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324

ياﺮﺑ ﮏﯿﺘﻧژ ﮏﻧﺎﺑ ﻞﯿﮑﺸﺗ ﯽﺳرﺮﺑ

يﺎﻫ ﯽﮑﯿﺘﻧژ و

ﯽﭘا ﯽﮑﯿﺘﻧژ

لﻼﺘﺧا رد يﺎﻫ

ﯽﮑﺷﺰﭙﻧاور

يﺮﯾﺪﻗ ﺪﻤﺤﻣ ﺮﺘﮐد

،

1

ﻪﺣﻮﻧ ﻢﻨﺒﺷﺮﺘﮐد

2اﺮﺳ يﻮﻔﻄﺼﻣ ﺪﯿﻤﺣ ﺮﺘﮐد ، ﯽﮑﻠﻤﻟاﺪﺒﻋ

ﺎﻬﯿﻧﺎﺧﺪﻤﺣا ﺎﺿرﺪﯿﻤﺣ ﺮﺘﮐد ،2

نﺎﺑﺎﺗ نﺎﮔﮋﻣ ، 3

4

The Establishment of Iranian DNA Bank for Genetic and Epigenetic Studies in Psychiatric Disorders

Mohammad Ghadiri *, Shabnam Nohesara ^a, Hamid Mostafavi Abdolmaleky ^a, Hamidreza Ahmadkhaniha ^b, Mozhgan Taban ^c

هﺪﯿﮑﭼ رد

:فﺪــﻫ

ﺮﺘﺸﯿﺑ

يﺎﻫرﻮــﺸﮐ ﮏــﻧﺎﺑ نﺎــﻬﺟ ﻪﺘﻓﺮــﺸﯿﭘ

ﺪﯿــﺳا ،ﯽﺘﻓﺎــﺑ يﺎــﻫ

ﯽﺴﮐﻮﺋد ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر و

ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﺪﯿﺳا

ياﺮـﺑ

ﯽـﺳرﺮﺑ

يﺎـﻫ

ﯽـﮑﯿﺘﻧژ

لﻼﺘﺧا عاﻮﻧا رد يﺎﻫ

ﮑﺷﺰﭘ ﯽ ﻪﺘﺧﺎﺳ ﺑ ﺎﺗ هﺪﺷ ﺎ هژوﺮﭘ ﺐﯾﻮﺼﺗ

ﯽـﺸﻫوﮋﭘ يا

ﻪﻧﻮﻤﻧ ﻪﺑ ﺎﻫ ناﺮﮕﺸﻫوﮋﭘ راﺬﮔاو

ددﺮﮔ و زا ﻦﺘﻓررﺪـﻫ

و ﺖـﻗو ﻪـﻨﯾﺰﻫ

ياﺮـﺑ

هدﺎﻣآ هژوﺮﭘ ﺮﻫ يزﺎﺳ

ﮏـﻧﺎﺑ ﻦـﯾا رد

.

دﻮـﺷ يﺮﯿﮔﻮﻠﺟ

ﺮـﺑ نارﺎـﻤﯿﺑ ﺎـﻫ

ﻪـﯾﺎﭘ

ﻦﯿــﺑ ﯽــﺼﯿﺨﺸﺗ يﺎــﻫرﺎﯿﻌﻣ ﻪــﺑ ﯽــﻠﻠﻤﻟا

ﯽــﻣ ﯽﺑﺎــﯾزرا ﺖــﻗد ﻮــﺷ

ﺪﻧ ا

.

ور ﻦــﯾا ز

ﻊﻤﺟ يﺪﻨﺑ ﻪﺘﻓﺎﯾ ﺎﻫ ﻖﻓاﻮﺗ زا ﻪﺑ ﺖﺒﺴﻧ يﺮﺗﻻﺎﺑ يﺮﯾﺬﭘ ﺶﻫوﮋـﭘ

يﺎـﻫ

هﺪـﻨﮐاﺮﭘ

و هدﻮﺑ رادرﻮﺧﺮﺑ مﺎﺠﻧا نﺎﮑﻣا

ﯽـﺳرﺮﺑ يﺎـﻫ

ﻪـﺘﻓﺎﯾ يور ﺮـﺑ ﻞـﯿﻠﺤﺗاﺮﻓ

يﺎـﻫ

ﺑﻪ هﺪﻣآ ﺖﺳد ﺶﯾﺎﻣزآ رد

يﺎﻫ نﻮﮔﺎـﻧﻮﮔ

ﯽـﻣ ﻢﻫاﺮـﻓ دﻮـﺷ

شور. :

ياﺮـﺑ

ﺧﺎﺳ ﯽﮑﻧﺎﺑ ﻦﯿﻨﭼ ﺖ لﻼﺘﺧا ياﺮﺑ

يﺎﻫ

،ﯽـﻧاﺮﯾا ﻪﻌﻣﺎﺟ رد ﯽﮑﺷﺰﭙﻧاور

ﺲـﭘ

ﻦﺷور زا فﺪﻫ يزﺎﺳ ﺎﻫ

و ﻦﺘﻓﺮﮔ ﺖﯾﺎﺿر نارﺎﻤﯿﺑ زا ﻪﻣﺎﻧ مﺎـﺠﻧا و

ﻪﺒﺣﺎـﺼﻣ

لﻼﺘﺧا ياﺮﺑ ﻪﺘﻓﺎﯾرﺎﺘﺧﺎﺳ ﯽﻨﯿﻟﺎﺑ

رﻮـﺤﻣ يﺎـﻫ

ﮏـﯾ

DSM-IV SCID-I)

،

(

300

ﯽــﺴﮐﻮﺋد ﺪﯿــﺳا نژاروا ﺖ ــﯿﮐ ﮏــﻤﮐ ﻪ

ــﺑ ﯽــﻗاﺰﺑ ﻪــﻧﻮﻤﻧ ﮏــﯿﺌﻠﮐﻮﻧﻮﺒﯾر

آدﺮﮔ و هﺪﺷ يرو داد

ه يﺎـﻫ ـﯿﻌﻤﺟ ﺖ

،ﯽﺘﺧﺎﻨـﺷ

ﻪﻘﺑﺎـﺳ ﮔداﻮﻧﺎـﺧ

،ﯽ نﺎـﻣز

لﻮﻃ و عوﺮﺷ

،يرﺎﻤﯿﺑ و ﯽﻓﺮﺼﻣ يﺎﻫوراد

ﺎـﻬﻧآ ﺪـﻨﻧﺎﻣ

نارﺎـﻤﯿﺑ هﺪـﻧوﺮﭘ رد

ﺎﺑ طﺎﺒﺗرا نﺎﮑﻣا و ﺪﯾدﺮﮔ ﺖﺒﺛ آ

ﺎﻬﻧ ياﺮﺑ

ﺮﯿـﺳ ﯽـﺳرﺮﺑ و تﺎـﻋﻼﻃا ﻞﯿﻤﮑﺗ

.

ﺪﺷ ﻢﻫاﺮﻓ يرﺎﻤﯿﺑ

ﻪـﺘﻓﺎﯾ

ﺎـﻫ :

ﺪﯿـﺳا جاﺮﺨﺘـﺳا ياﺮـﺑ ﯽـﻗاﺰﺑ ﻪـﻧﻮﻤﻧ ﮏـﻧﺎﺑ

ﯽﺴﮐﻮﺋد زا ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر

300

ﻞﻣﺎﺷ ﯽﮑﺷﺰﭙﻧاور رﺎﻤﯿﺑ

لﻼﺘـﺧا

،ﯽـﺒﻄﻗ ود

،ﺎﯿﻧﺮﻓوﺰﯿﮑــﺳا لﻼﺘــﺧا

اﻓ ــﺳاﻮﺳو لﻼﺘــﺧا ،ﯽــﺳﺎﺳا ﯽﮔدﺮــﺴ ﯽ

-

ا ــﺒﺟ ﺎ ير

و نﺎﺘــﺳرﺎﻤﯿﺑ نارﺎــﻤﯿﺑ نﺎــﯿﻣ زا ﻪــﺟﻮﺗ دﻮــﺒﻤﮐ ﺎــﺑ ﯽﻟﺎــﻌﻓ ﺶﯿــﺑ لﻼﺘــﺧا يﺎــﻫ

ﯽﮑﺷﺰﭙﻧاور

، ﻢﻫ ﻦﯿﻨﭼ

لﻼﺘـﺧا رﺎـﭼد نارﺎﻤﯿﺑ لوا ﻪﺟرد نﺎﮕﺘﺴﺑ زا ﻦﺗ ﯽﺳ

و ﺎﯿﻧﺮﻓوﺰﯿﮑﺳا و ﯽﺒﻄﻗود

100

هوﺮـﮔ ود ﺎـﺑ ﻪـﮐ هاﻮـﮔ هوﺮـﮔ ناﻮـﻨﻋ ﻪﺑ ﺮﻔﻧ

ﻦﯿﺸﯿﭘ ﺎﺘﻤﻫ هﺪﺷ يزﺎﺳ ﺑ ﺪﻧدﻮ يروآدﺮﮔ ﺪﺷ

ﻪﺠﯿﺘﻧ. يﺮﯿﮔ :

اﺪـﻫا نﺎﮑﻣا

ء ﻦ ﯿﺑ ﺎﯾ ﯽﻠﻣ يﺎﻫ ﯽﺳرﺮﺑ ياﺮﺑ ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﯽﺴﮐﻮﺋد ﺪﯿﺳا يﺎﻫ ﻪﻧﻮﻤﻧ ﯽﻠﻠﻤﻟا

هﺪﺷ ﻢﻫاﺮﻓ ﺖﺳا

.

