ﻪﻠﺠﻣ مﻮﻠﻋ يزار ﯽﮑﺷﺰﭘ هرود
21
، هرﺎﻤﺷ 119 ، ﺖﺸﻬﺒﯾدرا 1393
http://rjms.tums.ac.ir
ﯽﺸﻫوﮋﭘ ﻪﻟﺎﻘﻣ
ﻪﻣﺪﻘﻣ ﯽـﮑﯿﻓوﺮﺗ ﻞـﻣاﻮﻋ نﺎﯿﻣ رد ﻪـﯾﺬﻐﺗ)
رد (يا
CNS ﻦﯿﻓوﺮﺗورﻮــﻧ ﺶــﻘﻧ
و دﺎــﯾز لﺎــﻤﻋا ﺖــﻬﺟ ﻪــﺑ ﺎــﻫ
ﻪﻧﺎﮔﺪﻨﭼ ﯽـﻣ ﺎﻔﯾا ﻪﮐ يا
نآ .ﺖـﺳا ﺮﺗزرﺎـﺑ ﺪـﻨﻨﮐ ﺎـﻫ
ﻢﺘـﺴﯿﺳ رد هﺪـﺷ ﻪﺘﺧﺎﻨﺷ ﯽﮑﯿﻓوﺮﺗ ﻞﻣاﻮﻋ ﻦﯾﺮﺘﻬﺑ هداﻮﻧﺎﺧ ﻪﮐ ﺪﻨﺘﺴﻫ ﯽﺒﺼﻋ ﻢـﻬﻣ ي
ﻪﺘـﺴﺟﺮﺑ و زا يا
ﯽﻣ بﻮﺴﺤﻣ يﺪﯿﺘﭙﭘ ﯽﻠﭘ يﺪﺷر ﻞﻣاﻮﻋ ﺮـﺑ و ﺪﻧﻮﺷ
لﻮﻠﺳ گﺮﻣ و ءﺎﻘﺑ ،ﺮﯿﺜﮑﺗ ﯽﺒـﺼﻋ ﺮﯿﻏ و ﯽﺒﺼﻋ يﺎﻫ
أﺗ ﯽﻣ ﺮﯿﺛ ﺪﻧراﺬﮔ ) 2،1 .(
ﻪﯾﺬﻐﺗ ﻞﻣﺎﻋ هﺪـﺷ ﻖﺘﺸﻣ يا
) ﺰﻐﻣ زا
(BDNF
ﻦﯿﻓوﺮﺗورﻮـﻧ هداﻮﻧﺎﺧ زا ﯽـﻠﭘ يﺎـﻫ
يﺪﯿﺘﭙﭘ ﻪﺤﺷﺮﺘﻣ
ﻪﮐ ﺖﺳا ﺰﯾﺎﻤﺗ رد ﯽﻤﯿﻈﻨﺗ ﯽﺸﻘﻧ
ﻞﮑﺷ ،ﯽﻧورﻮﻧ ﯽـﺴﭘﺎﻨﯿﺳ يﺮﯾﺬﭘ
گﺮـﻣ يﺎﻫﺪـﻧور و
ﯽﻣ ﺎﻔﯾا ﯽﻟﻮﻠﺳ ﺪﻨﮐ
و هﺪـﻧﺮﯿﮔ ﻖـﯾﺮﻃ زا ار دﻮـﺧ ﺮﺛا
ﻦﯾزوﺮـــﯿﺗ ﯽـــﻨﯿﺌﺗوﺮﭘ زﺎـــﻨﯿﮐ
)
Tyrosine kinase receptor (trkB)
(،
ﯽﻣ لﺎﻤﻋا ﯽﻟﻮﻠﺳ ﺢﻄﺳ رد .ﺪﻨﮐ
ﻊﯾزﻮﺗ و يﺰﻐﻣ ﻒﻠﺘﺨﻣ ﻖﻃﺎﻨﻣ رد BDNF
صﻮﺼﺨﺑ
ﻪﮐ ﭗﻤﮐﻮﭙﯿﻫ رد لﻮﺌﺴﻣ
،ﺖـﺳا يﺮﯿﮔدﺎﯾ و ﻪﻈﻓﺎﺣ
ﺖﺳا هﺪﺷ شراﺰﮔ )
3
يﺪـﺷر ﻞـﻣﺎﻋ نﺎـﯿﺑ ناﺰـﯿﻣ ﺮـﺑ ﺎﻣ ﯽﮔﺪﻧز هﻮﯿﺷ.(
،ﺗBDNF
ﺄ ﯽﻣ ﺮﯿﺛ ﺖﻣﻼﺳ ﺎﺑ مأﻮﺗ تﺎﯿﺑﺮﺠﺗ و دراﺬﮔ
ﻂﯿﺤﻣ و ﯽﻔﻃﺎﻋ ﻪـﯾﺬﻐﺗ نﻮـﭽﻤﻫ هﺪـﺷ ﯽـﻨﻏ يﺎـﻫ
ﺎـﺑ ﻦﯿﻓوﺮﺗورﻮﻧ ﻦﯾا حﻮﻄﺳ ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ ﺐﺳﺎﻨﻣ ﯽﻣ ﺖﯿﻤﻫا ﺪﻧﻮﺷ
) 4،5 ،ﺪـﻧدﺮﮐ شراﺰـﮔ نﺎـﻘﻘﺤﻣ .(
ﻪﻌـﺳﻮﺗ رد يرﺎﮔزﺎـﺳ رﺎﮐوزﺎﺳ ﮏﯾ ناﻮﻨﻋ ﻪﺑ ﻪﯾﺬﻐﺗ ترﺎﻬﻣ ﺎﻫ ﯽﻣ بﻮﺴﺤﻣ ﯽﺘﺧﺎﻨﺷ ي ﻞﻣﺎﻋ و دﻮﺷ
يﺎـﻫ
ﻪﯾﺬﻐﺗ ﯽﻣ يا ﻢﯿـﻈﻨﺗ ﻖﯾﺮﻃ زا ﺰﻐﻣ شزادﺮﭘ ﺮﺑ ﺪﻨﻧاﻮﺗ
هﺎﮔرﺬــﮔ هﺪــﻨﻫد لﺎــﻘﺘﻧا يﺎــﻫ
ي لﺎــﻘﺘﻧا ،ﯽﺒــﺼﻋ
هﺎﮔرﺬــﮔ و ﯽﺋﺎــﺸﻏ ﻊﯾﺎــﻣ ،ﯽــﺴﭘﺎﻨﯿﺳ ﺖﯾاﺪــﻫ يﺎــﻫ
* مﺎﻬﻟا ﺪﺳو ي : ﻮﺠﺸﻧاد ي ﺮﺘﮐد ي ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي ﺷزرو ﯽ
، هﺎﮕﺸﻧاد
،ناﺮﻬﺗ
،ناﺮﻬﺗ اﯾ ناﺮ .(لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ*) [email protected]
ﺪﻣﺎﺣ ﺮﮔزﺮﺑ : ﻮﺠﺸﻧاد ي ﺮﺘﮐد ي ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي ﺷزرو ﯽ
، هﺎﮕﺸﻧاد
،ناﺮﻬﺗ
،ناﺮﻬﺗ اﯾ ناﺮ . [email protected]
ﻪﺑﻮﺒﺤﻣ ﺟﺮﺑ ﯿ نﺎ دﺮﻓ : سﺎﻨﺷرﺎﮐ ﺪﺷرا ﻓﯿ ﺰﯾ ژﻮﻟﻮ ي ﺷزرو ﯽ
، هﺎﮕﺸﻧاد
،ناﺮﻬﺗ
،ناﺮﻬﺗ اﯾ ناﺮ . [email protected]
