Lembar Penjelasan Kepada Calon Subjek Penelitian
Dengan hormat,
Saya dr Shahrul Rahman, Sp.PD saat ini sedang menjalani pendidikan S3
kedokteran program studi S3 ilmu kedokteran fakultas kedokteran
Universitas Sumatera Utara. Saya sedang melakukan penelitian yang
berjudul EFEK EKSTRAK BUNCIS (P
haseolus vulgaris
L
)
TERHADAP
KADAR
LDL
DAN
OxLDL
SERTA
KAITANNYA
DENGAN
POLIMORFISME
GEN
LOX-
1 3‟UTR188CT SEBAGAI UPAYA
PREVENTIF RISIKO ATEROSKLEROSIS.
Aterosklerosis adalah merupakan gangguan pembuluh darah dijantung
yang akan dapat berakibat fatal pada penderitanya. Oleh karena itu,
pencegahan terhadap terjadi dan berkembangnya aterosklerosis
merupakan hal yang penting.
Buncis yang sudah dikenal sebagai sayuran yang sering dikonsumsi
sehari-hari,
diyakini
mempunyai
efek
yang
dapat
mencegah
berkembangnya proses pengerasan dinding pembuluh darah. Sehingga
tujuan penelitian ini selain untuk mengetahui keberadaan gen LOX-1
3‟UTR188CT, juga untuk mendapatkan efek pencegahan dari buncis
terhadap berkembangnya proses tersebut. Manfaat bagi peserta adalah
selain dapat mengetahui parameter laboratorium juga dapat mengetahui
efek baik buncis.
Adapun proses penelitian yang Bapak/Ibu/Sdr/i akan ikuti dalam penelitian
1. Pengambilan darah dengan menggunakan jarum suntik sebanyak
10 cc (1 jarum suntik 10 cc penuh)
2. Tujuan pengambilan darah adalah untuk melakukan pemeriksaan
profil lemak, kadar OxLDL dan polimorfisme
gen 3‟UTR188CT
3. Pengambilan darah akan dilakukan sebanyak 2 kali, yaitu periode
sebelum perlakuan dan sesudah perlakuan
4. Darah yang diambil akan diperiksa pada Laboratorium Klinik
Prodia Medan dan Eijkman Institute, Jakarta.
Sebagai informasi, efek sampng pengambilan darah hampir tidak ada
karena dilakukan sesuai dengan prosedur pengambilan darah yang steril.
Jika Bapak/Ibu/Sdr/i mengalami efek samping seperti pembengkakan di
daerah tempat pengambilan darah, maka peneliti wajib memberikan
pengobatan yaitu dengan menekan dan mengompres dengan kain kasa
yang telah dibasahi oleh alkohol 70%.
Partisipasi Bapak/Ibu/Sdr/i bersifat suka rela dan tanpa paksaan. Setiap
data yang ada dalam penelitian ini dirahasiakan dan digunakan untuk
kepentingan penelitian. Untuk mengikuti penelitian ini Bapak/Ibu/Sdr/i
tidak akan dipungut biaya apapun.
Bila Bapak/Ibu/Sdr/i bersedia untuk menjadi subyek penelitian, mohon
untuk mengisi dan menandatangani lembar persetujuan yang telah kami
sediakan.
Jika Bapak/Ibu/Sdr/i membutuhkan penjelasan lebih lanjut, maka dapat
Terima kasih saya ucapkan kepada Bapak/Ibu/Sdr/i yang telah bersedia
ikut berpartisipasi pada penelitian ini. Keikutsertaan Bapak/Ibu/Sdr/i dalam
penelitian ini akan menyumbangkan sesuatu yang berguna bagi ilmu
pengetahuan.
Medan, ...2013
SURAT PERSETUJUAN SETELAH PENJELASAN
(INFORMED CONSENT)
Saya yang bertanda tangan di bawah ini :
Nama
: ………
Alamat
: ………
Umur
: …... tahun
Jenis Kelamin : Pria / Wanita
Setelah mempelajari dan mendapat penjelasan yang sejelas-jelasnya
mengenai penelitian yang berjudul : EFEK EKSTRAK BUNCIS (P
haseolus
vulgaris
L
)
TERHADAP KADAR LDL DAN OxLDL SERTA KAITANNYA
DENGAN POLIMORFISME GEN LOX-
1 3‟UTR188CT SEBAGAI UPAYA
PREVENTIF RISIKO ATEROSKLEROSIS dan setelah mengetahui dan
menyadari sepenuhnya tentang risiko efek samping yang mungkin akan
terjadi, dengan ini saya menyatakan bahwa saya bersedia mengikuti
prosedur penelitian dengan sadar, sukarela dan tanpa paksaan untuk
menjadi subyek dalam penelitian ini.