:هژاوﺪﯿﻠﮐ ﯽﭘا ؛ﮏﯿﺘﻧژ ﮏﻧﺎﺑ

ﯽﮑﺷﺰﭙﻧاور تﻻﻼﺘﺧا ؛ﮏﯿﺘﻧژ

:ﻪﻟﺎﻘﻣ ﺖﻓﺎﯾرد] 19

/2 / 1389 :ﻪﻟﺎﻘﻣ شﺮﯾﺬﭘ ؛ 15

/9 / 1389 [ Abstract

Objectives: In most advanced countries, there are tissue, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) banks which have been made to provide samples for researchers in order to speed up genetic studies in different medical disorders. This may save time and materials in comparison to self-governing projects that usually spend months to collect samples independently.

In these banks patients are cautiously diagnosed based on international diagnostic criteria. Thus, the results are more reliable than scattered studies and meta-analysis can be done with the data generated in different laboratories using the same samples. Method: For the establishment of a DNA bank for psychiatric disorders in Iran, after clarifying the aims and signing the consent forms, 300 saliva samples were collected using Oragene DNA Kit from the patients diagnosed based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I).

Related data to demographics, family history, date of disorder onset, duration of disorder, drugs in use and other variables were compiled and opportunity for future contacts was set to gather more information including the course of disorders. Results: A saliva bank for DNA extraction of 300 psychiatric patients suffering from schizophrenia, bipolar disorder, major depressive disorder, obsessive-compulsive disorder and attention deficit hyperactivity disorder, 30 ones relatives as well as 75 matched healthy control subjects for genetic and epigenetic studies was established. Conclusion: The opportunity for donation of DNA samples collected from Iranian psychiatric patients has been provided to be used in hundreds of national and international genetic studies.

Key words: genetic bank; epigenetic; psychiatric disorders [Received: 9 May 2010; Accepted: 6 December 2010]

_______________________________________

.ناور ﺖﺷاﺪﻬﺑ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ ،ناﺮﻬﺗ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد رﺎﯾدﺎﺘﺳا ،ﮏﺷﺰﭙﻧاور1

ﺘﻣﻮﻠﯿﮐ،ناﺮﻬﺗ 7 ﺮ

،جﺮﮐ صﻮﺼﺨﻣ هدﺎﺟ

،نﺎﮔدازآ يﺪﻨﺑﺮﻤﮐ ياﺪﺘﺑا ﯽﮑـﺷﺰﭙﻧاور نﺎﺘـﺳرﺎﻤﯿﺑ

:رﺎﮕﻧرود .ناﺮﯾا 44503401

- (لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ)021 E-mail: [email protected]

2؛ ،ﮏﺷﺰﭙﻧاور ،ناﺮـﻬﺗ ﯽﮑـﺷﺰﭘ مﻮـﻠﻋ هﺎﮕﺸﻧاد رﺎﯾدﺎﺘﺳا

تﺎـﻘﯿﻘﺤﺗ ﺰـﮐﺮﻣ

،ناور ﺖﺷاﺪﻬﺑ ناور ﻮﺘﯿﺘﺴﻧا

؛ناﺮﻬﺗ ﯽﮑﺷﺰﭘ ،ﮏﺷﺰﭙﻧاور3

،ناﺮـﻬﺗ ﯽﮑـﺷﺰﭘ مﻮـﻠﻋ هﺎﮕـﺸﻧاد رﺎﯿـﺸﻧاد ،ناور ﺖـﺷاﺪﻬﺑ تﺎـﻘﯿﻘﺤﺗ ﺰـﮐﺮﻣ

ناور ﻮﺘﯿﺘـﺴﻧا ؛ناﺮـﻬﺗ ﯽﮑـﺷﺰﭘ سﺎﻨـﺷرﺎﮐ4

،ﯽﻨﯿﻟﺎﺑ ﯽﺳﺎﻨﺸﻧاور ،ناور ﺖﺷاﺪﻬﺑ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ

.ناﺮﻬﺗ ﯽﮑﺷﺰﭙﻧاور ﻮﺘﯿﺘﺴﻧا

* Corresponding author: Psychiatrist, Assistant Prof. of Tehran University of Medical Sciences, Mental Health Research Center, Tehran, Km 7 special road, Karaj, Azadegan Highway, Iran Hospital of Psychiatry, Tehran, Iran, IR. Fax: +9821-44503401. E- mail: [email protected], ^a Psychiatrist, Assistant Prof. of Tehran University of Medical Sciences, Mental Health Research Center, Tehran Psychiatric Institute, ^b Psychiatrist, Associate Prof. of Tehran University of Medical Sciences, Mental Health Research Center, Tehran Psychiatric Institute, ^C BA. in Clinical Psychology, Mental Health Research center, Tehran Psychiatric Institute.

Iranian Journal of Psychiatry and Clinical Psychology, Vol. 17, No. 4, Winter 2012, 324 - 331

ﻪﻠﺠﻣ هرﺎﻤﺷ ،ﻢﻫﺪﻔﻫ لﺎﺳ ،ناﺮﯾا ﯽﻨﯿﻟﺎﺑ ﯽﺳﺎﻨﺸﻧاور و ﯽﮑﺷﺰﭙﻧاور 4

نﺎﺘﺴﻣز ، 1390 ، 331 - 324

ﯽﺸﻫوﮋﭘ ﻪﻟﺎﻘﻣ ﻞﯿﺻا

Original Article

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نارﺎﮑﻤﻫ و يﺮﯾﺪﻗ ﺪﻤﺤﻣ

325

لﺎﺳﻢﻫﺪﻔﻫرﺎﻤﺷ /ه 4 /نﺎﺘﺴﻣز1390 Vol. 17 / No. 4 / Winter 2012

ﻪﻣﺪﻘﻣ هزوﺮﻣا ﺮﺘﺸﯿﺑ رد يﺎﻫرﻮﺸﮐ نﺎـﻬﺟ ﻪﺘﻓﺮﺸﯿﭘ

ﺎـﺑ ﻪـﯾﺎﭘ يراﺬـﮔ

ﮏــﻧﺎﺑ ﮏــﯿﺘﻧژ ﺎــﯾ ﯽﺘﻓﺎــﺑ يﺎــﻫ نﺎﺘــﺳرﺎﻤﯿﺑ)

ﮏــﻣ ــﻟﯿ

1

ﻦ ، 2003 (

ﻪﺘﺴﻧاﻮﺗ ﻪﺑ ﺪﻧا ﺶﻫوﮋﭘ يﺎﻫ ﮑﺷﺰﭘ .ﺪﻨـﺸﺨﺑ ﺖـﯿﻌﻣﺎﺟ و ﺖﻋﺮﺳ ﯽ

ﮏـﻧﺎﺑ ﻦﯾا ﻞﯿﮑﺸﺗ رد ﯽﻠﮐ ﺖﺳﺎﯿﺳ

ﻦـﯾا ﯽـﮑﯿﺘﻧژ و ﯽﺘﻓﺎـﺑ يﺎـﻫ

ا ﻪﮐ ﺖﺳ ﺖﺴﺨﻧ ﻪﺑ نارﺎﻤﯿﺑ ﺖﻗد هﺎﮔﺪﯾد زا را ﯽـﺼﯿﺨﺸﺗ

ﯽﺑﺎـﯾز

ﺪﻧﻮـﺷ و ــﻤﻫ ﻪ هداد يﺎـﻫ

ﻦـﺳ ﺪــﻨﻧﺎﻣ ﺖـﯿﻤﻫا ﺎــﺑ

، ﺲﻨــﺟ

، ﻪﻘﺑﺎــﺳ

ﺧ ﺎ ﮔداﻮﻧ ﯽ

، نﺎﻣز يرﺎﻤﯿﺑ لﻮﻃ و عوﺮﺷ و

رد ﯽﻓﺮﺼﻣ يﺎﻫوراد

ﺎﻬﻧآ هﺪﻧوﺮﭘ ﻪﺘﺷﻮﻧ

دﻮﺷ . نوﺰﻓا

،نآﺮﺑ هار و ﯽﻧﺎﺸﻧ يﺎﻫ

ﺎـﺑ طﺎﺒﺗرا

ﺎﻬﻧآ ياﺮـﺑ يرﺎـﻤﯿﺑ ﺮﯿـﺳ ﯽـﺳرﺮﺑ و تﺎـﻋﻼﻃا ﻞـﯿﻤﮑﺗ هﺪﯿـﺳﺮﭘ

ﯽـــﻣ ﯽـــﻗاﺰﺑ ﺎـــﯾ ﯽﻧﻮـــﺧ ﻪـــﻧﻮﻤﻧ ﺲﭙـــﺳ و دﻮـــﺷ اراد

ي ﺪﯿـــﺳا

ﯽﺴﮐﻮﺋد ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﻪـﮐ ﯽﺘـﺳﻮﭘ ﻪﻌﻄﻗ ﯽﻫﺎﮔو ﺎﻬﻧآ