ﺛﺄﺗ ﯿ ﺮ فﺮﺼﻣ ﻞﻤﮑﻣ
ﺎﮕﻣا 3 و اﺬﻏ ي بﺮﭼﺮﭘ ﺮﺑ
دﺎﻘﻣ ﯾﺮ ﻞﻣﺎﻋ ﻓوﺮﺗورﻮﻧ ﯿ
ﮏ ﻖﺘﺸﻣ زا
ﺰﻐﻣ ) (BDNF رد
ﻫ ﯿ ﭗﻤﮐﻮﭙ ر
ت يﺎﻫ ﺮﻧ ﻎﻟﺎﺑ
هﺪﯿﮑﭼ ﻪﻨﯿﻣز و فﺪﻫ :ا ﯾ ﻦ ﺶﻫوﮋﭘ ﺎﺑ فﺪﻫ ﺎﺳﺎﻨﺷ ﯽﯾ تاﺮﺛا ﻟﺎﻤﺘﺣا ﯽ ﻞﻤﮑﻣ ﺎﮕﻣا - 3 و ژر ﯾﻢ اﺬﻏ ﯽﯾ بﺮﭼﺮﭘ ) 50 % ﺑﺮﭼ ﯽ
،عﺎﺒﺷا ﻖﺘﺸﻣ هﺪﺷ زا ﻦﻏور ﻮﺳ ﯾﺎ ( ﺮﺑ دﺎـﻘﻣ ﯾﺮ
ﻞﻣﺎﻋ ﻓوﺮﺗورﻮﻧ ﯿ ﮏ ﻖﺘﺸﻣ زا ﺰﻐﻣ (BDNF) رد
ﻫﯿ ﭗﻤﮐﻮﭙ ر ت يﺎﻫ ﺮﻧ ﻎﻟﺎﺑ ﺎﺑ ﮑﺗ ﯿﻪ ﺮﺑ فﺎﻔﺷ ﺮﺗ ندﺮﮐ ﺶﻘﻧ ﺬﻐﺗ ﯾﻪ رد ﮕﻧﻮﮕﭼ ﯽ ﺪﻌﺗ ﯾ ﻞ ﻞﮑﺷ ﺬﭘ ﯾﺮ ي ﺳﯿ ـﺴﭘﺎﻨ
ﯽ .ﺪﺷمﺎﺠﻧا
شور رﺎﮐ : رد اﯾ ﻦ ﺶﻫوﮋﭘ ﺑﺮﺠﺗ ﯽ 21 ﺮﺳ تر ﺮﻧ داﮋﻧ وﯾ رﺎﺘﺴ )ﺎﺑ ﻦﺳ 8 ﻪﺘﻔﻫ و ﻣﯿ ﮕﻧﺎ ﯿ ﻦ نزو 10 170± مﺮـﮔ (،
رد 3 هوﺮـﮔ وﺎـﺴﻣ ي 7 ﺎـﺗ ﯽﯾ ،لﺮـﺘﻨﮐ اﺬـﻏ
ي اﺬـﻏ ﯾﻢژرﺎﺑهوﺮﮔ .ﺪﻧدﺮﮐهدﺎﻔﺘﺳايزاريزﺎﺳﻦﺴﮐاوومﺮﺳﻪﺴﺳﺆﻣدراﺪﻧﺎﺘﺳاياﺬﻏزالﺮﺘﻨﮐهوﺮﮔ .ﺪﻧﺪﺷ ﯿﻢﺴﻘﺗﯽﻓدﺎﺼﺗرﻮﻃﻪﺑ3ﺎﮕﻣاﻞﻤﮑﻣوبﺮﭼﺮﭘ ﯽﯾ ( نﺪـﺑنزو مﺮﮔﻮـﻠﯿ /ﮐمﺮﮔ-ﯽ ﻣﯿﻠ100)ﻪﻧازور 3،ﺎﮕﻣاﻞﻤﮑﻣهوﺮﮔ .ﺪﻧدﺮﮐﺖﻓﺎﯾردزﺎﺳﺖﺳدبﺮﭼﺮﭘسﺮﺘﺳدردﯽﯾاﺬﻏ ﯾﻢژرﻪﺘﻔﻫ8تﺪﻣﻪﺑ،بﺮﭼﺮﭘ ﻞـﻤﮑﻣ
ﺎﮕﻣا - 3 ﻪﺑ ترﻮﺻ ﮐارﻮﺧ ﯽ ﻪﺑ شور ژاوﺎﮔ رد ﯾ ﺖﻓﺎ ﺪﻧدﺮﮐ . دﺎﻘﻣ ﯾﺮ ﺎﺑBDNF شور ﻻا ﯾاﺰ ﺠﻨﺳ ﯿ هﺪ ﺪﺷ و هداد ﺎﻫ ﺎﺑ هدﺎﻔﺘﺳا زا شور رﺎﻣآ ي ﻟﺎﻧآ ﯿﺰ راو ـﯾ ﺲﻧﺎ ـﯾ
ﮏ .ﺪﻧﺪﺷﻞﯿﻠﺤﺗﻪﻓﺮﻃ
ﯾ ﻪﺘﻓﺎ ﺎﻫ :ﯾ ﻪﺘﻓﺎ يﺎﻫ ﺶﻫوﮋﭘ ﺮﺿﺎﺣ نﺎﺸﻧ
،داد دﺎﻘﻣ ﯾﺮ ﻫﯿBDNF ﭗﻤﮐﻮﭙ ﺲﭘ زا 8
،ﻪﺘﻔﻫ رد هوﺮﮔ اﺬﻏ ي بﺮﭼﺮﭘ ﺖﺒﺴﻧ ﻪﺑ هوﺮـﮔ لﺮـﺘﻨﮐ ﺶﻫﺎـﮐ ﺖـﺷاد ﺎـﻣا
ﺶﻫﺎﮐ ﻨﻌﻣ ﯽ راد دﻮﺒﻧ ) 873 /0
= ( .p رد هوﺮﮔ ﻞﻤﮑﻣ ﺎﮕﻣا 3 رد ﺎﭘﯾ نﺎ ﻪﺘﻔﻫ
،ﻢﺘﺸﻫ دﺎﻘﻣ ﯾﺮ ﻫﯿBDNF ﭗﻤﮐﻮﭙ اﺰﻓا ﯾ ﺶ ﺖﺷاد ﻪﮐ اﯾ ﻦ اﺰﻓا ﯾ ﺶ رد ﺎﻘﻣ ﯾ ﻪﺴ ﺎﺑ هوﺮـﮔ
لﺮﺘﻨﮐ و هوﺮﮔ اﺬﻏ ي بﺮﭼﺮﭘ ﻨﻌﻣ ﯽ يراد دﻮﺑ ) 008 /0
= وp 006 /0
= (p .
ﺘﻧ ﯿ ﻪﺠ ﯿﮔ ﺮ ي : ﺎﺑ ﻪﺟﻮﺗ ﻪﺑ ﺎﻫﺮﺘﻣارﺎﭘ ي ﻞﺻﺎﺣ زا ﻪﻌﻟﺎﻄﻣ ﻪﺑ ﺮﻈﻧ ﻣ ﯽ
،ﺪﺳر ﺬﻐﺗ ﯾﻪ ﻞﻤﮑﻣ ﺎﮕﻣا - 3 ﻣ ﯽ
،ﺪﻧاﻮﺗ اﺰﻓا ﯾ ﺶ دﺎﻘﻣ ﯾﺮ ﻫﯿBDNF ﭙﻤﮐﻮﭙ ﯽ ار ﻪﺑ هاﺮﻤﻫ ﻪﺘـﺷاد
ﺪﺷﺎﺑ .
ﻠﮐ ﯿ هژاوﺪ ﺎﻫ : رﻮﺘﮐﺎﻓ ﻓوﺮﺗورﻮﻧ ﯿ ﮏ ﻖﺘﺸﻣ زا ﺰﻐﻣ ) (،BDNF ﺎﮕﻣا - 3،
اﺬﻏ ي ﺮﭘ
،بﺮﭼ ﻫﯿ ﭗﻤﮐﻮﭙ
:ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ 31
/4 / 92 :شﺮﯾﺬﭘ ﺦﯾرﺎﺗ
28 /7 / 92
هﺪﻨﻨﮐ ي ﺪﻨﺷﺎﺑ راﺬﮔﺮﺛا ﯽﻟﺎﻨﮕﯿﺳ )6
( ﻢﯿﻈﻨﺗ ﺖﻬﺟ و
ار ﯽﺘﺧﺎﻨـﺷ لاوز زا يﺮﯿﮕـﺸﯿﭘ ياﺮﺑ ﺮﺛﺆﻣ يﺎﻫرﺎﮑﻫ
د صﻮﺼﺨﺑ ﺖـﺳا ﺪﻨﻣدﻮﺳ رﺎﯿﺴﺑ يﺪﻨﻤﻟﺎﺳ ر
) 7 ( زا .