Medan, ...2013
Yang membuat pernyataan
Peneliti
Oneway
Post Hoc Tests
Descriptives
Umur (tahun)
9 43.00 4.555 1.518 39.50 46.50 36 50
10 38.20 5.308 1.679 34.40 42.00 31 48
7 44.43 4.614 1.744 40.16 48.70 37 50
9 38.78 5.167 1.722 34.81 42.75 30 46
35 40.83 5.426 .917 38.96 42.69 30 50
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
Umur (tahun)
.122
3
31
.946
Levene
Statistic
df1
df2
Sig.
ANOVA
Umur (tahun)
240.102
3
80.034
3.261
.035
760.870
31
24.544
1000.971
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: Umur (tahun) LSD
4.800* 2.276 .043 .16 9.44 -1.429 2.497 .571 -6.52 3.66 4.222 2.335 .080 -.54 8.99 -4.800* 2.276 .043 -9.44 -.16 -6.229* 2.441 .016 -11.21 -1.25 -.578 2.276 .801 -5.22 4.06 1.429 2.497 .571 -3.66 6.52 6.229* 2.441 .016 1.25 11.21 5.651* 2.497 .031 .56 10.74 -4.222 2.335 .080 -8.99 .54 .578 2.276 .801 -4.06 5.22 -5.651* 2.497 .031 -10.74 -.56 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
(I-J) Std. Error Sig. Lower Bound Upper Bound 95% Confidence Interval
Oneway
Post Hoc Tests
Descriptives
KGD
9 87.00 8.675 2.892 80.33 93.67 77 106
10 87.70 8.166 2.582 81.86 93.54 76 107
7 80.00 7.616 2.878 72.96 87.04 73 94
9 86.78 7.032 2.344 81.37 92.18 77 97
35 85.74 8.114 1.372 82.96 88.53 73 107
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
KGD
.037
3
31
.990
Levene
Statistic
df1
df2
Sig.
ANOVA
KGD
293.030
3
97.677
1.556
.220
1945.656
31
62.763
2238.686
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: KGD LSD
-.700 3.640 .849 -8.12 6.72 7.000 3.992 .089 -1.14 15.14 .222 3.735 .953 -7.39 7.84 .700 3.640 .849 -6.72 8.12 7.700 3.904 .058 -.26 15.66 .922 3.640 .802 -6.50 8.35 -7.000 3.992 .089 -15.14 1.14 -7.700 3.904 .058 -15.66 .26 -6.778 3.992 .100 -14.92 1.36 -.222 3.735 .953 -7.84 7.39 -.922 3.640 .802 -8.35 6.50 6.778 3.992 .100 -1.36 14.92 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
Oneway
Post Hoc Tests
Descriptives
Ureum
9 20.89 5.622 1.874 16.57 25.21 15 33
10 20.80 5.594 1.769 16.80 24.80 13 29
7 19.43 2.370 .896 17.24 21.62 16 22
9 18.22 4.577 1.526 14.70 21.74 10 25
35 19.89 4.788 .809 18.24 21.53 10 33
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
Ureum
1.685
3
31
.191
Levene
Statistic
df1
df2
Sig.
ANOVA
Ureum
43.784
3
14.595
.615
.611
735.759
31
23.734
779.543
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: Ureum LSD
.089 2.238 .969 -4.48 4.65 1.460 2.455 .556 -3.55 6.47 2.667 2.297 .254 -2.02 7.35 -.089 2.238 .969 -4.65 4.48 1.371 2.401 .572 -3.53 6.27 2.578 2.238 .258 -1.99 7.14 -1.460 2.455 .556 -6.47 3.55 -1.371 2.401 .572 -6.27 3.53 1.206 2.455 .627 -3.80 6.21 -2.667 2.297 .254 -7.35 2.02 -2.578 2.238 .258 -7.14 1.99 -1.206 2.455 .627 -6.21 3.80 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
Oneway
Post Hoc Tests
Descriptives
Creatinin
9 .8367 .25725 .08575 .6389 1.0344 .59 1.41
10 .8040 .26222 .08292 .6164 .9916 .52 1.33
7 .7614 .16088 .06081 .6126 .9102 .60 1.10
9 .8289 .17934 .05978 .6910 .9667 .59 1.08
35 .8103 .21607 .03652 .7361 .8845 .52 1.41
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
Creatinin
.867
3
31
.468
Levene
Statistic
df1
df2
Sig.