2

ﺲـﭘ زا

ـﺑ ﻪﻨﺘﺧ ﻪ ﯽـﻣ ﺎـﺟ ﺪـﻧﺎﻣ

، ياﺮـﺑ ﯽـﺳرﺮﺑ يﺎـﻫ آﯾ هﺪـﻨ آدﺮـﮔ و يرو

ﯽﻣ يراﺪﻬﮕﻧ

يدﺮـﮑﯾور ﻦﯿـﻨﭼ رد .دﻮـﺷ ﻪـﻧﻮﻤﻧ

ﯽﻧﻮـﺧ يﺎـﻫ -

رﺎﻤﯿﺑ ﺮﻫ ﯽﻗاﺰﺑ ﯽﻣ ار

ناﻮﺗ ﺎﻫﺪﺻ ياﺮﺑ ﺶﻫوﮋﭘ

ﺎـﯾ ﮏﯾژﻮﻟوﺮﺳ

ﯽﮑﯿﺘﻧژ ﻪﺑ ﺘﻓﺎﯾ زا و دﺮﺑرﺎﮐ ﻪ

ﻪﺑ يﺎﻫ هﺪﻣآ ﺖﺳد هﺎﮕﺸﯾﺎﻣزآ رد

ﺎـﻫ

و هوﺮــﮔ يﺎــﻫ ــﺸﻫوﮋﭘ ﯽ نﻮﮔﺎــﻧﻮﮔ ﺰــﯿﻧ

هﺮــﻬﺑ ﺮﮔ ﺎــﺘﯿﻧآ) ﺖــﻓ و

3

نارﺎﮑﻤﻫ ، 2008 سﻮﯾرﻮﺗرﺎﺳ ؛ ،

4

2008 ( . ﻢﻫ ﺎـﺑ ﻦﯿﻨﭼ ﺐﯾﻮـﺼﺗ

ﻪﻧﻮﻤﻧ ،ﯽﻘﯿﻘﺤﺗ هژوﺮﭘ ﺮﻫ ﻪـﺑ ءاﺪﻫا ياﺮﺑ ﺎﻫ

ناﺮﮕـﺸﻫوﮋﭘ هدﺎـﻣآ

زا ﻪﮐ هدﻮﺑ ﻪﻨﯾﺰﻫ

ﺎﻫ هدﺎﻣآ ياﺮﺑ ﻞﻘﺘـﺴﻣ هژوﺮﭘ ﺮﻫ يزﺎﺳ

ـﻫاﻮﺧ ﺪ

ﺖﺳﺎﮐ . ﺎﺠﻧآ زا ﻪﮐ اﻣ ﺮﺑ هزوﺮ ﯽﺳر يﺎﻫ ﮑﯿﺘﻧژ ﯽ زا ﺖﯾﻮﻟوا يﺎـﻫ

ﻪﺑ ﯽﺸﻫوﮋﭘ ﯽﻣ رﺎﻤﺷ

ﺪﻧور ﯽﺘﯿﻠﻣﺪﻨﭼ ﺰﮐاﺮﻣ و ﯽﺳرﺮﺑ ياﺮﺑ

يﺎـﻫ

ﯽﮑﯿﺘﻧژ ﻪﯾﺎﭘ ﺪـﺷ يراﺬﮔ

ﻞﮑـﺷ لﺎـﺣرد ﺎـﯾ ه ﮔ

ـﯿ ﺮ ي ﯽـﻣ ـﺷﺎﺑ ﻨ ،ﺪ

ﯽﻣ ﯽﮑﻧﺎﺑ ﻦﯿﻨﭼ ﻞﯿﮑﺸﺗ ﻪﺑ ﺪﻧاﻮﺗ

ﯽﺳرﺮﺑ يﺎﻫ ﻦﯿﺑ كﺮﺘﺸﻣ ﻠﻤﻟا

ﻠ ﯽ

.ﺪﻣﺎﺠﻧﺎﯿﺑ ﺰﯿﻧ نوﺰـﻓا

ﺎﺠﻧآ زا نآﺮـﺑ

ﺮﺑ يرﺎـﻤﯿﺑ ﺺﯿﺨـﺸﺗ ﻪـﮐ ﻪـﯾﺎﭘ

ﺸﺗ يﺎﻫرﺎﯿﻌﻣ ﻦﯿﺑ ﯽﺼﯿﺨ

ﻠﻤﻟا ﻠ ﯽﻣ مﺎﺠﻧا يﺮﺘﺸﯿﺑ ﺖﻗد ﺎﺑ و ﯽ ﻮﺷ

،د

ﻖﻓاﻮﺗ ﻊﻤﺟ رد يﺮﯾﺬﭘ ﺞﯾﺎﺘﻧ يﺪﻨﺑ

، زا ﺮﺗﻻﺎﺑ رﺎﯿﺴﺑ ﺶﻫوﮋـﭘ

يﺎـﻫ

ـﺑ .دﻮﺑ ﺪﻫاﻮﺧ هﺪﻨﮐاﺮﭘ ﻪ

ﮏـﻧﺎﺑ دﺎـﺠﯾا ﺮـﯿﺧا ﻪـﻫد رد هﮋـﯾو يﺎـﻫ

ﻪﺘﻓﺮﯾﺬﭘ ﺖﺳﺎﯿﺳ ﮏﯿﺘﻧژ و ءﺎﻀﻋا ،نﻮﺧ هﺪﺷ

يا ﺑﻪ ﯽـﻣ رﺎﻤﺷ دور

و ﯽﻧﺎﻣرد يﺎﻫدﺎﻬﻧ يﻮﺳ زا -

ﺸﻫوﮋﭘ ﯽﻧﺎـﻬﺟ ﯽ ـﺸﻧاد و

هﺎﮕ يﺎـﻫ

ﻢــﻫ ﺮــﺒﺘﻌﻣ و كود ،دراورﺎـــﻫ نﻮــﭼ

آ درﻮﻔــﺴﮐ فﺪـــﻫ ﺎــﺑ

ﺖﻋﺮﺳ ﻪـﺑ نﺪﯿﺸﺨﺑ ﯽـﺳرﺮﺑ

يﺎـﻫ درﻮـﻣ ﯽـﮑﯿﺘﻧژﺮﯿﻏ و ﯽـﮑﯿﺘﻧژ

ﯽﻧﺎﺒﯿﺘــﺸﭘ ﺖــﺳا ﻪــﺘﻓﺮﮔراﺮﻗ

) نﺎﺘــﺳرﺎﻤﯿﺑ ،نﺎــﺌﻟ ﮏــﻣ

2003 .(

ﺖﺴﺟ و هﺎـﮕﯾﺎﭘ رد ﻮﺟ دﺮﺑرﺎـﮐ ﺎـﺑ ﮏـﯿﻧوﺮﺘﮑﻟا ﯽﺗﺎـﻋﻼﻃا يﺎـﻫ

هژاوﺪﯿﻠﮐ ﮏـﻧﺎﺑ و ﯽﺘﻓﺎـﺑ ﮏﻧﺎﺑ ،ﮏﯿﺘﻧژ ﮏﻧﺎﺑ نﻮﭼ ﯽﯾﺎﻫ ﺪﯿـﺳا

ﺋد ﯽﺴﮐﻮ ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﯽﻣ نﺎﺸﻧ ،

ﺪﻫد نآ ﺎﺑ هزوﺮﻣا ﻪﮐ يرﺎﯿـﺴﺑ

زا ﮏــﻧﺎﺑ ﻦﯿــﻨﭼ ياراد ﻪﺘﻓﺮــﺸﯿﭘ يﺎﻫرﻮــﺸﮐ ﺎــﻫ

ﯾ ﯽــﻣ ﯽ ﺪﻨــﺷﺎﺑ

،

ﺘﻣ ﺄ رد ﻪﻧﺎﻔــﺳ ــﻫ

ﯿ ﭻ يﺎﻫرﻮــﺸﮐ زا ﮏــﯾ ،ﻪــﻧﺎﯿﻣروﺎﺧ

و ﺎــﺑ دﻮــﺟ ﺶﻫوﮋﭘ

يﺎﻫ هﺪﺸﻧ شراﺰﮔ ﯽﮑﻧﺎﺑ ﻦﯿﻨﭼ دﻮﺟو ﯽﮑﯿﺘﻧژ هﺪﻨﮐاﺮﭘ

ﺖﺳا ﻢﻫ

.