ﺶﻫوﮋﭘ ﺮﮕﯾد يﻮﺳ ﺮﯾدﺎﻘﻣ ﻦﯿﺑ طﺎﺒﺗرا يرﺎﯿﺴﺑ يﺎﻫ
ﻦﯿﯾﺎــﭘ نﺎــﺸﻧ ار ﺮــﻤﯾاﺰﻟآ و ﯽﮔدﺮــﺴﻓا و BDNF
هداد ﯽـﻣ ﻪـﯾﺬﻐﺗ ﻪـﮐ ﺪﻧدﺮﮐ نﺎﯿﺑ و ﺪﻧا تاﺮـﺛا ﺪـﻧاﻮﺗ
ﺮﯾدﺎـﻘﻣ ﺮﺑ يﺪﻨﻣدﻮﺳ )ﺪـﺷﺎﺑ ﻪﺘـﺷاد BDNF
8،7
.( ﯽﻣ ﻪﮐ ﯽﯾاﺬﻏ ﻢﯾژر زا ﯽﯾﺎﻫ ﺶﺨﺑ دﺮﮑﻠﻤﻋ ﺮﺑ ﺪﻨﻧاﻮﺗ
ﯽﺘﺧﺎﻨﺷ ﺎﮕﻣا :زا ﺪﻨﺗرﺎﺒﻋ ﺪﻧراﺬﮕﺑ ﺮﯿﺛﺄﺗ
3- ) ،(DHA
ﺪﯿﺋﻮﻧوﻼﻓ ،ﻪﺑﻮﭼدرز )
Flavonoid
( يوﺎـﺣ تﺎﺒﯿﮐﺮﺗ)
ﻮـﺤﻧ ﻪﺑ ﻪﮐ ﺺﺨﺸﻣ ﮏﯿﺗﺎﻣورآ ﻪﻘﻠﺣ ﮏﯾ هدﺮﺘـﺴﮔ
ﯽﻣ ﺖﻓﺎﯾ نﺎﻫﺎﯿﮔ رد يا بﺮﭼﺪﯿـﺳا ،(ﺪﻧﻮـﺷ
،عﺎﺒـﺷا
ﻦﯿﻣﺎﺘﯾو ﻦﯿﻣﺎﺘﯾو ،B
ﻦﯿﻣﺎﺘﯾو ،D
ﯽﺒﯿﮐﺮﺗ و ﻦﯿﻟﻮﮐ ،E
ﻦﯿﻣﺎــﺘﯾو زا ﺎــﻫ
)
E, C
،يور ،ﻢﯿــﺴﻠﮐ ،(ﻦﺗورﺎــﮐ و
ﺳ ﻦﻫآ و ﺲﻣ ،مﻮﯿﻨﻠ )6
ﻪﯾﺬﻐﺗ ﺮﺛﺆﻣ ﻞﻣاﻮﻋ ﻪﻠﻤﺟ زا(.
ﺮﺑ يا ﯽﺑﺮﭼBDNF
ﺎﻫ ﯽـﺑﺮﭼ .ﺪﻨﺘﺴﻫ
بﺮـﭼ يﺎﻫﺪﯿـﺳا ﻞﮑـﺷ ود ﻪـﺑ ﺎـﻫ
) عﺎﺒــــﺷاﺮﯿﻏ
polyunsaturated fatty acids
) ﯽﻣ ﺖﻓﺎﯾ عﺎﺒﺷا و (PUFA
ﻪـﮐ ﯽﺗرﻮـﺻ رد .ﺪﻧﻮـﺷ
هﺮﯿﺠﻧز ي ﺪـﺷﺎﺑ هﺪـﺷ عﺎﺒـﺷا ﯽﻨﺑﺮﮐورﺪﯿﻫ نآ ﻪـﺑ ،
ﯽﻣ هﺪﺷ عﺎﺒﺷا بﺮﭼ ﺪﯿﺳا ﺪﻨﯾﻮﮔ
ﺮﮔا و ﮏـﯾ ياراد
ﺪﺷﺎﺑ ﻪﻧﺎﮔ ود ﺪﻧﻮﯿﭘ ﺪﻨﭼ ﺎﯾ نآ ﻪﺑ ،
بﺮﭼ ﺪﯿﺳا ﺮـﯿﻏ
عﺎﺒﺷا ﯽﻣ ) ﺪﻨﯾﻮﮔ 9 (.
ﯽﻣ ﺮﻈﻧ ﻪﺑ بﺮـﭼ ﺪﯿـﺳا ،ﺪﺳر
ﺮـﺑ ﯽﺗوﺎـﻔﺘﻣ تاﺮـﺛا عﺎﺒﺷا ﺮﯿﻏ بﺮﭼ ﺪﯿﺳا و عﺎﺒﺷا ﺪــﻨﻨﮐ لﺎــﻤﻋا BDNF
) 10 ، 11 ﯽﯾاﺬــﻏ ﻢــﯾژر .(
ﯽــﻣ بﺮــﭼﺮﭘ ،ﯽــﺴﭘﺎﻨﯿﺳ يﺮﯾﺬــﭘ ﻞﮑــﺷ ﺮــﺑ ﺪــﻧاﻮﺗ
ﻪﻈﻓﺎﺣ و ﯽﯾﺎﻀﻓ يﺮﯿﮔدﺎﯾ ﺄﺗ
ﺮـﯿﺛ ﺪـﺷﺎﺑ راﺬـﮔ )
10
.(- ﺎـﮕﻣا بﺮﭼﺪﯿـﺳا زا ﯽﻨﻏ ﯽﯾاﺬﻏ ﻢﯾژر ﮏﯾ ﻪﯾﺬﻐﺗ ﻪـﺑ ،ﯽـﻧژ تﺎـﻤﯿﻈﻨﺗ و نﺎـﺴﻧا ﯽﺘﺧﺎﻨـﺷ ﺪﻨﯾآﺮﻓ رد3 ﻞﮑﺷ و دﺮﮑﻠﻤﻋ يراﺮﻗﺮﺑ تر ﯽـﺴﭘﺎﻨﯿﺳ يﺮﯾﺬـﭘ
ﺎـﻫ
ﯽﻣ ﮏﻤﮐ ﯽﻣ و ،ﺪﻨﮐ
ﻪﺘـﺷاد ﯽﺗﺎـﯿﺣ ﯽـﺸﻘﻧ ﺪﻧاﻮﺗ
- .(6،12)ﺪﺷﺎﺑ
بﺮـﭼﺮﭘ ياﺬـﻏ فﺮـﺼﻣ ﺮﯿﺛﺄﺗ ناﺮﮕﺸﻫوﮋﭘ ﯽﺧﺮﺑ ) -15 13 ا ﻞﻤﮑﻣ فﺮﺼﻣ ﺰﯿﻧ ﺮﮕﯾد ﯽﺧﺮﺑ و ( ﺎـﮕﻣ
3-
) -19 16 ﺮﯾدﺎﻘﻣ ﺮﺑ ار ( راﺮـﻗ ﯽـﺳرﺮﺑ درﻮـﻣBDNF
هداد ﻪـﻨﯿﻣز رد .ﺪﻧا ﺄﺗ
ﺮـﯿﺛ ،بﺮـﭼﺮﭘ ياﺬـﻏ فﺮـﺼﻣ
ﯽﮐﻮﺴﻧﺎﮐ ) نارﺎﮑﻤﻫ و
2007 ﻢﯾژر ﺮﯿﺛﺄﺗ ﯽﺳرﺮﺑ ﻪﺑ (
) زوﺮﺘـﺴﮐد ﺎـﺑ هﺪـﺷ ﯽﻨﻏ بﺮﭼﺮﭘ ياﺬﻏ
High-fat
diets rich in dextrose
) بﺮـﭼﺮﭘ ياﺬﻏ و (HFD
) ﺎـﺑ هﺪـﺷ ﯽـﻨﻏ
High-fat diets rich in sucrose
) ﺮﯾدﺎﻘﻣ ﺮﺑ (HFS
نآ .ﺪﻨﺘﺧادﺮﭘBDNF
شراﺰـﮔ ﺎﻫ
زوﺮﺘﺴﮐد ﺎﺑ هﺪﺷ ﯽﻨﻏ بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ ،ﺪﻧدﺮﮐ ) ﯽـﻨﻌﻣ ﺶﻫﺎـﮐ ﺐﺟﻮﻣ (HFD
حﻮﻄـﺳ راد
BDNF ﯽﻣ ﭗﻤﮐﻮﭙﯿﻫ
ياﺬـﻏ فﺮـﺼﻣ ﻪـﮐ ﯽﻟﺎـﺣ رد ،دﻮـﺷ
) زورﺎﮐﺎــﺳ ﺎــﺑ هﺪــﺷ ﯽــﻨﻏ بﺮــﭼﺮﭘ ﺶﻫﺎــﮐ (HFS
ﯽﻨﻌﻣ ﺮﯾدﺎـﻘﻣ ﺮـﺑ يراد ) داﺪـﻧ نﺎـﺸﻧ BDNF
13
.( ﺎﮑﻤﻫ و ﯽﻨﺘﻟﻮﻣ
ياﺬـﻏ فﺮـﺼﻣ ﺮﯿﺛﺄﺗ ﯽﺳرﺮﺑ ﻪﺑ نار
) زورﺎﮐﺎـﺳ ﺎـﺑ هﺪﺷ ﯽﻨﻏ بﺮﭼﺮﭘ ﺮﯾدﺎـﻘﻣ ﺮـﺑ (HFS
تﺪــﻣ ﻪــﺑ BDNF
2 ، 6 و 24 ﻪــﮐ ﺪــﻨﺘﺧادﺮﭘ هﺎــﻣ
ﺮﯾدﺎﻘﻣ ﺶﻫﺎﮐ ناﺰﯿﻣ ﻦﯾﺮﺘﺸﯿﺑ لﻮـﻃ رد BDNF
زورﺎﮐﺎـﺳ ﺎـﺑ هﺪـﺷ ﯽﻨﻏ بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ لﺎﺳ2 ) )ﺖﻓﺮﮔ ترﻮﺻ (HFS
14 نﺎﺸﻧ نارﺎﮑﻤﻫ و كرﺎﭘ .(
