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Hubungan Kadar Vascular Endothelial Growth Factor (VEGF)
Serum dengan Skor Psoriasis Area And Severity Index (PASI)
pada penderita psoriasis vulgaris
di RSUP. H. Adam Malik Medan
Grace, Chairiyah Tanjung, Irma D. Roesyanto – Mahadi Departemen Ilmu Kesehatan Kulit dan Kelamin,
Fakultas Kedokteran Universitas Sumatera Utara / RSUP Haji Adam Malik Medan, Indonesia
Abstrak
Latar Belakang :
Psoriasis adalah suatu penyakit kulit yang multifaktorial dengan patogenesis yang kompleks. Vascular endothelial growth factor (VEGF) merupakan salah satu faktor kontribusi dari patogenesis psoriasis vulgaris.
Tujuan :
Untuk mengetahui korelasi antara kadar VEGF dan tingkat keparahan psoriasis (yang diekspresikan dengan Psoriasis Area and Severity Index, PASI)
Metode :
Serum diambil dari 20 penderita dengan psoriasis vulgaris dengan analisis ELISA untuk mengevaluasi kadar dari VEGF. Tingkat keparahan psoriasis ditentukan dengan Psoriasis Area and Severity Index (PASI)
Hasil :
Dua puluh sampel di dominasi jenis kelamin laki-laki; median usia 46 tahun; frekuensi tertinggi pada dekade empat dan enam. Median PASI 9,6 (Max-Min: 34,10 – 1,80). Median konsentrasi VEGF serum 537,09 pg/mL (Max-Min: 1696,67 – 30,15). Kadar VEGF serum berkorelasi secara signifikan dengan skor PASI (r=0.527, P<0.05).
Kesimpulan :
Terdapat hubungan antara kadar VEGF serum dan keparahan penyakit psoriasis, yang dapat digunakan sebagai penanda dari keparahan psoriasis. Modulasi dari produksi VEGF dapat menunjukkan potensi strategi terapeutik untuk psoriasis
Kata kunci : Psoriasis vulgaris – VEGF - PASI
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Correlation of Serum Vascular Endothelial Growth Factor
(VEGF) to Psoriasis Area And Severity Index (PASI) Score in
psoriasis vulgaris in Adam Malik Hospital Medan
Grace, Chairiyah Tanjung, Irma D. Roesyanto - MahadiDepartment of Dermatology and Venereology,
Faculty of Medicine, Universitas Sumatera Utara / Haji Adam Malik General Hospital Medan, Indonesia
Abstract Background:
Psoriasis is a multi-factorial skin disease with a complex pathogenesis. Vascular endothelial growth factor (VEGF) have been reported to be one of the contributory factors to the pathogenesis of psoriasis vulgaris.
Objective:
The aimed of the study is to investigate the correlation between the levels of VEGF and psoriasis severity (as expressed by psoriasis area severity index, PASI).
Methods:
Sera were collected from twenty patients with psoriasis vulgaris for ELISA analysis to evaluate levels of VEGF. The severity of psoriasis was determined by the Psoriasis Area and Severity Index (PASI)
Results:
In nine months we had twenty samples with male predominance; Median age 46 years old.; the highest frequency was in fourth to six decade of life. Median PASI 9,6 (Max-Min: 34,10 – 1,80). Serum VEGF concentration Median 537,09 pg/mL (Max-Min : 1696,67 – 30,15). In addition, serum levels of VEGF significantly correlated with PASI score (r=0.527, P<0.05).
Conclusion:
These findings suggest an association between serum levels of VEGF and psoriasis disease severity, which can be recognized as markers of the psoriasis severity. The modulation of VEGF production may represent a therapeutic potential strategy for psoriasis
Keywords : Psoriasis vulgaris – VEGF - PASI