ﺖـﺴﺟ ﻦﯿﻨﭼ و

ﺖـﺳا نآ يﺎـﯾﻮﮔ هﺪـﺷدﺎﯾ يﻮـﺟ ﻪـﮐ

ﯽﻟﺎﺣرد ﻢﺠﺣ ﻪﮐ يﺎﻫرﺎﺘﺷﻮﻧ زا ﯽﯾﻻﺎﺑ

ار يزوﺮﻣا ﺶﻫوﮋﭘ

يﺎﻫ

ﮑﺸﺗ ﯽﮑﯿﺘﻧژ ﯿ

ﯽﻣ ﻞ ﻫد ﻨ ﺪ ، نﺪـﻤﺗ زﺎﺘـﺸﯿﭘ ﻪـﮐ ﻪـﻧﺎﯿﻣروﺎﺧ ﻪـﻘﻄﻨﻣ

ﺑ ﺖﺳا هدﻮﺑ يﺮﺸﺑ ﻪ

ﻦـﯾا رﻮـﮐ ﻪﻄﻘﻧ ناﻮﻨﻋ ﯽـﺳرﺮﺑ

ﺎـﻫ

رﺎﻤـﺷ ﻪـﺑ

ﯽﻣ ر ﺑ ناﺮﯾا .دو ﻪ

هﺪﻧﺮﯿﮔﺮﺑرد ﻪﮐ يرﻮﺸﮐ ناﻮﻨﻋ ﻫ

ﻤ ﻪ ﻦـﯾا ماﻮـﻗا

ﺖﺳا ﯽﯾﺎﯿﻓاﺮﻐﺟ ﻪﻘﻄﻨﻣ ،

ﯽﻣ ـﺑ ﺪﻧاﻮﺗ ﻪ

ا يرﻮـﺸﮐ ناﻮـﻨﻋ ﯽﯾﺎﻨﺜﺘـﺳ

،

ﺰــﯿﻧ ﻪــﻘﻄﻨﻣ ﻦــﯾا ﯽــﮑﯿﺘﻧژ هﺪــﻨﯾﺎﻤﻧ ﻪــﺑ

رﺎﻤــﺷ ر ا .دو ﻦــﯾا ز ور ﺎــﺑ

ﻪﯾﺎﭘ يراﺬﮔ د ﯽﮑﯿﺘﻧژ ﮏﻧﺎﺑ ﮏﯾ ﺖﺳ

ﻢـﮐ ياﺮـﺑ ﺶﻫوﮋـﭘ يﺎـﻫ

ﯽـﻣ ناﺮﯾا ،ﯽﮑﺷﺰﭙﻧاور رد ﯽﮑﯿﺘﻧژ ﻦﯿـﻨﭼ زﺎﺘـﺸﯿﭘ ﺎـﻬﻨﺗ ﻪـﻧ ﺪـﻧاﻮﺗ

لﻮﺤﺗ ﯽﺸﻫوﮋﭘ رد ﻪﻧﺎﺸﯾﺪﻧارود رﻮﺸﮐ

ﻪـﮑﻠﺑ ،ﺪـﺷﺎﺑ ﻪـﺘﻓﺎﯾ

يﺎـﻫ

ﻞﺑﺎﻗ ﯽﻠﻤﻋ ﻞﺑﺎﻗ و دﺎﻨﺘﺳا

ياﺮﺑ ﻢﯿﻤﻌﺗ .ﺪـﻫد ﻪـﺋارا ﻪـﻧﺎﯿﻣروﺎﺧ ﻞﮐ

ﻪﺑ ﺮﮕﯾد نﺎﯿﺑ

، ﯽﻤﻠﻋ ﺖﯿﻓﺮﻇ و

ﯽﻟﺎﻣ ﯽﺘﯿﻌﻤﺟ ﺖﻓﺎﺑ ﺎﯾ يﺎﻫرﻮـﺸﮐ

ﻤﻫ ﺴ ﺎ ﻪﯾ ﺑ ﺰﯿﻧ ﻪ ﻪﻧﻮﮔ ﻪﮐ ﺖﺳا يا ﺶﯿﭘ

ﯽﻨﯿﺑ ﯽﻤﻧ ـﺷ رﺎـﺑ ﺪـﻨﻧاﻮﺘﺑ دﻮ

ﺑ ار ﯽﺘﯿﻟﻮﺌﺴﻣ ﻦﯿﻨﭼ ﻪ

.ﺪﻨﺸﮐ شود

ﺖــﯾﺎﻤﺣ زا ﻪﺘــﺷﺬﮔ ﺶﻫوﮋــﭘ

يﺎــﻫ ﯽــﮑﯿﺘﻧژ رﻮــﺸﮐ و ي

ﻪــﻘﻄﻨﻣ

،يا ﺪﯿــﺳا ﯽــﺴﮐﻮﺋد ﮏــﯿﺌﻠﮐﻮﻧﻮﺒﯾر

اﺪــﺟ ﻦــﯾا زا هﺪــﺷ

ﻪﻧﻮﻤﻧ ﯽﻣ ار ﯽﻧﻮﺧ يﺎﻫ رد ناﻮﺗ

ﺮـﺑاﺮﺑ رﺎـﯿﺘﺧا رد ﻪـﺟو ﺖـﻓﺎﯾرد

ﺮﯾﺎــﺳ ناﺮﮕــﺸﻫوﮋﭘ ﻪــﻘﻄﻨﻣ

ﻧ ــﯿ ﺰ يزرا ﺪــﻣآرد ﻪــﮐ داد راﺮــﻗ

ﻢﺸﭼ يﺮـﯿﮔ ياﺮـﺑ

ﯽـﺳرﺮﺑ مﺎـﺠﻧا يﺎـﻫ

ﻪﺘﻓﺮـﺸﯿﭘ رﻮـﺸﮐ ﻢﻫاﺮـﻓ

.ﺖﺧﺎﺳ ﺪﻫاﻮﺧ ﻢﻫ

نﻮـﻨﮐا ﻪـﻨﯾﺰﻫ ﯽﻧﺎـﻬﺟ ياﺮـﺑ ﻪـﮐ ﻪـﻧﻮﻤﻧ ﺮـﻫ

ﺑ ــﺧﺮ ﮏــﻧﺎﺑ ﯽ ﺎــﻫ ﺪــﻨﻧﺎﻣ ﺖــﺷاﺪﻬﺑ ﯽــﻠﻣ ﻮﺘﯿﺘــﺴﻧا )

5NIH

ﺮــﺑ ( يا

ﯽﻣ ﺖﻓﺎﯾرد ﻪﺑﺎﺸﻣ تﺎﻣﺪﺧ ﺪﻨﻨﮐ

، ﺰﻧ د ﻪﺑ ﮏﯾ ﮏﯾ ﺖﺳا رﻻد ﺪﺻ

) ﻮﺘﯿﺘﺴﻧا ﻞﯾرﻮﮐ ،

6

2009 ( ﯽﻟﺎﺣ رد ، ﻪﮐ ﺪﯿﺳا ﯽـﺴﮐﻮﺋد ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر

ﻪﺘﻓﺮﮔﺮﺑ زا هﺪﺷ ﯽﻠﯿﻣ ﺞﻨﭘ ﺮﺘﯿﻟ هد ياﺮﺑ ﻪﻧﻮﻤﻧ ﺮﻫ قاﺰﺑ ﺎﯾ نﻮﺧ و ﺎﻫ

ﺎﻫﺪﺻ ﯽﻫﺎﮔ ﯽﺳرﺮﺑ

ﯽﮑﯿﺘﻧژ ﯽﻣ ﺖﯾﺎﻔﮐ ﺪـﻨﮐ

) ﻮﻟﺎـﮔ ،

7

2003 .(

ﻪﮐﺎﺠﻧآزا جاﺮﺨﺘﺳا ﻪﻨﯾﺰﻫ

ﺪﯿﺳا د ﯽـﺴﮐﻮﺋ رﺎﯿـﺴﺑ ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر

ﺪﻣآرد ،ﺖﺳا كﺪﻧا ﻪﺑ

هﺪﻣآ ﺖﺳد ﻪﻧﻮﻤﻧ زا

يﺎﻫ ﻓ ﺳﺮ ﺘﺎ هد ار هﺪﺷ

ﯽﻣ ياﺮﺑ ناﻮﺗ ﺶﻫوﮋﭘ

يﺎﻫ ﺪﻫ ﺮﮕﯾد ﻪﯾ نﺎﻨﭼ .دﻮﻤﻧ ﻪـﻧﻮﻤﻧ ﻪﭼ

ﺎـﻫ

ﺖﯾﺎﻤﺣ بﺬﺟ ﻪﻨﯿﻣز ،دﻮﺷ لﺎﺳرا ﻪﺟو ﺖﻓﺎﯾرد نوﺪﺑ ﯽﻟﺎﻣ يﺎﻫ

ﻣ زا ﺆ تﺎﺴﺳ ﺸﻫوﮋﭘ ﻦﯿﺑ ﯽ ﻤﻟا ﻠ .ﺪﺷ ﺪﻫاﻮﺧ ﻢﻫاﺮﻓ ﯽﻠ ﻦﯾا زا

ور ﺎـﺑ

ﻮﻣ ﻪﺑ ﻪﺟﻮﺗ درا

دﺎﯾ هﺪﺷ

، ﻪﯾﺎﭘ يراﺬﮔ ﻪﻧ ﯽﮑﯿﺘﻧژ ﮏﻧﺎﺑ ﻦﯿﻨﭼ ﺎـﻬﻨﺗ

ﺖـﺳا ﻪﺘـﺴﯾﺎﺷ ﻪـﮑﻠﺑ ﺖـﺳا يروﺮـﺿ ناﺮﯾا رد ﻢـﻫ

ﺮﯾﺎـﺳ نﻮـﭼ

ﺎﻫرﻮﺸﮐ يرﺎـﻤﯿﺑ ﺮﯾﺎﺳ ياﺮﺑ ﯽﮑﻧﺎﺑ ﻦﯿﻨﭼ ﻞﯿﮑﺸﺗ يﺎـﻫ

ﮑـﺷﺰﭘ ﯽ

دﻮﺷ ﻪﺘﻓﺮﮔﺮﻈﻧرد ﺰﯿﻧ .