ژوﺮﻧ بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ ،ﺪﻧداد زا ار ﭗﻤﮐﻮﭙﯿﻫ ﺰﻧ
ﺮﯾدﺎـﻘﻣ ﺶﻫﺎـﮐ رﺎـﮐ و زﺎﺳ ﻖﯾﺮﻃ بﻮـﯿﻌﻣ BDNF
ﯽﻣ )ﺪﻨﮐ 15 ﺎــﮕﻣا ﻞــﻤﮑﻣ فﺮــﺼﻣ ﻪــﻨﯿﻣز رد .(
3 و ﮓــﻧﺎﯿﺟ ،
ﻞـﻤﮑﻣ ،ﺪـﻧدﺮﮐ شراﺰﮔ نارﺎﮑﻤﻫ ﺎـﮕﻣا ﯽـﻫد
3-
زا-ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ ﻪﺘﻔﻫ 7 تﺪﻣ ﻪﺑ ژاوﺎﮔ ﻖﯾﺮﻃ ﯽـــﻨﯿﺌﺗوﺮﭘ ﺮﯾدﺎـــﻘﻣ راد ﯽـــﻣBDNF
دﻮـــﺷ ) 16 (
، ﯽــﻨﻌﻣﺮﯿﻏ ﺶﯾاﺰــﻓا نارﺎــﮑﻤﻫ و ﺖــﺑ ﻦﯿــﻨﭽﻤﻫ
راد شﻮﻣ BDNF ﺮﯾدﺎﻘﻣ
ﯽـﻃ ار هدﺮﺴﻓا و ﯽﺘﺑﺎﯾد يﺎﻫ
12 ﺎـﮕﻣا ﻞـﻤﮑﻣ فﺮﺼﻣ ﻪﺘﻔﻫ 3-
ﺪـﻧدﺮﮐ شراﺰـﮔ ،
) 19 نﺎﻤﻫ.(
ﺶﻫوﮋﭘ ﺞﯾﺎﺘﻧ زا ﻪﮐ رﻮﻃ ﺮـﺑ هﺪﺷ مﺎﺠﻧا يﺎﻫ
ﯽﻣ ﺶﻫوﮋﭘ ،ﺪﯾآ ياﺬـﻏ فﺮـﺼﻣ ﺮﯿﺛﺄـﺗ ﻪـﻨﯿﻣز رد ﺎﻫ
ﺎﮕﻣا ﻞﻤﮑﻣ فﺮﺼﻣ و بﺮﭼﺮﭘ 3-
ﺮﯾدﺎـﻘﻣ ﺮﺑ
BDNF ﮔ ﻪﺋارا و ،ﺪﻨﺷﺎﺑﯽﻤﻧ ﻮﺴﻤﻫ و ﻊﻣﺎﺟ ﺐـﺳﺎﻨﻣ ﯽﺷراﺰ
فﺮـﺼﻣ و بﺮـﭼﺮﭘ ياﺬـﻏ فﺮـﺼﻣ ﺮﯿﺛﺄـﺗ ﻪﻨﯿﻣز رد ﺎﮕﻣا ﻞﻤﮑﻣ 3-
ﺮﯾدﺎـﻘﻣ ﺮﺑ ﺮـﻈﻧ ﻪـﺑ ﻞﮑـﺸﻣ BDNF
ﯽﻣ ﻪـﻨﯿﻣز رد يا ﻪـﻌﻟﺎﻄﻣ ﺮـﮕﯾد يﻮـﺳ زا .ﺪـﺳر ي ﺮـﯿﻏ بﺮـﭼ ﺪﯿﺳا و عﺎﺒﺷا بﺮﭼ ﺪﯿﺳا ﺮﯿﺛﺄﺗ ﯽﺳرﺮﺑ
ﺮﯾدﺎﻘﻣ ﺮﺑ عﺎﺒﺷا ،ور ﻦـﯾا زا .ﺪـﺸﻧ هﺪﻫﺎﺸﻣ BDNF
ﯽـﺳرﺮﺑ ﻪـﺑ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد ﺄﺗ
ﺮـﯿﺛ 8 فﺮـﺼﻣ ﻪـﺘﻔﻫ
ﺐـﻟﺎﻏ رد عﺎﺒﺷا ﺮﯿﻏ بﺮﭼ ﺪﯿﺳا و عﺎﺒﺷا بﺮﭼﺪﯿﺳا ﺎـﮕﻣا ﻞﻤﮑﻣ و بﺮﭼﺮﭘ ياﺬﻏ 3
ﺮﯾدﺎـﻘﻣ ﺮـﺑ
BDNF ﺶﻫوﮋﭘ و ،ﺖﺳا هﺪﺷ ﻪﺘﺧادﺮﭘ
ﺦـﺳﺎﭘ لﺎﺒﻧد ﻪﺑ ناﺮﮔ
فﺮـﺼﻣ ﺎـﯾآ ﻪﮐ ﺪﻧا ﺶﺳﺮﭘ ﻦﯾا ﻪﺑ 8
ياﺬـﻏ ﻪـﺘﻔﻫ
ﺎـﮕﻣا ﻞﻤﮑﻣ و بﺮﭼﺮﭘ 3-
ﯽـﻣ ﺮـﯿﯿﻐﺗ ﺐـﺟﻮﻣ ﺪـﻧاﻮﺗ
ﯽﻨﻌﻣ ﺮﯾدﺎﻘﻣ ﺮﺑ يراد
؟دﻮﺷ ﯽﭙﻤﮐﻮﭙﯿﻫBDNF
رﺎﮐ شور ﻪﻌﻟﺎﻄﻣ رد ،ﺮﺿﺎﺣ ﯽﺑﺮﺠﺗ ي
21 داﮋـﻧ ﺮـﻧ تر ﺮﺳ
ﻦﺳ ﺎﺑ) رﺎﺘﺴﯾو 8
ﻪـﺘﻔﻫ نزو ﻦﯿﮕﻧﺎـﯿﻣ و 10
170±
رد ،(مﺮﮔ 3
يوﺎـﺴﻣ هوﺮﮔ 7
ياﺬـﻏ ،لﺮـﺘﻨﮐ ﯽﯾﺎـﺗ
ﺎﮕﻣا ﻞﻤﮑﻣ و بﺮﭼﺮﭘ 3
ﻢﯿـﺴﻘﺗ ﯽﻓدﺎـﺼﺗ ﻞﮑﺷ ﻪﺑ
تر يراﺪﻬﮕﻧ ﻞﺤﻣ يﺎﻣد .ﺪﻧﺪﺷ ﺎﻫ
2 22± ﻪـﺟرد
ي12 ﯽﮑﯾرﺎــﺗ و ﯽﯾﺎﻨــﺷور يﻪــﺧﺮﭼ و داﺮــﮔ ﯽﺘﻧﺎــﺳ ﻪﺘﻋﺎﺳ ياﺮـﺑ ﻪـﻌﻟﺎﻄﻣ عوﺮـﺷ زا ﻞـﺒﻗ تﺎﻧاﻮﯿﺣ .دﻮﺑ رد ﻪـﺘﻔﻫ ﮏﯾ تﺪﻣ ﻪﺑ اﺪﺘﺑا ﺪﯾﺪﺟ ﻂﯾاﺮﺷ ﺎﺑ ﻖﺑﺎﻄﺗ ﺶﻫوﮋـﭘ مﺎـﺠﻧا ﻞـﺤﻣ تﺎـﻧاﻮﯿﺣ هﺎﮕﺸﯾﺎﻣزآ ﻂﯿﺤﻣ ﯽﯾاﺬــﻏ ﻢــﯾژر ﺎــﺑ لﺮــﺘﻨﮐ هوﺮــﮔ .ﺪﻧﺪــﺷ يراﺪــﻬﮕﻧ ﻦـﺴﮐاو و مﺮـﺳ ﻪـﺴﺳﺆﻣ زا هﺪـﺷ ﻪـﯿﻬﺗ دراﺪﻧﺎﺘﺳا .ﺪﻧﺪـﺷ ﻪـﯾﺬﻐﺗ دازآ ﯽﺳﺮﺘﺳد ﻞﮑﺷ ﻪﺑ ،يزار يزﺎﺳ بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ تﺪﻣ ﻪﺑ ار بﺮﭼﺮﭘ ياﺬﻏ ﻢﯾژر ،
8 .ﺪـﻧدﺮﮐ ﺖـﻓﺎﯾرد دازآ ﯽﺳﺮﺘﺳد ﻞﮑﺷ ﻪﺑ و ﻪﺘﻔﻫ
ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ 3
لﻮﻃ رد 8
ﯽﯾاﺬـﻏ ﻢـﯾژر ﻪﺘﻔﻫ
ﻪـﻧازور و دازآ ﯽـﺳﺮﺘﺳد ﻞﮑـﺷ ﻪـﺑ دراﺪﻧﺎﺘﺳا
100 ﯽﻠﯿﻣ
ﻞـﻤﮑﻣ نﺎﺸﻧﺪﺑ نزو مﺮﮔﻮﻠﯿﮐ ﺮﻫ يازا ﻪﺑ مﺮﮔ -ﺎﮕﻣا 3 ﺖـﻓﺎﯾرد ژاوﺎﮔ شور ﻪﺑ و ﯽﮐارﻮﺧ ترﻮﺻ ﻪﺑ
تﺎـــﺒﯿﮐﺮﺗ .ﺪـــﻧدﺮﮐ ﺐـــﺴﺣ ﺮـــﺑ لﺮـــﺘﻨﮐ ﻢـــﯾژر
مﺪﻨﮔ ؛ﻞﻣﺎﺷ مﺮﮔﻮﻠﯿﮐ/مﺮﮔ 50
/ 234 ﻮﺟ ، 66 / 150
