﯿﺻﻮﺗ يﺎﻫ
هوﺮﮔ نزو ﻦﯿﮕﻧﺎﯿﻣ )ﻦﯾﺮﻤﺗ
/96 29
± /57 زا ﺲﭘ (329 تر ﯽﻧزو ﻦﯿﮕﻧﺎﯿﻣ ﻪﺑ ﮏﯾدﺰﻧ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12
زا ﺲﭘ ﺎﻫ
)ﺖﺳا نﺪﺷ قﺎﭼ /2
29
± /36 )لﺮﺘﻨﮐ هوﺮﮔ نزو ﻦﯿﮕﻧﺎﯿﻣ ﯽﻟو (321 /69
35
± /57 زا ﺲﭘ (398 توﺎﻔﺗ ﻪﺘﻔﻫ12
تر ﯽﻧزو ﻦﯿﮕﻧﺎﯿﻣ ﺎﺑ يرﺎﯿﺴﺑ نﻮﻣزآ ﺞﯾﺎﺘﻧ .ﺖﺷاد نﺪﺷ قﺎﭼ زا ﺲﭘ ﺎﻫ
ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ ﻦﯿﺑ ،داد نﺎﺸﻧ ﻞﻘﺘﺴﻣt
تر ﻦﯿﻠﭘا و ﻦﯿﻟﻮﺴﻧا ،ﺰﮐﻮﻠﮔ ﯽﻨﻌﻣ توﺎﻔﺗ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ و لﺮﺘﻨﮐ هوﺮﮔ قﺎﭼ ﺮﻧ يﺎﻫ
دﻮﺟو يراد
لوﺪﺟ)دراد لﺮﺘﻨﮐ هوﺮﮔ زا ﺮﺘﻤﮐ ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﻦﯿﻟﻮﺴﻧا و ﺰﮐﻮﻠﮔ ﺮﯾدﺎﻘﻣ داد نﺎﺸﻧ ﺎﻫﺮﯿﻐﺘﻣ ﻦﯿﮕﻧﺎﯿﻣ ﻪﺴﯾﺎﻘﻣ .(2
ﻦﯿﻠﭘا ﺮﯾدﺎﻘﻣ و ﺖﺳا -
ﻣزآ ﻖﺒﻃ .ﺖﺳا لﺮﺘﻨﮐ هوﺮﮔ زا ﺮﺘﺸﯿﺑ ﻦﯾﺮﻤﺗ هوﺮﮔ رد13 ﺮﯾدﺎﻘﻣ ﻦﯿﺑ نﻮﺳﺮﯿﭘ ﯽﮕﺘﺴﺒﻤﻫ نﻮ
ﻦﯿﻠﭘا ﯽﯾﺎﻤﺳﻼﭘ -
ﻦﯿﻠﭘا ،ﻦﯿﻟﻮﺴﻧا و13 -
زا ﺲﭘ ﺰﮐﻮﻠﮔ و 13 هﺪﻫﺎﺸﻣ يرادﺎﻨﻌﻣ ﻪﻄﺑار ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12
لوﺪﺟ)ﺪﺸﻧ .(2
لوﺪﺟ نﻮﻣزآ.2 نﻮﺳﺮﯿﭘ ﯽﮕﺘﺴﺒﻤﻫ و ﻞﻘﺘﺴﻣt
نﻮﻣزآ راﺪﻘﻣ
t ﯽﻨﻌﻣ ﺢﻄﺳ يراد
راﺪﻘﻣ t ﯽﻨﻌﻣ ﺢﻄﺳ r
يراد r
ﻦﯿﻠﭘا - 13 /290
2 /041
*0
ﻦﯿﻟﻮﺴﻧا /522
-5 /0001
*0
ﺰﮐﻮﻠﮔ /849
-4 /0001
*0
ﻦﯿﻠﭘا - ﻦﯿﻟﻮﺴﻧا
/498 -0 /07
0
ﻦﯿﻠﭘا - ﺰﮐﻮﻠﮔ
/523
-0 /055
0
* ﯽﻨﻌﻣ ﺢﻄﺳ رد يراد /05
0
ﻪﺠﯿﺘﻧ و ﺚﺤﺑ يﺮﯿﮔ
،ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد ﻦﯿﻠﭘا ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ و ﺪﺷ نزو ﺶﯾاﺰﻓا ﻊﻧﺎﻣ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12