1

_______________________________________

1- McLean Hospital 2- deoxyribonucleic acid

3- Anitha 4- Sartorius

5- National Institute of Health

6- Coriell Institute 7- Galloux

Downloaded from ijpcp.iums.ac.ir at 12:01 CEST on Wednesday October 8th 2014

(3)

ﮏﯿﺘﻧژ ﮏﻧﺎﺑ ﻞﯿﮑﺸﺗ ياﺮﺑ

لﻼﺘﺧا يﺎﻫ ﯽﮑﺷﺰﭙﻧاور

326

لﺎﺳﻢﻫﺪﻔﻫ/رﺎﻤﺷه 4 /نﺎﺘﺴﻣز1390

Vol. 17 / No. 4 / Winter 2012

رد ﯽﺧﺮﺑ ﺎﮑﯾﺮﻣآ ﺪﻨﻧﺎﻣ ﻪﺘﻓﺮﺸﯿﭘ يﺎﻫرﻮﺸﮐ )

،

NIH

2008

،

(

ﯽﯾﺎـﭘورا يﺎﻫرﻮﺸﮐ )

ﻦـﺴﻧﺎﯾ

،

1

2009 ا و

(

ﺎﯿﻟاﺮﺘـﺳ ) ﺖـﻓﺎﺑ ﮏـﻧﺎﺑ

ﯽﺸﻫوﮋﭘ ﻮﺘﯿﺘﺴﻧا

2

ﯽﻠﺳو ، 2007 ( ﺎﺑ ﮏﻧ و ﯽﺘﻓﺎـﺑ نﻮﮔﺎـﻧﻮﮔ يﺎـﻫ

ياﺮﺑ ﯽﮑﯿﺘﻧژ ﯽﺳرﺮﺑ

ﯽﮑﺷﺰﭘ يﺎﻫ ﯽﮑﯿﺘﻧژ و

ﻪﺘﺧﺎﺳ ﺖـﺳا هﺪﺷ .

ياﺮﺑ ﺖﺧﺎﺳ ﮏﻧﺎﺑ ﻦﯿﻨﭼ ﯽﯾﺎﻫ

، ﺖﺴﺨﻧ ﺑ نارﺎﻤﯿﺑ ﻪ بﺎـﺨﺘﻧا ﺖﻗد

ﯽﺑﺎﯾزرا و هﺪﺷ ﺮﺑ ﯽﺼﯿﺨﺸﺗ يﺎﻫ

ﺎﭘﯾ ﻪ ﻪﻘﺒﻃ يﺪﻨﺑ ﻦﯿـﺑ يﺎﻫ ﻤﻟا ﻠ ﯽـﻠ

ﻖﻓاﻮﺗ ﺎﺑ ﻪﮐ ﻻﺎﺑ يﺮﯾﺬﭘ

ﺖـﺳا هاﺮـﻤﻫ ﯽﯾ

ﯽـﻣ مﺎـﺠﻧا دﻮـﺷ

ﻦﯿـﻨﭼ .

ﻪﻧﻮﻤﻧ ﺑ ﯽﯾﺎﻫ ﻪ رد ﺎﯾ ﯽﺋاﺪﻫا رﻮﻃ ﺮﺑاﺮﺑ

ﺰـﮐاﺮﻣ ﻪﺑ دﺰﻣرﺎﮐ ﺖﻓﺎﯾرد

نﻮﮔﺎﻧﻮﮔ ﯽﺸﻫوﮋﭘ رﻮﺸﮐ رد

ﺎﻫرﻮﺸﮐ ﺮﯾﺎﺳ و ﻓ

ـﺳﺮ هدﺎﺘ و هﺪـﺷ

ﻪﺘﻓﺎﯾ يﺎﻫ ﯽﺸﻫوﮋﭘ ﻪﻧﻮﻤﻧ زا ﻪﮐ يﺎﻫ

ﻪﺑ هﺪﺷدﺎﯾ ﯽﻣ ﺖﺳد ﺪﻨﯾآ رد

ﺰﯿﻧ هﺪﻨﻨﮐاﺪﻫا ﮏﻧﺎﺑ رﺎﯿﺘﺧا ﺘـﺷاﺬﮔ

ﻪ ﯽـﻣ

ﺎـﺗ دﻮـﺷ مﺎـﺠﻧا نﺎـﮑﻣا

ﯽﺳرﺮﺑ ﯽﻠﯿﻠﺤﺗاﺮﻓ يﺎﻫ ﻢﻫاﺮﻓ هﺪﻨﻨﮐاﺪﻫا ﺰﮐﺮﻣ ياﺮﺑ ار

ﺪـﻨﮐ ﺎـﺑ .

ﻪﻧﻮﻤﻧ لﺎﺳرا و يراﺬﮔﺪﮐ ﺑ ﺎﻫ

ﻪ ترﻮﺻ ﯽﺑ

3

مﺎﻧ ﺎـﻬﻧآ ﺖـﯾﻮﻫ ﻪﮐ

ﺲــﭘ و ﺶﯾﺎــﻣزآ مﺎــﺠﻧا زا ندﺎﺘــﺳﺮﻓ

ﻞــﺑﺎﻗ ﺞﯾﺎــﺘﻧ ،ﺖــﺳا مﻼــﻋا

ﯽﻣ زا ناﻮﺗ ﺖـﺳد يرﺎـﮐ ﺎـﯾ و تﺎـﻋﻼﻃا ﯽﻟﺎـﻤﺘﺣا

4

يﺮﯿﮔﻮـﺳ

5

ﺶﯿﭘ دﺮﮐ يﺮﯿﮔ .

ﻦﯾا زا ﻪﺘﻓﺎﯾ ور يﺎﻫ ﻦﯿﻨﭼ ﺶﻫوﮋﭘ ﯾﺎﻫ ﺮـﻈﻧ زا ﯽ

ﯽﻤﻠﻋ ﺪﻨﺘﺴﻫ يﺮﺗﻻﺎﺑ رﺎﺒﺘﻋا ياراد ﯽﻣ ﯽﺘﺣ و

ﻧاﻮﺗ ﻨ ﯽﺣاﺮﻃ رد ﺪ

نﺎﻣرد يﺎﻫ ﮑﺷﺰﭘ ﺰﯿﻧ ﯽ ﻪﺑ ﺮﺑ رﺎﮐ هد ﻧﻮﺷ ﺪ .

تﻼﮑﺸﻣ زا ﯽﮑﯾ

ﯽـﺳرﺮﺑ گرﺰـﺑ يﺎـﻫ

هﺪـﻨﮐاﺮﭘ ﯽـﮑﯿﺘﻧژ ،

ﻧﻮﮕﻤﻫﺎﻧ ﻪﻧﻮﻤﻧ ﯽ يداﮋـﻧ يﺎـﻬﻫوﺮﮔ رد ﺎـﻫ نﻮﮔﺎـﻧﻮﮔ

ا .ﺖـﺳا ز

ﻦﯾا ور نآ زا ﺎﺟ ﺖـﯿﻌﻤﺟ ﻦﯾا ﯽﮑﯿﺘﻧژ رﺎﺘﺧﺎﺳ ﻪﮐ

ـﻨﮐاﺮﭘ يﺎـﻫ هﺪ

ﺖﺳا توﺎﻔﺘﻣ

، ﻢﯿﻤﻌﺗ ﻪـﺘﻓﺎﯾ يﺮﯾﺬﭘ ﺎـﻫ

ﯽـﻣ ﺮـﺘﻤﮐ .دﻮـﺷ

زا ﯽـﮑﯾ

يروآدﺮـﮔ ﯽﺗﻼﮑـﺸﻣ ﻦﯿـﻨﭼ ﻞـﺣ ياﺮﺑ ﯽﺣﻼﺻا يﺎﻫدﺮﮑﯾور ﻪﻧﻮﻤﻧ ﻤﻫ يﺎﻫ ﮕ ﺑ ،يداﮋﻧ هوﺮﮔ ﮏﯾ رد نﻮ ﻪ