، 030/20سﻮﺒــﺳ ،251/30 ترذ ﺎﯾﻮــﺳ ﻪــﻟﺎﺠﻨﮐ ،
05 / 010 ﻪــﺠﻧﻮﯾ ردﻮــﭘ ، 01
/ 002 ﮏــﻤﻧ ، 30
/ 008
، 000/90 ﻦﯿﻣﺎــــﺘﯾو ﯽﺘﻟﻮــــﻣ ﯽﻧﺪــــﻌﻣ داﻮــــﻣ ،
90 / 000 ﻦﯿﻣﺎــــﺘﯾو،
70E
/ 006 ﻦﯿﻣﺎــــﺘﯾو ،
D3 001/67 C ﻦﯿﻣﺎـــﺘﯾو ،001/67 ﮏـــﺸﺧ ﺮﯿـــﺷ ،
10 / 025 ﺖﺷﻮﮔ ردﻮﭘ ، 50
/ 167 ﺮﻔﺻ ﺎﯾﻮﺳ ﻦﻏور و
ﺐـــﺴﺣ ﺮـــﺑ بﺮـــﭼﺮﭘ ﻢـــﯾژر تﺎـــﺒﯿﮐﺮﺗ و دﻮـــﺑ مﺪـﻨﮔ ؛ﻞﻣﺎﺷ مﺮﮔﻮﻠﯿﮐ/مﺮﮔ 5/
234 ﻮـﺟ ، 66 / 140
، 020/00سﻮﺒــﺳ ،042/00 ترذ ﺎﯾﻮــﺳ ﻪــﻟﺎﺠﻨﮐ ،
00 / 150 ﻪــﺠﻧﻮﯾ ردﻮــﭘ ، 01
/ 002 ﮏــﻤﻧ ، 30
/ 008
، 000/90 ﻦﯿﻣﺎــــﺘﯾو ﯽﺘﻟﻮــــﻣ ﯽﻧﺪــــﻌﻣ داﻮــــﻣ ،
90 / 000 ﻦﯿﻣﺎــــﺘﯾو،
70E
/ 006 ﻦﯿﻣﺎــــﺘﯾو ،
D3 001/67 Cﻦﯿﻣﺎـــﺘﯾو ،001/67 ﮏـــﺸﺧ ﺮﯿـــﺷ ،
10 / 025 ﺖﺷﻮﮔ ردﻮﭘ ، 50
/ 167 ﺎﯾﻮﺳ ﻦﻏور و
180 3 ﺎـﮕﻣا ﯽﯾاﺬﻏ ﻢﯾژر .دﻮﺑ
ﺖﮐﺮـﺷ زا ﯽﻫﺎـﻣ ﻦـﻏور)
) (ﺎﻤﮕﯿــﺳ
Menhaden, Sigma Co Germany
(Product Number : F8020)
( بﺮﭼ يﺎﻫﺪﯿﺳا زا
ﺪﯿﺳا ﮏﯿﺘﺴﯾﺮﯿﻣ -6
9 ﺪﯿﺳا ﮏﯿﺘﯿﻤﻟﺎﭘ ،ﺪﺻرد -15
20 ﺪﯿــﺳا ﮏــﯿﺌﻟﻮﺘﯿﻤﻟﺎﭘ ،ﺪــﺻرد -9
14 ،ﺪــﺻرد ﺪﯿﺳا ﮏﯾرﺎﺌﺘﺳا
-3 4 ﺪﯿـﺳا ﮏـﯿﺌﻟوا ،ﺪﺻرد -5
12 ﺪﯿﺳا ﮏﯿﻨﻟﻮﻨﯿﻟ ،ﺪﺻرد 3 ﺪﯿﺳا ﮏﯿﺌﻟﻮﻨﯿﻟ ،ﺪﺻرد ﺪﯿــــــــﺳا ﮏــــــــﯿﻧﻮﺋوﺮﺗﺎﮐدﺎﺘﮐا ،ﺪــــــــﺻرد3 )
Octadecatetraenoic acid
( -2 4 ،ﺪــــــﺻرد
ﺎﺘﻨﭘازﻮﮐا ) ﺪﯿﺳا ﮏﯿﺋﻮﻧا
Eicosapentaenoic acid
) (EPA
ازﻮــــــﮐود و ﺪﯿــــــﺳا ﮏــــــﯿﺋﻮﻧااﺰﮕﻫ
)
Docosahexaenoic acid
) (DHA
هﺪـﺷ ﻞﯿﮑﺸﺗ
ﻪـﺴﺳﺆﻣ ﻪـﺑ طﻮـﺑﺮﻣ دراﺪﻧﺎﺘﺳا ياﺬﻏ اﺪﺘﺑا رد .ﺖﺳا ﺪـﯾدﺮﮔ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ يزار يزﺎﺳ ﻦﺴﮐاو و مﺮﺳ ﺪـﻨﭼ و ﻪـﺴﺳﺆﻣ ﻦـﯾا يرﺎـﮑﻤﻫ ﺎﺑ بﺮﭼﺮﭘ ياﺬﻏ و و ﻪـﯾﺰﺠﺗ ﺞﯾﺎـﺘﻧ .ﺪـﯾدﺮﮔ ﻪﯿﻬﺗ ماد ﻪﯾﺬﻐﺗ ﺺﺼﺨﺘﻣ هداد ﻞﯿﻠﺤﺗ ،لﺮﺘﻨﮐ هوﺮﮔ ﯽﯾاﺬﻏ ﻢﯾژر ؛داد نﺎﺸﻧ ﺎﻫ
25 ،ﯽﺑﺮﭼ يﺮﻟﺎﮐﻮﻠﯿﮐ ﺪﺻرد 18
ﺪﺻرد يﺮﻟﺎﮐﻮﻠﯿﮐ
و ﻦﯿﺌﺗوﺮـﭘ 57
و تارﺪــﯿﻫﻮﺑﺮﮐ يﺮﻟﺎـﮐﻮﻠﯿﮐ ﺪــﺻرد
؛ﺐــﯿﺗﺮﺗ ﻪــﺑ بﺮــﭼﺮﭘ ﯽﯾاﺬــﻏ ﻢــﯾژر 50
، 20 و
30 .(20) دﻮﺑ يﺮﻟﺎﮐﻮﻠﯿﮐ ﺪﺻرد
ﻪﺘﻔﻫ نﺎﯾﺎﭘ رد ندﺮـﮐ اﺪـﺟ ﺎﺑ تﺎﻧاﻮﯿﺣ ،ﻢﺘﺸﻫ ي
هﺮﮑﻤﯿﻧ ود ﺮﻫ زا ﭗﻤﮐﻮﭙﯿﻫ و موﺪﻌﻣ ﺮﺳ و ﺖﺳار ي
ﺖـﯿﮐ ﻞﻤﻌﻟارﻮﺘـﺳد سﺎـﺳا ﺮـﺑ و ﺪﺷ ﻪﺘﺷادﺮﺑ ﭗﭼ ﺖﻬﺟ .ﺪﻧﺪﺷ نژﻮﻤﻫ ﺮﯾدﺎـﻘﻣ تاﺮﯿﯿﻐﺗ ﯽﺳرﺮﺑ مﺎﺠﻧا
ﯽﻨﯿﺌﺗوﺮﭘ .ﺪﺷ هدﺎﻔﺘﺳا اﺰﯾﻻا شور زاBDNF
راﺰــﻓا مﺮــﻧ ﮏــﻤﮐ ﻪــﺑ ﺎــﻫ داد شزادﺮــﭘ وSPSS
هداد ﺰﯿﻟﺎـﻧآ يرﺎـﻣآ نﻮـﻣزآ ﺎﺑ هﺪﺷ يروآ ﻊﻤﺟ يﺎﻫ
نﻮﻣزآ و ﻪﻓﺮﻃ ﮏﯾ ﺲﻧﺎﯾراو ﯽﺒﯿﻘﻌﺗ
و ﻪﯾﺰﺠﺗLSD
ﻪﯿﻠﮐ .ﺪﻧﺪﺷ ﻞﯿﻠﺤﺗ نﻮﻣزآ ي
ﺢﻄـﺳ رد يرﺎـﻣآ يﺎﻫ
ﯽﻨﻌﻣ يراد 05 /0
<
.ﺪﺷ اﺮﺟاp
ﺎﻫ ﻪﺘﻓﺎﯾ ﺮﯾدﺎـﻘﻣ ،ﺪـﺷ هﺪﻫﺎـﺸﻣ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد
BDNF 8 زا ﺲﭘ ﭗﻤﮐﻮﭙﯿﻫ
بﺮـﭼﺮﭘ ياﺬﻏ هوﺮﮔ رد ،ﻪﺘﻔﻫ
ﯽـﻨﻌﻣ ﺮـﯿﯿﻐﺗ لﺮـﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺖـﺷاﺪﻧ يراد
) 873 /0
= ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ رد .(p
3 ﻪـﺘﻔﻫ نﺎﯾﺎﭘ رد
ﺮﯾدﺎﻘﻣ ،ﻢﺘﺸﻫ ﺖـﺷاد ﺶﯾاﺰـﻓا ﭗـﻤﮐﻮﭙﯿﻫ BDNF
ﮐ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﺶﯾاﺰﻓا ﻦﯾا ﻪﮐ راد ﯽﻨﻌﻣ لﺮﺘﻨ
) 008 /0
= بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﺰﯿﻧ و (p
ﯽﻨﻌﻣ ) دﻮﺑ يراد 006
/0
= لوﺪـﺟ) (p
1
،2 رادﻮـﻤﻧ و
1 .(
ﺚﺤﺑ ﻪﺠﯿﺘﻧ و هﻮﻘﻟﺎـﺑ ﻞـﻣاﻮﻋ زا ﯽﯾاﺬـﻏ ﻢـﯾژريﺮﯿﮔ ي
ﺄﺗ ﺮـﯿﺛ ﺮــﺑ راﺬـﮔ
ﺎـﺑ ﯽﻣاﺪـﻧا ﺰﻐﻣ .ﺖﺳا ﯽﻨﻫذ دﺮﮑﻠﻤﻋ و ﺰﻐﻣ ﺖﻣﻼﺳ ،ﯽﮑﯾژﻮــﻟﻮﻓرﻮﻣ ﺦــﺳﺎﭘ رد ﻻﺎــﺑ يﺮﯾﺬــﭘ شزﺎــﺳ ﯽﮑﯿﻟﻮﺑﺎﺘﻣ ﻪـﺑ ﻪـﯾﺬﻐﺗ .ﺖـﺳا ﻂﯿﺤﻣ ﻪﺑ يدﺮﮑﻠﻤﻋ و
ترﺎﻬﻣ ﻪﻌﺳﻮﺗ رد ،ﯽﻄﯿﺤﻣ رﺎﮐوزﺎﺳ ﮏﯾ ناﻮﻨﻋ يﺎﻫﻪــﯾﺬﻐﺗﻞــﻣاﻮﻋ .دﻮــﺷ ﯽــﻣ بﻮــﺴﺤﻣ ﯽﺘﺧﺎﻨــﺷ
يا ﯽــﻣ
ﻢﯿــﻈﻨﺗ ﻖــﯾﺮﻃ زا ﺰــﻐﻣ شزادﺮــﭘ ﺮــﺑ ﺪــﻨﻧاﻮﺗ هﺎﮔرﺬــﮔ هﺪــﻨﻫد لﺎــﻘﺘﻧا يﺎــﻫ
ي راﺬــﮔﺮﺛا ﯽﺒــﺼﻋ
ﺪﻨﺷﺎﺑ )6 ( ﻪﺘﻓﺎﯾ . ﯽـﻨﻌﻣ ﺶﯾاﺰـﻓا ﺮﺿﺎﺣ ﺶﻫوﮋﭘ يﺎﻫ
ﺮﯾدﺎﻘﻣ راد تر ﭗﻤﮐﻮﭙﯿﻫ BDNF
فﺮﺼﻣ زا ﺲﭘ ﺎﻫ
8 ﺎﮕﻣا ﻞﻤﮑﻣ ﻪﺘﻔﻫ 3-
لﺮﺘﻨﮐ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ار
ﻮﻧارﺎﮑﻤﻫ و ﮓﻧﺎﯿﺟ .داد نﺎﺸﻧ بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ و ﯽﻨﻌﻣ ﺶﯾاﺰﻓا نارﺎﮑﻤﻫ و ﺰﻨﯾو ﺮﯾدﺎﻘﻣ راد
ارBDNF
زا ﺲﭘ 7 و 12 ﺎﮕﻣا ﻞﻤﮑﻣ فﺮﺼﻣ ﻪﺘﻔﻫ 3-
شراﺰﮔ
)ﺪﻧدﺮﮐ 16،21 و نارﺎـﮑﻤﻫ و ﺖﮑـﺳﻮﺑ ،ﻞـﺑﺎﻘﻣ رد .(
ﺖﺑ ﻦﯿﻨﭽﻤﻫ فﺮﺼﻣ ،ﺪﻧدﺮﮐ شراﺰﮔ نارﺎﮑﻤﻫ و
10 3- ﺎـﮕﻣا ﻞﻤﮑﻣ هﺎﻣ3 و
ﺮـﯿﯿﻐﺗ ﺐـﺟﻮﻣ ﺐـﯿﺗﺮﺗ ﻪـﺑ ،
ﯽﻨﻌﻣ ﺮﯾدﺎﻘﻣ راد شﻮـﻣ رد BDNF
و ﯽﺘﺑﺎـﯾد يﺎـﻫ ﯽﻤﻧ ﯽﻧﻮﺴﻨﯿﮐرﺎﭘ
)دﻮﺷ 19،18 ﻞـﯿﻟد ﯽﻠﮐ رﻮﻃ ﻪﺑ .(
ﯽـﻣ ار تﺎﻘﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ رد ﺾﻗﺎﻨﺗ فﺮـﺼﻣ ﻪـﺑ ناﻮـﺗ
ﺎـﮕﻣا فﺮﺼﻣ نﺎﻣز تﺪﻣ و توﺎﻔﺘﻣ يﺎﻫزود -
3 ﺎـﯾ و
سﺮﺘﺳا ﺷ دراو يﺎﻫ ﻞﻤﮑﻣ فﺮﺼﻣ نﺎﻣز لﻮﻃ رد هﺪ
زود ،ﺖـﺳا هﺪـﺷ شراﺰـﮔ ﻪﻄﺑار ﻦﯾا رد .داد ﺖﺒﺴﻧ ﺎﮕﻣا ﻦﯿﯾﺎﭘ 3-
ﺮﯾدﺎـﻘﻣ ﺮـﺑ ،نآ تﺪﻣ هﺎﺗﻮﮐ فﺮﺼﻣ و ﯽﻨﻌﻣ ﺮﯿﯿﻐﺗBDNF
ﺖﺷاد ﺪﻫاﻮﺨﻧ يراد )
22
(.8 ﺮﯿﺛﺄـﺗ ي ﻪـﻨﯿﻣز رد ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﺞﯾﺎﺘﻧ ﻪـﺘﻔﻫ
،بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ ﯽﻨﻌﻣ ﺮﯿﯿﻐﺗ
ﺮﯾدﺎـﻘﻣ ﺮﺑ يراد
تر ﭗﻤﮐﻮﭙﯿﻫ BDNF
و ﯽﮐﻮـﺴﻧﺎﮐ .داﺪـﻧ نﺎﺸﻧ ﺎﻫ
فﺮـﺼﻣ ،ﺪﻧدﺮﮐ شراﺰﮔ نارﺎﮑﻤﻫ 14
ياﺬـﻏ ﻪـﺘﻔﻫ
هﺪـﺷ ﯽـﻨﻏ بﺮﭼﺮﭘ ) زوﺮﺘـﺴﮐد ﺎـﺑ
ﺐـﺟﻮﻣ (HFD
ﯽـــﻨﻌﻣ ﺶﻫﺎـــﮐ حﻮﻄـــﺳ راد
ﭗـــﻤﮐﻮﭙﯿﻫBDNF
ﯽﻣ ﯽـﻨﻏ بﺮـﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ ﻪﮐ ﯽﻟﺎﺣ رد ،دﻮﺷ
) زورﺎﮐﺎــﺳ ﺎــﺑ هﺪــﺷ ﯽــﻨﻌﻣ ﺶﻫﺎــﮐ (HFS
ﺮــﺑ يراد
ﺮﯾدﺎﻘﻣ دراﺪﻧ BDNF
) 13 ار توﺎـﻔﺘﻣ ﺞﯾﺎـﺘﻧ ﻪـﮐ .(
ﯽﻣ تر ﯽﯾاﺬـﻏ ﻢـﯾژر توﺎـﻔﺘﻣ تﺎﺒﯿﮐﺮﺗ ﻪﺑ ناﻮﺗ ﺎـﻫ
داد ﺖﺒﺴﻧ )
13 ﻣ ﺶﻫﺎﮐ نارﺎﮑﻤﻫ و ﯽﻨﺘﻟﻮﻣ .(
ﺮﯾدﺎﻘ
فﺮــﺼﻣ ﺮــﺛا رد ارBDNF
2 ، 6 و 24 ياﺬــﻏ هﺎــﻣ