ANOVA
Creatinin
.026
3
.009
.175
.912
1.561
31
.050
1.587
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: Creatinin LSD
.03267 .10310 .753 -.1776 .2429 .07524 .11308 .511 -.1554 .3059 .00778 .10578 .942 -.2080 .2235 -.03267 .10310 .753 -.2429 .1776 .04257 .11058 .703 -.1830 .2681 -.02489 .10310 .811 -.2352 .1854 -.07524 .11308 .511 -.3059 .1554 -.04257 .11058 .703 -.2681 .1830 -.06746 .11308 .555 -.2981 .1632 -.00778 .10578 .942 -.2235 .2080 .02489 .10310 .811 -.1854 .2352 .06746 .11308 .555 -.1632 .2981 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
Oneway
Post Hoc Tests
Descriptives
Ox-LDL (pre)
9 238.33 67.067 22.356 186.78 289.89 134 317
10 144.50 94.151 29.773 77.15 211.85 44 277
7 251.14 58.453 22.093 197.08 305.20 127 297
9 225.44 76.054 25.351 166.98 283.91 77 302
35 210.77 85.171 14.397 181.51 240.03 44 317
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
Ox-LDL (pre)
2.444
3
31
.083
Levene
Statistic
df1
df2
Sig.
ANOVA
Ox-LDL (pre)
64102.592
3
21367.531
3.629
.024
182539.6
31
5888.374
246642.2
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: Ox-LDL (pre) LSD
93.833* 35.258 .012 21.92 165.74 -12.810 38.671 .743 -91.68 66.06 12.889 36.174 .724 -60.89 86.67 -93.833* 35.258 .012 -165.74 -21.92 -106.643* 37.816 .008 -183.77 -29.52 -80.944* 35.258 .029 -152.85 -9.04 12.810 38.671 .743 -66.06 91.68 106.643* 37.816 .008 29.52 183.77 25.698 38.671 .511 -53.17 104.57 -12.889 36.174 .724 -86.67 60.89 80.944* 35.258 .029 9.04 152.85 -25.698 38.671 .511 -104.57 53.17 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
(I-J) Std. Error Sig. Lower Bound Upper Bound 95% Confidence Interval
Oneway
Post Hoc Tests
Descriptives
Ox-LDL (post)
9 265.78 72.475 24.158 210.07 321.49 84 329
10 261.50 54.062 17.096 222.83 300.17 163 313
7 302.43 20.582 7.779 283.39 321.46 276 331
9 283.00 53.796 17.932 241.65 324.35 184 338
35 276.31 54.877 9.276 257.46 295.17 84 338
Dosis 40 mg Dosis 80 mg Dosis 120 mg Placebo Total
N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for
Mean
Minimum Maximum
Test of Homogeneity of Variances
Ox-LDL (post)
1.244
3
31
.311
Levene
Statistic
df1
df2
Sig.
ANOVA
Ox-LDL (post)
8369.773
3
2789.924
.920
.443
94019.770
31
3032.896
102389.5
34
Between Groups
Within Groups
Total
Sum of
Squares
df
Mean Square
F
Sig.