هﮋﯾو ﻢﻫاﺮـﻓ ندﺮـﮐ

ﻦﯾﺪﻨﭼ داﻮﻧﺎﺧ زا ﻪﻧﻮﻤﻧ ه

گرﺰﺑ يﺎﻫ ﺖﺳا

. ﻪﺑ ﺮﻈﻧ هزاﺪﻧا ﯽﮔرﺰﺑ

ﻪــﻧﻮﻤﻧ ﻦﯿــﻨﭼ ،ناﺮــﯾا رد هداﻮﻧﺎــﺧ يﺮــﯿﮔ

و ﯽــﻤﻠﻋ يﺎــﻫ ﺮــﺒﺘﻌﻣ

مﺎﺠﻧا ﯽﻧﺪﺷ هدﻮﺑ ﺖﺧﺎﺳ و

ﯽـﻣ ﺎـﻬﻨﺗ ﻪـﻧ ﯽﮑﻧﺎـﺑ ﻦﯿـﻨﭼ رد ﺪـﻧاﻮﺗ

ﺑﺎ ندﺮﺑﻻ ﺖـﯿﻔﯿﮐ ﺶﻫوﮋـﭘ يﺎـﻫ

ـﻣ ﯽـﮑﯿﺘﻧژ ﺆ

ﺪـﺷﺎﺑ ﺮﺛ

، ﻪـﺑ ﻪـﮑﻠﺑ

ﻢﯿﻤﻌﺗ نﺎﮑﻣا ﯽﺑﺎﯾزرا يﺮﯾﺬﭘ

ﯽـﺳرﺮﺑ يﺎـﻫ مﺎـﺠﻧا ﺮﯾﺎـﺳ رد هﺪـﺷ

ﺎﻫرﻮﺸﮐ ﺰﯿﻧ ﺪﻨﮐ ﮏﻤﮐ

ﻪـﻧﻮﻤﻧ ياﺮـﺑ . ﯽـﺳرﺮﺑ

ﯽـﻠﯿﻠﺤﺗاﺮﻓ يﺎـﻫ

داد نﺎﺸﻧ ه ﺪﻧا ﻞـﻟا ﻪﮐ ﯽـﻠﭘ

C

ﻢـﺴﯿﻓرﻮﻣ

T102C

نژ ﮐﻨ هﺪـﻨﻨﮐﺪ

زا ﯽـــﮑﯾ هﺪـــﻧﺮﯿﮔ

ﻦﯿﻧﻮﺗوﺮـــﺳ يﺎـــﻫ )

HTR2A

(

6

زوﺮـــﺑ رد

ﯽﯾﺎـﭘورا ﺖﯿﻌﻤﺟ رد ﺎﯿﻧﺮﻓوﺰﯿﮑﺳا ﺶـﻘﻧ رﺎـﺒﺗ

دا

؛در ﻦﯿـﻨﭼ ﯽـﻟو

ﻪﻄﺑار ﯽﯾﺎﯿﺳآ ياﺮﺑ يا يﺎﻫرﺎﺒﺗ

روﺎﺧ رود ﺖـﺳا هﺪـﺸﻧ شراﺰـﮔ

ﯽﮑﻠﻤﻟاﺪﺒﻋ)

،

7

نﻮﺋارﺎﻓ ﺖﻠﮔ ،

8

ﮓﻧﻮﺴﺗ و

9

،

10

2004 ( . زا ﻦﯾا ور

مﺎﺠﻧا ﺶﻫوﮋﭘ يﺎﻫ ﯽﻣ ﯽﮑﯿﺘﻧژ ﻧاﻮﺗ

ﻨ ﺪ ﺸﻧ ﻫد نﺎ ﻨ ﺪ ﯽـﻧاﺮﯾا مﻮﻗ ﻪﮐ

ﻪﺑ ماﺪﮐ ماﻮﻗا زا ﮏﯾ هﺪﺷدﺎﯾ

ﻦﯿـﻨﭼ مﺎـﺠﻧا ياﺮـﺑ .ﺖﺳا ﺮﺘﮑﯾدﺰﻧ

ﺳرﺮﺑ ﯽ ﯽﯾﺎﻫ ﻪﻧﻮﻤﻧ يﺎﻫ ﯽﻤﻧ هﺪﻨﮐاﺮﭘ ﻧاﻮﺗ

ﻨ

ﻞـﺑﺎﻗ ﺞﯾﺎـﺘﻧ ﺪ يدﺎﻨﺘـﺳا

ﻫد ﻪﺋارا ﻨ ﺪ و ﻞـﮐ هﺪـﻧﺮﯿﮔﺮﺑرد ﻪـﮐ ﯽـﮑﯿﺘﻧژ ﮏـﻧﺎﺑ ﮏﯾ دﻮﺟو

ﺑ ناﺮﯾا ﺖﯿﻌﻤﺟ ﻪ

ﺖﯿﻣﻮﻗ ﺰﯿﻧ و مﺎﻋ رﻮﻃ ﺪـﺷﺎﺑ رﻮـﺸﮐ نورد يﺎﻫ

نﺎﮑﻣا رﺮﺑ مﺎﺠﻧا ﯽﺳ يﺎﻫ ﯽﻣ ﻢﻫاﺮﻓ ار ﺎﺸﮕﻫر .دزﺎـﺳ

ﻦـﯾا رد ﺎـﺟ ﮏﻧﺎﺑ زا ﻪﻧﻮﻤﻧ ﺪﻨﭼ

ﻦﯿﺑ دﻮﺟﻮﻣ يﺎﻫ ﺎﺑ ﺮﺘﺸﯿﺑ ﯽﯾﺎﻨﺷآ ياﺮﺑ ﯽﻠﻠﻤﻟا

رﺎﮐ ﺪﻧور نﺎﻧآ

ﯽﻣ ﯽﻓﺮﻌﻣ .ﺪﻧﻮﺷ

1 - ﻣ ﺆ ﻪــﺴﺳ ﺶﻫوﮋــﭘ يﺎــﻫ ﯽﻠﻧﺎﺘــﺳا ﯽﮑــﺷﺰﭘ )

11

،

SMRI

2008 ( ﺮﻣ ﻦﯾﺮــﺗﺮﺒﺘﻌﻣ زا ﯽــﮑﯾ ا

ﺰــﮐ ﯽــﺸﻫوﮋﭘ ﺖــﺴﯾز

ﺘﺧﺎﻨــﺷ ﯽ

ﺖﺳا نﺎﻬﺟ رد ﯽﮑﺷﺰﭙﻧاور .

ﻣ ﻦﯾا رد ﺆ ﻪﺴﺳ يﺰـﻐﻣ ﻪﻋﻮﻤﺠﻣ ود

گﺮــﻣ زا ﺲــﭘ مﺎــﺠﻧا ياﺮــﺑ

ﯽــﺳرﺮﺑ يﺎــﻫ ﺎــﺘﻤﻫ هﺪــﺷ ﻪــﻨﯿﻣز رد

ﺐﺒـﺳ ـﺳﺎﻨﺷ نﺎـﻣرد و ﯽ ا

لﻼﺘــﺧ يﺎـﻫ ﯽـﺒﻄﻗود و ﺎﯿﻧﺮﻓوﺰﯿﮑــﺳا

،

آدﺮﮔ يرو ﺪﺷ ا ه .ﺖﺳ

2 - و ﯽﺸﻫوﮋﭘ هﺎﮕﺸﯾﺎﻣزآ ﻪﻋﻮﻤﺠﻣ

مﻮﯿﺳﺮﺴﻨﮐ ﺐﯿـﺳآ

ﯽـﺳﺎﻨﺷ

ﺒﺼﻋ ﯽ

12

ﺰﻐﻣ ) ،

SMRI

2008 (

، ﻪﻋﻮﻤﺠﻣ ﺎـﺑ يا 60 ﻞﻣﺎـﺷ ﻪـﻧﻮﻤﻧ

15 ﺮﻫ ياﺮﺑ ﻪﻧﻮﻤﻧ ﮏﯾ

زا ﺧا لﻼﺘ يﺎﻫ ﯽـﺒﻄﻗود ،ﺎﯿﻧﺮﻓوﺰﯿﮑﺳا و

هاﻮﮔ هوﺮﮔ و ﯽﺳﺎﺳا ﯽﮔدﺮﺴﻓا ﯽﻣ

ﺪﺷﺎﺑ ﺎﻫﺪـﺻ رﺎـﯿﺘﺧا رد ﻪـﮐ

ﻓﺮﮔ راﺮﻗ ﺮﮕﺸﻫوﮋﭘ ﺘ

هد نﻮﻨﮐ ﺎﺗ و ﻪ ﻪﻟﺎﻘﻣ ﺎﻫ

ﺸﻫوﮋﭘ رد ﯽ هرﺎﺑ ﻦﯾا

ﺶﻫوﮋﭘ ﺑ ﺎﻫ ﻪ .ﺖﺳا هﺪﯿﺳر پﺎﭼ

3 -

ﻦﯿـﺑ ﯽـﮑﯿﺘﻧژ ﮏﻧﺎﺑ

ﺰـﻐﻣ ﯽـﻠﻠﻤﻟا نﺎﺘـﺳرﺎﻤﯿﺑ)

ﮏـﻣ ﻦﯿـﻟ ،

2003 (:

ﮏـــﻧﺎﺑ ﻦـــﯾا نﺎﺘـــﺳرﺎﻤﯿﺑ رد

ﮏـــﻣ ـــﻟ ﯿ رد ﻦ دراورﺎـــﻫ

ﻪﯾﺎﭘ يراﺬﮔ ﺖﺳا هﺪﺷ و

ﻪﻧﻮﻤﻧ يﺰﻐﻣ يﺎﻫ گﺮﻣ زا ﺲﭘ

يرﺎﯿﺴﺑ

هوﺮــﮔ و نارﺎــﻤﯿﺑ زا هاﻮــﮔ

دراد رﺎــﯿﺘﺧا رد ار ﻦــﯾا ﮏــﻤﮐ ﻪــﺑ .