- ار13 تر رد قﺎﭼ يﺎﻫ
.داد ﺶﯾاﺰﻓا وزﺎﺳ
)ﺖﯾار و ﺪﻨﻟﺮﺗﺎﺳ .ﺖﺴﯿﻧ ﻦﺷور ﻦﯿﻠﭘا ﺮﺑ ﯽﺷزرو ﻦﯾﺮﻤﺗ ﺮﯿﺛﺎﺗ ﯽﮕﻧﻮﮕﭼ ﻖﯿﻗد رﺎﮐ ( 2009
نﺎﺸﻧ
ﺮﯿﻐﺘﻣ
هداد زا ﯽﺷﺎﻧ ﻦﯿﻠﭘا ﺶﯾاﺰﻓا لﻮﻟﻮﻧاﺮﭘوﺮﭘ ﺮﮐﻮﻠﺑﺎﺘﺑ ،ﺪﻧا ﯽﻣ ﻢﮐ ار ﺎﻨﺷ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﺖﻋﺎﺳ2
ﺖﺴﯿﻧﻮﮔآ و ﺪﻨﮐ يﺎﻫ
ﺪﯿﻔﺳ زﻮﭙﯾدآ ﺖﻓﺎﺑ رد ﻦﯿﻠﭘا نﺎﯿﺑ ﮏﯾژﺮﻧردآﺎﺘﺑ ﯽﻣ ﺶﯾاﺰﻓا ار
)ﺪﻫد .(4
ﺶﻫوﮋﭘ ﻦﯾا رد تر رد ﻦﯿﻟﻮﺴﻧا و ﺰﮐﻮﻠﮔ ﯽﯾﺎﻤﺳﻼﭘ ﺮﯾدﺎﻘﻣ ﺶﻫﺎﮐ ﺐﺟﻮﻣ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ12
قﺎﭼ ﺮﻧ يﺎﻫ
ﻢﻫ يرﺎﯿﺴﺑ تﺎﻌﻟﺎﻄﻣ ﺎﺑ ﺞﯾﺎﺘﻧ ﻦﯾا .ﺖﺳا هﺪﺷ )ﺖﺳا ﻮﺳ
و2 هﺪﻧﺮﯿﮔ ،ﮏﯾژﺮﻧردآ ﮏﯾﺮﺤﺗ ﺎﺑ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ .(3 يﺎﻫ
ﺎﺘﺑ ﯽﻣ لﺎﻌﻓ ار رﻮﺘﭙﺳﻮﻧردآ2 ) ﺪﻨﮐ
هار زا و (4 ﮏﯾﺮﺤﺗ
GS
، ﯽﻣ لﺎﻌﻓ ارAMPK
نﺪﺷ لﺎﻌﻓ .ﺪﻨﮐ ﻪﻠﻀﻋAMPK
ﯽﻣ ﯽﻟﻮﻠﺳ ﺰﮐﻮﻠﮔ ﺖﺷادﺮﺑ ﺶﯾاﺰﻓا ﺚﻋﺎﺑ )دﻮﺷ
ﻪﺑ (5 نﺎﯿﺑ ،ﯽﺷزرو ﻦﯾﺮﻤﺗ ﺮﺛا رد ،هوﻼﻋ
GLUT4
ﻪﺑ نآ لﺎﻘﺘﻧا و
ﺖﯿﻟﺎﻌﻓ هار زا ﺰﯿﻧ ﯽﺘﻠﮑﺳا ﻪﻠﻀﻋ رد ﯽﯾﺎﻤﺳﻼﭘ يﺎﺸﻏ ﯽﻣ ﺶﯾاﺰﻓاAMPK
ﻞﺧاد ﻪﺑ ﺰﮐﻮﻠﮔ دورو ﻪﺠﯿﺘﻧ رد و ﺪﺑﺎﯾ
لﻮﻠﺳ ﻼﻀﻋ يﺎﻫ نآ زا هدﺎﻔﺘﺳا و ﯽﻧ
ﯽﻣ نﺎﺳآ ﺎﻫ )دﻮﺷ
.(5
ﻪﻌﻟﺎﻄﻣ رد ﺖﺷاﺪﻧ دﻮﺟو يرادﺎﻨﻌﻣ ﻪﻄﺑار ﺎﻫﺮﯿﻐﺘﻣ ﺮﯾدﺎﻘﻣ تاﺮﯿﯿﻐﺗ ﻦﯿﺑ ﺮﺿﺎﺣ
. نآ زا ﺮﯾدﺎﻘﻣ ﻪﮐ ﺎﺟ ﺢﻄﺳ ﮏﯾدﺰﻧP
ﯽﻧدﻮﻣزآ ﻢﮐ داﺪﻌﺗ ،يرادﺎﻨﻌﻣ مﺪﻋ ﻞﯿﻟد ،ﻻﺎﻤﺘﺣا دﻮﺑ يرادﺎﻨﻌﻣ )ﺎﻫ
=7 لﻮﻠﺳ رد ﻦﯿﻠﭘا .ﺪﺷﺎﺑ (n ،ساﺮﮑﻧﺎﭘ يﺎﺘﺑ يﺎﻫ
هار زا ﯽﻣ زﻼﮑﯿﺳ تﻼﯿﻧدآ رﺎﻬﻣ ﺚﻋﺎﺑGi
ﺮﯾدﺎﻘﻣ ﻪﺠﯿﺘﻧ رد دﻮﺷ ﺖﯿﻟﺎﻌﻓ و ﻢﮐ ار ﯽﻟﻮﻠﺳ نوردcAMP
AMPK
لﻮﻠﺳ رد يﺎﻫ
INS-1
ﯽﻣ رﺎﻬﻣ ار (ﺎﺘﺑ ﯽﻟﻮﻠﺳ ﻂﺧ) ﯽﻣ ساﺮﮑﻧﺎﭘ رد ﻦﯿﻟﻮﺴﻧا ﺢﺷﺮﺗ ﻊﻧﺎﻣ ﻦﯿﻠﭘا ،ﺖﯾﺎﻬﻧرد .ﺪﻨﮐ
-
)دﻮﺷ .(6
ﯽﻣ ﺮﻈﻧ ﻪﺑ ﯽﻣ ﯽﻨﯾﺮﻤﺗ ﻪﻣﺎﻧﺮﺑ ﻦﯾا ،ﺪﺳر