) زورﺎﮐﺎــﺳ ﺎــﺑ هﺪــﺷ ﯽــﻨﻏ بﺮــﭼﺮﭘ شراﺰــﮔ (HFS
ﺮﯾدﺎـﻘﻣ ﺶﻫﺎـﮐ ناﺰﯿﻣ ﻦﯾﺮﺘﺸﯿﺑ ﻪﮐ ﺪﻧدﺮﮐ
BDNF 2 لﻮﻃ رد
ﺎﺑ هﺪﺷ ﯽﻨﻏ بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ لﺎﺳ
) زورﺎﮐﺎﺳ )ﺖﻓﺮﮔ ترﻮﺻ (HFS
14 ﯽـﻠﮐ رﻮـﻃ ﻪﺑ .(
ﯽـﻣ ار تﺎـﻘﯿﻘﺤﺗ ﺞﯾﺎـﺘﻧ رد ﺾﻗﺎـﻨﺗ ﻞﯿﻟد ﻪـﺑ ناﻮـﺗ
ﻫ ﺐﯿﮐﺮﺗ فﺮﺼﻣ فﺮـﺼﻣ نﺎـﻣز تﺪﻣ و توﺎﻔﺘﻣ يﺎ
لوﺪﺟ 1 - ﺮﯾدﺎﻘﻣ رﺎﯿﻌﻣ فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ ﻪﺴﯾﺎﻘﻣ )BDNF
(ng/L ﻪﻌﻟﺎﻄﻣ نﺎﯾﺎﭘ رد هوﺮﮔ ﻪﺳ ﭗﻤﮐﻮﭙﯿﻫ
هوﺮﮔ ﺎﻫ ﻦﯿﮕﻧﺎﯿﻣ
رﺎﯿﻌﻣ فاﺮﺤﻧا لﺎﻤﺘﺣا راﺪﻘﻣ
لﺮﺘﻨﮐ هوﺮﮔ 68
/ 87 45148
* /4 009
/0 /136190 87/42 بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ
ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ 3
41 / 92 22093
/5
لوﺪﺟ 2 - ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ ﺮﯾدﺎﻘﻣLSD
)BDNF (ng/L هوﺮﮔ ﻪﺳ ﭗﻤﮐﻮﭙﯿﻫ
هوﺮﮔ ﺎﻫ ﻦﯿﮕﻧﺎﯿﻣ توﺎﻔﺗ
ﺎﻫ لﺎﻤﺘﺣا راﺪﻘﻣ
لﺮﺘﻨﮐ هوﺮﮔ بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ
ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ 25714 3
/0/472857 873 -
/0008*
/0 3 ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ بﺮﭼﺮﭘ ياﺬﻏ هوﺮﮔ
لﺮﺘﻨﮐ هوﺮﮔ 98571
/4 - /025714 - 006*
/0/0873
ﺎﮕﻣا ﻞﻤﮑﻣ هوﺮﮔ 3
ياﺬﻏ هوﺮﮔ بﺮﭼﺮﭘ
لﺮﺘﻨﮐ هوﺮﮔ 98571
/472857 /4 006*
/0008*
/0
* ﯽﻨﻌﻣ توﺎﻔﺗ هوﺮﮔ ﻦﯿﺑ راد ﺎﻫ
رادﻮﻤﻧ 1 - تاﺮﯿﯿﻐﺗ ﻦﯿﺌﺗوﺮﭘ ترBDNF
هوﺮـﮔ رد ﻎﻟﺎـﺑ ﺮـﻧ يﺎـﻫ يﺎـﻫ
ﻪﻌﻟﺎﻄﻣ درﻮﻣ
شراﺰـﮔ ﻪـﻄﺑار ﻦـﯾا رد .داد ﺖﺒـﺴﻧ بﺮﭼﺮﭘ ياﺬﻏ ﺮﯾدﺎـﻘﻣ ﺮـﺑ ،نآ تﺪـﻣ هﺎـﺗﻮﮐ فﺮـﺼﻣ ،ﺖـﺳا هﺪﺷ
ﺖﺷاد ﺪﻫاﻮﺧ يﺮﺘﻤﮐ تاﺮﯿﺛﺄﺗ BDNF
) 13
(. 3-ﺎﮕﻣا ﯽﯾاﺬﻏ ﻢﯾژر
ﯽـﻣ بﺮـﭼﺮﭘ ياﺬﻏ و ﺪـﻨﻧاﻮﺗ
ﻞﻤﻋ لﺎﻨﮕﯿـﺳ ﺮـﺑ ارBDNF
ﯽﺘﻓﺎـﯾرد يﺎـﻫ
TrkB ﻦﯿــﺴﭘﺎﻨﯿﺳ ﺖــﯿﻟﺎﻌﻓ ﻪــﺑ ﺮــﺠﻨﻣ و ﺪــﻨﻫد ﺮــﯿﯿﻐﺗ
1 Synapsin 1)
رد ﻪﮐ ﯽﺒﺼﻋ ﻪﻧﺎﯾﺎﭘ ﻦﯿﺌﺗوﺮﭘ ﻮﻔﺴﻓ) (
و ﯽﻧﻮـﺴﮐآ لﻮـﻃ دﺎـﯾدزا ،ﺎﻫﺮﺘﯿﻤـﺴﻧاﺮﺗوﺮﻧ ﺶﯾﺎﻫر ﯽﻣ ﺮﯿﮔرد ﯽﺴﭘﺎﻨﯿﺳ لﺎﺼﺗا ﻆﻔﺣ و (دﻮـﺷ
Cyclic
AMP response element binding protein kinase
) رد هﺪـﺷ يرادﺮـﺑ ﻪﺨـﺴﻧ ﻞﻣﺎﻋ) (CREB
ﻓﺎﺣ و يﺮﯿﮔدﺎﯾ (ﯽـﻧژ نﺎﯿﺑ ﻢﻬﻣ هﺪﻨﻨﮐ ﻞﯾﺪﻌﺗ و ﻪﻈ
ﻦﯿﺴﭘﺎﻨﯿﺳ .ﺪﻧﻮﺷ 1
و ﯽﻣ هﺪﺷ لﺎﻌﻓ CREB
ﺪـﻨﻧاﻮﺗ
و ﺪﻨﺷﺎﺑ ﻪﺘﺷاد ﺖﮐﺮﺷ ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ ﺶﯾاﺰﻓا رد ﯽﯾاﺬـﻏ ﻞـﻤﮑﻣ ﺮﯿﺛﺄـﺗ رد ار ﯽﺗﺎﯿﺣ يا ﻪﻄﺳاو ﺶﻘﻧ -ﺎﮕﻣا 3 ﻞﮑﺷ ﺮﺑ بﺮﭼﺮﭘ ياﺬﻏ و و ﯽﺴﭘﺎﻨﯿﺳ يﺮﯾﺬﭘ
ﺪﻧراﺬﮔ ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ )
5،23
.( ﻪـﻨﯿﻣز رد ﺎـﻫﺶﻫوﮋﭘ ﺮﯿﺛﺄـﺗ ي
يﺎﻫﺪﯿـﺳا ﻪـﯾﺬﻐﺗ
ﻦﯿﻓﺮﺗورﻮــﻧ ﺮــﺑ بﺮــﭼ ﺞﯾﺎــﺘﻧ و ﺖــﺳا دوﺪــﺤﻣ ﺎــﻫ
ﯽﻣ توﺎﻔﺘﻣ ﺰﯿﻧ تﺎﻌﻟﺎﻄﻣ توﺎـﻔﺘﻣ تﺎـﺒﯿﮐﺮﺗ .ﺪـﺷﺎﺑ
ﻞـﻤﮑﻣ فﺮـﺼﻣ نﻮﮔﺎـﻧﻮﮔ يﺎﻫزود و بﺮﭼﺮﭘ ياﺬﻏ -ﺎﮕﻣا 3 ﺮﯾدﺎﻘﻣ ﺮﺑ ﺪـﻧراد ﯽﺗوﺎﻔﺘﻣ تاﺮﯿﺛﺄﺗ BDNF