Multiple Comparisons
Dependent Variable: Ox-LDL (post) LSD
4.278 25.304 .867 -47.33 55.89 -36.651 27.754 .196 -93.25 19.95 -17.222 25.961 .512 -70.17 35.73 -4.278 25.304 .867 -55.89 47.33 -40.929 27.140 .142 -96.28 14.42 -21.500 25.304 .402 -73.11 30.11 36.651 27.754 .196 -19.95 93.25 40.929 27.140 .142 -14.42 96.28 19.429 27.754 .489 -37.18 76.03 17.222 25.961 .512 -35.73 70.17 21.500 25.304 .402 -30.11 73.11 -19.429 27.754 .489 -76.03 37.18 (J) Pemberian obat
Dosis 80 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 120 mg Placebo Dosis 40 mg Dosis 80 mg Placebo Dosis 40 mg Dosis 80 mg Dosis 120 mg (I) Pemberian obat
Dosis 40 mg
Dosis 80 mg
Dosis 120 mg
Placebo
Mean Difference
NPar Tests (Dosis 40 mg)
T-Test
One-Sample Kolmogorov-Smirnov Test
9 214.11 64.449 .237 .110 -.237 .712 .691
9 228.11 48.048 .266 .266 -.190 .799 .547
9 137.67 48.003 .145 .120 -.145 .434 .992 9 137.44 28.076 .121 .121 -.106 .364 .999 9 45.67 18.527 .177 .177 -.132 .532 .940 9 47.44 14.492 .166 .166 -.102 .499 .965
9 158.11 95.241 .189 .189 -.124 .567 .904
9 163.44 86.986 .190 .179 -.190 .571 .900
9 238.33 67.067 .188 .168 -.188 .564 .909 9 265.78 72.475 .287 .192 -.287 .860 .450 Kolesterol
(pre) Kolesterol (post) LDL (pre) LDL (post) HDL (pre) HDL (post) Trigiserida (pre) Trigiserida (post) Ox-LDL (pre) Ox-LDL (post)
N Mean Std. Deviation Normal Parametersa,b
Absolute Positive Negative Most Extreme Differences
Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)
Test distribution is Normal. a.
Calculated from data. b.
Paired Samples Statistics
214.11 9 64.449 21.483 228.11 9 48.048 16.016 137.67 9 48.003 16.001 137.44 9 28.076 9.359 45.67 9 18.527 6.176 47.44 9 14.492 4.831 158.11 9 95.241 31.747 163.44 9 86.986 28.995 238.33 9 67.067 22.356 265.78 9 72.475 24.158 Kolesterol (pre)
Kolesterol (post) Pair
1
LDL (pre) LDL (post) Pair
2
HDL (pre) HDL (post) Pair
3
Trigiserida (pre) Trigiserida (post) Pair
4
Ox-LDL (pre) Ox-LDL (post) Pair
5
Mean N Std. Deviation
Std. Error Mean
Paired Samples Correlations
9 .852 .004
9 .956 .000 9 .881 .002
9 .947 .000
9 .499 .172 Kolesterol (pre) &
Kolesterol (post) Pair 1
LDL (pre) & LDL (post) Pair 2
HDL (pre) & HDL (post) Pair 3
Trigiserida (pre) & Trigiserida (post) Pair 4
Ox-LDL (pre) & Ox-LDL (post)
Pair 5
N Correlation Sig.
Paired Samples Test
-14.000 34.406 11.469 -40.447 12.447 -1.221 8 .257
.222 22.703 7.568 -17.229 17.674 .029 8 .977 -1.778 8.969 2.990 -8.672 5.116 -.595 8 .569
-5.333 30.859 10.286 -29.053 18.387 -.518 8 .618
-27.444 70.009 23.336 -81.258 26.369 -1.176 8 .273 Kolesterol (pre)
-Kolesterol (post) Pair 1
LDL (pre) - LDL (post) Pair 2
HDL (pre) - HDL (post) Pair 3
Trigiserida (pre) -Trigiserida (post) Pair 4
Ox-LDL (pre) - Ox-LDL (post)
Pair 5
Mean Std. Deviation
Std. Error
Mean Lower Upper 95% Confidence
Interval of the Difference Paired Differences
NPar Tests (Dosis 80 mg)
T-Test
One-Sample Kolmogorov-Smirnov Test
10 197.60 36.078 .143 .137 -.143 .454 .986
10 199.20 36.411 .142 .142 -.132 .450 .988
10 125.00 33.400 .183 .115 -.183 .579 .891 10 121.20 20.682 .147 .106 -.147 .465 .982 10 48.10 10.408 .154 .154 -.143 .486 .972 10 45.70 10.853 .198 .198 -.162 .627 .827
10 123.60 71.071 .206 .206 -.167 .653 .787
10 146.60 110.368 .356 .356 -.222 1.126 .158
10 144.50 94.151 .199 .199 -.178 .628 .825 10 261.50 54.062 .313 .170 -.313 .989 .282 Kolesterol
(pre) Kolesterol (post) LDL (pre) LDL (post) HDL (pre) HDL (post) Trigiserida (pre) Trigiserida (post) Ox-LDL (pre) Ox-LDL (post)
N Mean Std. Deviation Normal Parametersa,b
Absolute Positive Negative Most Extreme Differences
Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)
Test distribution is Normal. a.