ﺶﯿﭘ و ﯽﻗﺎﭼ نﺎﻣرد رد ﺪﻧاﻮﺗ ا يﺮﯿﮔ
.ﺪﺷﺎﺑ ﺮﺛﻮﻣ ﯽﻗﺎﭼ ﻪﺑ ﻪﺘﺴﺑاو ﺖﺑﺎﯾد ز
ﻊﺑﺎﻨﻣ 1.Heinonen MV, Laaksonen DE, Karhu T, Karhunen L, Laitinen T, Kainulainen S, et al. Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis 2009; 19(9):626-633. Cited in Pub Med; PMID 19278844.
2. Kadoglou NP, Vrabas IS, Kapelouzou A, Angelopoulou N: The association of physical activity with novel adipokines in patients with type 2 diabetes. Eur J Intern Med 2012; 23(2):137-142. Cited in Pub Med; PMID 22284243.
3. Tasci I, Erdem G, Ozgur G, Tapan S, Dogru T, Genc H, et al. LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia. Atherosclerosis 2009; 204(1):222-228. Cited in Pub Med; PMID 18845302.
4. Wright D, Sutherland.L. Exercise increase apelin expression in white adipose tissue. Medicin & science in sports & Exercise 2009; 41(5):supplement 1, p38. [http://journals.lww.com/acsm- msse/Citation/2009/05001/Exercise_Increases_Apelin_Expression_In_White.846.aspx]
5. Durante PE, Mustard KJ, Park SH, Winder WW, Hardie DG. Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles. Am J Physiol Endocrinol Metab 2002;
283(1):E178-186. Cited in Pub Med; PMID 12067859.
6. Castan-Laurell I, Dray C, Knauf C, Kunduzova O, Valet P. Apelin, a promising target for type 2 diabetes treatment? Trends Endocrinol Metab 2012; 23(5):234-241. Cited in Pub Med; PMID 22445464.