ﻪﻧﻮﻤﻧ ﺎﻫ ﯽﺳرﺮﺑ ﯽﭘ و ﯽﮑﺷﺰﭙﻧاور يﺎﻫ هدﺮﺘﺴﮔ ﯽﺘﺧﺎﻨﺷ

يا مﺎﺠﻧا

ا هﺪﺷ .ﺖﺳ

4 - ﯽﻧﺎﺴﻧا ﮏﯿﺘﻧژ ﻊﺑﺎﻨﻣ ﺰﮐﺮﻣ )

13

لﻼﺘـﺧا ﯽـﻠﻣ ﻮﺘﯿﺘﺴﻧا يﺎـﻫ

ﺐﺼﻋ ﯽﺘﺧﺎﻨﺷ ﻪﺘﮑﺳ و

14

يﺰﻐﻣ ، 2011 ( ﺮﺒﺘﻌﻣ ﺰﮐاﺮﻣﺮﮕﯾد زا ﺰﯿﻧ

ﺳﺮﺘﺳد ﺎﺑ ﻪﮐ ﺖﺳا ﺎﯿﻧد ﯽ

ﻪﺑ ﻪﻧﻮﻤﻧ يﺰﻐﻣ يﺎﻫ نﻮﮔﺎـﻧﻮﮔ

، مﺎـﺠﻧا

ﺶﻫوﮋﭘ يﺎﻫ ﯿﻨﺑ ﺎد ﻪﻨﯿﻣز رد ار يدﺎﯾز ﯽﻨﯿﻟﺎﺑ و ي ﯽﺒـﺼﻋ هﺎﮕﺘﺳد

ﯽﭘ ﺶﻧاد و ﯽﺳﺎﻨﺷ

، ﻢﻫ ﻦﯿﻨﭼ ﺺﯿﺨﺸﺗ

، ﺶﯿﭘ و نﺎﻣرد يﺮـﯿﮔ

زا

يرﺎﻤﯿﺑ يﺎﻫ ﺐﺼﻋ ﯽﺘﺧﺎﻨﺷ

، نﺎﮑﻣا .ﺖﺳا ﻪﺘﺧﺎﺳ ﺮﯾﺬﭘ

1

شور ﻦﯾا رد حﺮﻃ ﻪﻧﻮﻤﻧ ﯽﻧاﺮﯾا ﯽﮑﺷﺰﭙﻧاور نارﺎﻤﯿﺑ زا ﯽﻗاﺰﺑ يﺎﻫ

ﯽــﺴﮐﻮﺋد ﺪﯿــﺳا ﮏــﻧﺎﺑ ﻞﯿﮑــﺸﺗ ياﺮــﺑ ﮏــﯿﺌﻠﮐﻮﻧﻮﺒﯾر

، نﺎــﯿﻣ زا

ﺎﭘﺮـﺳ نارﺎـﻤﯿﺑ ﯾ

ﻪـﻌﺟاﺮﻣ ﯽ

ﯽـﺷزﻮﻣآ ﺰـﮐﺮﻣ ﻪـﺑ هﺪــﻨﻨﮐ -

ﯽﻧﺎــﻣرد

ﯽﮑﺷﺰﭙﻧاور و ناﺮﯾا

نﺎﺘﺳرﺎﻤﯿﺑ مﺮـﮐا لﻮﺳر

ناﺮـﻬﺗ (ص) ﺰـﯿﻧ و

ﺶــﺨﺑ رد يﺮﺘــﺴﺑ نارﺎــﻤﯿﺑ ﻒــﻠﺘﺨﻣ يﺎــﻫ

هﺪــﺷدﺎﯾ ﺰــﮐاﺮﻣ ﻪــﮐ

_______________________________________

1- Jansen

2- Wesley Research Institute Tissue Bank 3- blind 4- manipulation 5- bias

6- hydroxytryptamine (serotonin) receptor 2A 7-Abdolmaleky 8- Faraone

9- Glatt 10- Tsuang 11- Stanley Medical Research Institute

12- Brain Research Laboratory & Brain Collection:

Neuropathology Consortium 13- Human Genetics Resource Center

14- National Institute of Neurological Disorders and Stroke

Downloaded from ijpcp.iums.ac.ir at 12:01 CEST on Wednesday October 8th 2014

(4)

327

ﺖﺳد ﻢﮐ ﺺﯿﺨـﺸﺗ و ﻪﺘـﺷﺬﮔ ﺎـﻬﻧآ يﺮﺘـﺴﺑ تﺪﻣ زا ﻪﺘﻔﻫ ﮏﯾ

ﺗ ﺞﻟﺎـﻌﻣ ﮏـﺷﺰﭙﻧاور ﻂـﺳﻮﺗ يرﺎﻤﯿﺑ ﯾﺄ

هﺪـﺷ ﺪـﯿ

،دﻮـﺑ شور ﻪـﺑ

ﻪﻧﻮﻤﻧ سﺮﺘﺳد رد يﺮﯿﮔ يروآدﺮﮔ

.ﺪﻧﺪﺷ ﻪﻧﻮﻤﻧ ﯽﻧﺎﻣز ﺎﺗ يﺮﯿﮔ

ﺖﻓﺎﯾ ﻪﻣادا رﺎﻤﺷ ﻪﮐ

ﻪﻧﻮﻤﻧ يﺎﻫ ﺑ مزﻻ ﻪ ﺖﺳد ) ﺪـﯾآ زا ﺶﯿـﺑ 300

ﻪﻧﻮﻤﻧ .(ﻪﻧﻮﻤﻧ نارﺎﻤﯿﺑ زا ﺎﻫ

رﺎﭼد ﯿﻧﺮﻓوﺰﯿﮑﺳا ﺎ

ﻼﺘﺧا ، ل ﻗود ،ﯽﺒﻄ

لﻼﺘﺧا

،ﯽﺳﺎﺳا ﯽﮔدﺮﺴﻓا ﯽﺳاﻮﺳو لﻼﺘﺧا

- لﻼﺘﺧا و يرﺎﺒﺟا

ﻪﺟﻮﺗ دﻮﺒﻤﮐ ﺎﺑ هاﺮﻤﻫ ﯽﻟﺎﻌﻓ ﺶﯿﺑ .ﺪﻧﺪﺷ بﺎﺨﺘﻧا

بﺎـﺨﺘﻧا ﺖﻠﻋ

نﺎﺘــﺳرﺎﻤﯿﺑ ﻦــﯾا ــﺑ ﺎــﻫ

ﻪ ﻪــﻧﻮﻤﻧ ﺰــﮐاﺮﻣ ناﻮــﻨﻋ ــﯿﮔ

يﺮ

، آدﺮــﮔ يرو

ﻪﻧﻮﻤﻧ زا ﯽﻓﺎﮐ يﺎﻫ ﻫ

ﻤ ﻪ هوﺮﮔ و ﺎﻫ ﻪﺘﺳﺎﺧﺮﺑ و يﺮﻬـﺷ ﻖﻃﺎـﻨﻣ زا

.دﻮﺑ ﺮﻬﺷ ﻪﯿﺷﺎﺣ

د ،نارﺎﻤﯿﺑ بﺎﺨﺘﻧا ﻦﻤﺿ ر

ﯽﮕﻧﻮﮕﭼ هرﺎﺑ اﺮﺟا تروﺮﺿ و

ي

نآ ﺪﯾاﻮﻓ ،حﺮﻃ و

ﻪﻧﺎﻣﺮﺤﻣ ﺢﯿﺿﻮﺗ نارﺎﻤﯿﺑ ياﺮﺑ تﺎﻋﻼﻃا ندﻮﺑ

هداد ﯽﻓﺎﮐ و ﺪﺷ

ﺎـﻬﻧآ زا ﻪﻧﻮﻤﻧ ياﺪﻫا ياﺮﺑ ﺖﻘﻓاﻮﻣ ترﻮﺻرد

ﺖﯾﺎﺿر ﯽﻣ ﻪﺘﻓﺮﮔ ﻪﻣﺎﻧ ﻪﺑ ﺎﻬﻧآ ﻞﯾﺎﻤﺗ ترﻮﺻ رد .ﺪﺷ

رد ﺖﮐﺮﺷ

ﻪﺒﺣﺎـﺼﻣ رﺎـﻤﯿﺑ ﺎـﺑ مود ﮏـﺷﺰﭙﻧاور ،حﺮﻃ ﯽـﻣ

ﻮـﻤﻧ د . ﻪﺒﺣﺎـﺼﻣ

ﺑﻪ ترﻮﺻ ﻪﻤﯿﻧ ﺎﺳ ﻪﺘﻓﺎﯾرﺎﺘﺧ ياﺮﺑ

1

لﻼﺘﺧا رﻮـﺤﻣ يﺎـﻫ ﮏـﯾ

، ﺮـﺑ

ﭘﺎ ﻪــﯾ ﺪــﯾﺪﺠﺗ ﻦﯿﻣرﺎــﻬﭼ يﺎــﻫرﺎﯿﻌﻣ ــﺼﯿﺨﺸﺗ يﺎــﻤﻨﻫار ﺮــﻈﻧ

ﯽ و

يرﺎﻣآ لﻼﺘﺧا ﺎﻫ ) ﯽـﻧاور ي

DSM-IV-TR

(

2

و ﺑ هﺮـﻬ يﺮـﯿﮔ از

ﺶﺳﺮﭘ ﻪﻣﺎﻧ

SCID-I

ﺖﺳﺮﻓ)