Calculated from data. b.
Paired Samples Statistics
197.60 10 36.078 11.409 199.20 10 36.411 11.514 125.00 10 33.400 10.562 121.20 10 20.682 6.540 48.10 10 10.408 3.291 45.70 10 10.853 3.432 123.60 10 71.071 22.475 146.60 10 110.368 34.902 144.50 10 94.151 29.773 261.50 10 54.062 17.096 Kolesterol (pre)
Kolesterol (post) Pair
1
LDL (pre) LDL (post) Pair
2
HDL (pre) HDL (post) Pair
3
Trigiserida (pre) Trigiserida (post) Pair
4
Ox-LDL (pre) Ox-LDL (post) Pair
5
Mean N Std. Deviation
Std. Error Mean
Paired Samples Correlations
10 .726 .017
10 .787 .007 10 .938 .000
10 .712 .021
10 -.340 .336 Kolesterol (pre) &
Kolesterol (post) Pair 1
LDL (pre) & LDL (post) Pair 2
HDL (pre) & HDL (post) Pair 3
Trigiserida (pre) & Trigiserida (post) Pair 4
Ox-LDL (pre) & Ox-LDL (post)
Pair 5
N Correlation Sig.
Paired Samples Test
-1.600 26.825 8.483 -20.790 17.590 -.189 9 .855
3.800 21.369 6.757 -11.486 19.086 .562 9 .588 2.400 3.777 1.194 -.302 5.102 2.009 9 .075
-23.000 77.866 24.623 -78.702 32.702 -.934 9 .375
-117.000 123.500 39.054 -205.346 -28.654 -2.996 9 .015 Kolesterol (pre)
-Kolesterol (post) Pair 1
LDL (pre) - LDL (post) Pair 2
HDL (pre) - HDL (post) Pair 3
Trigiserida (pre) -Trigiserida (post) Pair 4
Ox-LDL (pre) - Ox-LDL (post)
Pair 5
Mean Std. Deviation Std. Error
Mean Lower Upper 95% Confidence
Interval of the Difference Paired Differences
NPar Tests (Dosis 120 mg)
T-Test
One-Sample Kolmogorov-Smirnov Test
7 214.71 50.255 .229 .179 -.229 .605 .858
7 215.71 31.952 .221 .164 -.221 .585 .883
7 139.57 45.048 .163 .145 -.163 .431 .992 7 138.57 33.040 .162 .162 -.094 .428 .993 7 50.29 6.157 .216 .216 -.155 .572 .899 7 47.71 4.821 .181 .168 -.181 .478 .976
7 125.86 42.807 .248 .162 -.248 .657 .781
7 144.43 47.233 .126 .126 -.096 .334 1.000
7 251.14 58.453 .288 .216 -.288 .763 .606 7 302.43 20.582 .212 .212 -.187 .562 .910 Kolesterol
(pre) Kolesterol (post) LDL (pre) LDL (post) HDL (pre) HDL (post) Trigiserida (pre) Trigiserida (post) Ox-LDL (pre) Ox-LDL (post)
N Mean Std. Deviation Normal Parametersa,b
Absolute Positive Negative Most Extreme Differences
Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)
Test distribution is Normal. a.
Calculated from data. b.
Paired Samples Statistics
214.71 7 50.255 18.995 215.71 7 31.952 12.077 139.57 7 45.048 17.026 138.57 7 33.040 12.488 50.29 7 6.157 2.327 47.71 7 4.821 1.822 125.86 7 42.807 16.180 144.43 7 47.233 17.852 251.14 7 58.453 22.093 302.43 7 20.582 7.779 Kolesterol (pre)
Kolesterol (post) Pair
1
LDL (pre) LDL (post) Pair
2
HDL (pre) HDL (post) Pair
3
Trigiserida (pre) Trigiserida (post) Pair
4
Ox-LDL (pre) Ox-LDL (post) Pair
5
Mean N Std. Deviation
Std. Error Mean
Paired Samples Correlations
7 .870 .011
7 .852 .015 7 .857 .014
7 .878 .009
7 .330 .469 Kolesterol (pre) &
Kolesterol (post) Pair 1
LDL (pre) & LDL (post) Pair 2
HDL (pre) & HDL (post) Pair 3
Trigiserida (pre) & Trigiserida (post) Pair 4
Ox-LDL (pre) & Ox-LDL (post)
Pair 5
N Correlation Sig.