. سﺮﺘــﺳا ﺮــﮕﯾد يﻮــﺳ زا
نﺎــﻣز رد هﺪــﺷ دﺎــﺠﯾا
ﻪﺑﺎﺟ ﺮـﻫ رد ﺎﻫ ﻪﻧﻮﻤﻧ داﺪﻌﺗ و تﺎﻧاﻮﯿﺣ ﯽﯾﺎﺟ ،هوﺮـﮔ
ﺖﯾدوﺪﺤﻣ ﻪﻠﻤﺟ زا ﺮـﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ يﺎﻫ
.ﺪﻨﺘـﺴﻫ
رد ﯽﻣ دﺎﻬﻨﺸﯿﭘ نﺎﯾﺎﭘ
ﺮﯿﺛﺄـﺗ ﻪـﻨﯿﻣز رد ﯽﺗﺎـﻘﯿﻘﺤﺗ دﻮﺷ
ﻒﻠﺘﺨﻣ تﺎﺒﯿﮐﺮﺗ ﺎﺑ بﺮﭼﺮﭘ ياﺬﻏ فﺮﺼﻣ يﺎﻫزود و
ﺎـﮕﻣا ﻞﻤﮑﻣ فﺮﺼﻣ توﺎﻔﺘﻣ 3-
ﺮﯾدﺎـﻘﻣ ﺮـﺑ
BDNF .دﻮﺷ مﺎﺠﻧا
ﻞـﻤﮑﻣ فﺮـﺼﻣ ،ﺮـﺿﺎﺣ ﺶﻫوﮋـﭘ ﺞﯾﺎﺘﻧ سﺎﺳا ﺮﺑ ﺎﮕﻣا 3 ﺮﯾدﺎـﻘﻣ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ ـﭙﯿﻫBDNF
ﯽﭙﻤﮐﻮ
ﯽﻣ ﺮﻈﻧ ﻪﺑ ﻪﻧﻮﮔ ﻦﯾا اﺬﻟ ؛ﺪﺷ ناﺰﯿﻣ ﺶﯾاﺰﻓا ﻪﮐ ﺪﺳر
ﺎﮕﻣا فﺮﺼﻣ 3
ﯽـﻣ ﻪـﻧازور ياﺬـﻏ رد ﺐـﺟﻮﻣ ﺪـﻧاﻮﺗ
ﺮﯾدﺎﻘﻣ ﺶﯾاﺰﻓا و ﺰـﻐﻣ لاوز زا يﺮﯿﮕﺸﯿﭘ و BDNF
و ﯽﮔدﺮـﺴﻓا ،ﺮﻤﯾاﺰﻟآ ﻞﺜﻣ ﯽﯾﺎﻫرﺎﻤﯿﺑ عﻮﯿﺷ ﺶﻫﺎﮐ هﺮﯿﻏ .ددﺮﮔ ﻊﺑﺎﻨﻣ
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The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus
*Elham Vosadi, PhD student of Sport Physiology, Tehran University, Tehran, Iran (*Corresponding author).
Hamed Barzegar, PhD student of Sport Physiology, Tehran University, Tehran, Iran, [email protected] Mahboobe Borjianfard, MSc of Sport Physiology, Tehran University, Tehran, Iran, [email protected]
Abstract
Background: This study was to examine the effects of omega-3 supplementation and high- fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus.
Methods: Twenty one Wistar rats were divided into three groups: (1) regular diet (RD), (2) high-fat (HF) diet and (3) Docosahexaenoic acid (DHA) diet. RD group was regarded as control. Animals in HF groups were exposed to the HF diet for 8 weeks and animals in DHA groups were treated with 100/mg/kg/day of DHA via oral gavage for 8 weeks. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data was analyzed by one- way ANOVA. When appropriate, further differences were analyzed by LSD post hoc test.
Statistical differences were considered significant at p<0.05.
Results: The results showed that the HF diet had no significant effect in BDNF protein level (p=0.873), while the DHA diet revealed a significant increase in BDNF protein level comparison with the RD (p=0.008) and HF (p=0.006) group
Conclusion: According to results of the present study, DHA diet can increase the amount of hippocampus BDNF protein level.
Keywords: Brain-derived neurotrophic factor (BDNF), Omega-3 Supplementation, High-fat diet, Hippocampus