Paired Samples Test
-1.000 27.459 10.379 -26.395 24.395 -.096 6 .926
1.000 24.194 9.144 -21.375 23.375 .109 6 .916 2.571 3.207 1.212 -.395 5.538 2.121 6 .078
-18.571 22.619 8.549 -39.491 2.348 -2.172 6 .073
-51.286 55.190 20.860 -102.328 -.244 -2.459 6 .049 Kolesterol (pre)
-Kolesterol (post) Pair 1
LDL (pre) - LDL (post) Pair 2
HDL (pre) - HDL (post) Pair 3
Trigiserida (pre) -Trigiserida (post) Pair 4
Ox-LDL (pre) - Ox-LDL (post)
Pair 5
Mean Std. Deviation Std. Error
Mean Lower Upper 95% Confidence
Interval of the Difference Paired Differences
NPar Tests (Plasebo)
T-Test
One-Sample Kolmogorov-Smirnov Test
9 187.22 27.833 .199 .199 -.169 .598 .868
9 201.89 26.582 .172 .129 -.172 .517 .952
9 118.44 25.279 .177 .121 -.177 .531 .940 9 127.11 24.700 .237 .237 -.222 .710 .694 9 43.44 5.790 .136 .107 -.136 .408 .996 9 44.78 10.390 .308 .308 -.199 .923 .362
9 125.56 72.236 .236 .236 -.127 .707 .699
9 124.56 68.608 .214 .214 -.197 .642 .805
9 225.44 76.054 .259 .157 -.259 .776 .584 9 283.00 53.796 .196 .153 -.196 .589 .879 Kolesterol
(pre) Kolesterol (post) LDL (pre) LDL (post) HDL (pre) HDL (post) Trigiserida (pre) Trigiserida (post) Ox-LDL (pre) Ox-LDL (post)
N Mean Std. Deviation Normal Parametersa,b
Absolute Positive Negative Most Extreme Differences
Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)
Test distribution is Normal. a.
Calculated from data. b.
Paired Samples Statistics
187.22 9 27.833 9.278 201.89 9 26.582 8.861 118.44 9 25.279 8.426 127.11 9 24.700 8.233 43.44 9 5.790 1.930 44.78 9 10.390 3.463 125.56 9 72.236 24.079 124.56 9 68.608 22.869 225.44 9 76.054 25.351 283.00 9 53.796 17.932 Kolesterol (pre)
Kolesterol (post) Pair
1
LDL (pre) LDL (post) Pair
2
HDL (pre) HDL (post) Pair
3
Trigiserida (pre) Trigiserida (post) Pair
4
Ox-LDL (pre) Ox-LDL (post) Pair
5
Mean N Std. Deviation
Std. Error Mean
Paired Samples Correlations
9 .432 .245
9 .583 .099 9 .733 .025
9 .943 .000
9 -.268 .486 Kolesterol (pre) &
Kolesterol (post) Pair 1
LDL (pre) & LDL (post) Pair 2
HDL (pre) & HDL (post) Pair 3
Trigiserida (pre) & Trigiserida (post) Pair 4
Ox-LDL (pre) & Ox-LDL (post)
Pair 5
N Correlation Sig.
Paired Samples Test
-14.667 29.009 9.670 -36.965 7.631 -1.517 8 .168
-8.667 22.814 7.605 -26.203 8.870 -1.140 8 .287 -1.333 7.297 2.432 -6.943 4.276 -.548 8 .599
1.000 24.005 8.002 -17.452 19.452 .125 8 .904
-57.556 104.261 34.754 -137.697 22.586 -1.656 8 .136 Kolesterol (pre)
-Kolesterol (post) Pair 1
LDL (pre) - LDL (post) Pair 2
HDL (pre) - HDL (post) Pair 3
Trigiserida (pre) -Trigiserida (post) Pair 4
Ox-LDL (pre) - Ox-LDL (post)
Pair 5
Mean Std. Deviation Std. Error
Mean Lower Upper 95% Confidence
Interval of the Difference Paired Differences