3

،

4

رﺰﺘﯿﭙـﺳا نﻮـﺒﯿﮔ ،

5

ﺰﻣﺎـﯿﻠﯾو و

6

،

7

2006 ( و ﯽﯾﺎﯾﺎﭘ ناﺮﯾا رد ﻪﮐ نآ ﯽﯾاور

ﺗﺄ ﺮﮔ ﺪﯿﯾ ﺪﯾد ه ) و ﯽﻔﯾﺮﺷ

ﺎﮑﻤﻫ ،نار 2007 (

، ﻪﺒﺣﺎﺼﻣ رد .ﺪﺷ مﺎﺠﻧا

ﯽـﮔﮋﯾو ﯽـﺧﺮﺑ يﺎـﻫ

ﺖﯿﻌﻤﺟ ﻪـﻠﻤﺟ زا ﯽﺘﺧﺎﻨﺷ ،ﺲﻨـﺟ ،ﻦـﺳ ،ﯽﮔداﻮﻧﺎـﺧ مﺎـﻧ و مﺎـﻧ

،ﺖﻧﻮﮑﺳ ﻞﺤﻣ ،داﮋﻧ و ﺖﯿﻣﻮﻗ ﺖﯿﻌﺿو

ﺗﺄ ،ﻞﻫ رﺎﻤـﺷ ﺪـﻧزﺮﻓ نا

،

ناﺰــﯿﻣ يﺮﺘــﺴﺑ) ﻪــﻌﺟاﺮﻣ عﻮــﻧ ،ﯽﻠﻐــﺷ ﻪﻘﺑﺎــﺳ ،تﻼﯿــﺼﺤﺗ ﺎــﯾ

ﺎﭘﺮــﺳ ﯾ

،(ﯽ ﻊﺑﺎــﻨﻣ ﻪــﺑ هدﺮﺑرﺎــﮐ هﺪــﺷ ﮏــﭼ ﻞــﯿﻤﮑﺗ ياﺮــﺑ ﺖــﺴﯿﻟ

ﺎﺑ ﻪﺒﺣﺎﺼﻣ) يﺮﺘﺴﺑ رﺎﻤﯿﺑ

ﺎﯾ ﺎﭘﺮﺳ ﯾ ﯽ

، (نﺎﮕﺘﺴﺑ ﺎﺑ ﻪﺒﺣﺎﺼﻣ

، تﺪـﻣ

ﻪﻘﺑﺎـﺳ دﻮـﺟو ،ﯽﮔداﻮﻧﺎـﺧ ﻪﻘﺑﺎـﺳ ،ﺖـﺴﯿﻟ ﮏـﭼ ﻞـﯿﻤﮑﺗ نﺎﻣز ﯽﮑﺷﺰﭙﻧاور يرﺎﻤﯿﺑ و

ﯽﮑﯿﺘﻧژ يرﺎﻤﯿﺑ ﺎﯾ

رد ﯽﺛرا نﺎﮕﺘﺴﺑ ﻪﺟرد

،هداﻮﻧﺎﺧ مود و لوا يروآدﺮﮔ

. ﺪﺷ

ﮏﭼ رد

ﺺﯿﺨـﺸﺗ ﺖـﺴﯿﻟ

، لﻼﺘـﺧا ﺮـﺿﺎﺣ و

8

ﺮـﻤﻋ ﻪـﻤﻫ

9

ﺑﻪ ترﻮﺻ دﺮـﺸﻓ ﺮﺑ ه ﭘﺎ ﻪـﯾ يﺎـﻫرﺎﯿﻌﻣ

DSM-IV-TR

و ﺺﺨـﺸﻣ

ﺪﺷ يراﺬﮔﺪﮐ .

ﻫ ﻤ ﻪ

فﺪـﻫ ﻢـﺋﻼﻋ ﻼﺘـﺧا

10

ل ﺎـﻫ ي دﺎـﯾ و هﺪـﺷ

يدﻮﺒﻤﻫ رﺎﻤﯿﺑ رد ﺎﻫ ﯽﺳرﺮﺑ

ـﯾدﺮﮔ .ﺪ نوﺰـﻓا

ﺺﯿﺨـﺸﺗ ﺮـﺑ

، ﺮـﻫ

فﺪﻫ ﻢﺋﻼﻋزا ﮏﯾ ﺰﯿﻧ

ﮏﭼ رد ﺖﺴﯿﻟ ﺖﻣﻼﻋ ﯽﻣ يراﺬﮔ .ﺪﺷ

ﺲﭘ ﮏﭼ ﻞﯿﻤﮑﺗ و رﺎﻤﯿﺑ ﺎﺑ ﻪﺒﺣﺎﺼﻣ زا نﺎﮕﺘﺴﺑ ياﺮﺑ ﺖﺴﯿﻟ

رد سﺮﺘـــﺳد

،يو ءﺎـــﻀﻣا و ﺖﯾﺎـــﺿر ترﻮـــﺻرد ﻪـــﻧﺎﻫﺎﮔآ

ﺖﯾﺎﺿر ﻪﻣﺎﻧ ﻫ ﻤ ﻪ ﻞﺣاﺮﻣ دﺎﯾ ﯽﻣ مﺎﺠﻧا هﺪﺷ ﻪﻧﻮﻤﻧ ﺎﺗ ﺪﯾدﺮﮔ

ﯽﯾﺎـﻫ

ياﺮﺑ ﯽﺳرﺮﺑ ﻢﻫاﺮﻓ ﻢﻫ ﯽﮔداﻮﻧﺎﺧ .ددﺮﮔ

ﺖﯾﺎﺿر ﻦﺘﻓﺮﮔ رد ﻪﻣﺎﻧ

ﻢـﯾﻼﻋو هدﻮـﺒﻧ يرﺎـﻤﯿﺑ دﺎـﺣ ﻪـﻠﺣﺮﻣ رد ﻪﮐ ﺪﺷ مﺎﺠﻧا ﯽﻄﯾاﺮﺷ هرﺎـﺑ رد ﺢﯿـﺿﻮﺗ زا ﺲـﭘ .ﺖـﺳا هدﻮـﺑ ﯽﺒـﺴﻧ لﺮـﺘﻨﮐرد يرﺎﻤﯿﺑ

ﻪﺘﺷﺎﮕﻧ تﺎﮑﻧ ﺖﯾﺎﺿر مﺮﻓ رد هﺪﺷ

ﯿﺑ ياﺮﺑ ﻪﻣﺎﻧ ﯽﺑ نارﺎﻤ

داﻮـﺳ و

ﺖﯾﺎﺿر مﺮﻓ ﻪﻌﻟﺎﻄﻣ زا ﺲﭘ داﻮﺳ ﻦﺘﺷاد ترﻮﺻ رد ﻂـﺳﻮﺗ ﻪﻣﺎﻧ

رﺎﻤﯿﺑ

، ﺖﯾﺎﺿر ﻪﺘﻓﺮﮔ ﻪﻣﺎﻧ ﯽﻣ

نارﺎﻤﯿﺑ هرﺎﺑ رد ﯽﺒﺘﮐ ﺖﯾﺎﺿر .ﺪﺷ

ﯽﻧﻮﻧﺎﻗ هﺪﻨﯾﺎﻤﻧ ﺎﯾ نﺎﮕﺘﺴﺑ زا ،ﮏﯿﺗﻮﮑﯿﺴﭘ نﺎﻧآ

ﻪـﺘﻓﺮﮔ ﯽـﻣ .ﺪـﺷ

نوﺰﻓا

،نارﺎﻤﯿﺑ ﺮﺑ ﺎﺑ

ﺑ ﺰﯿﻧ ﯽﻫوﺮﮔ ﻪ

هوﺮـﮔ ناﻮﻨﻋ هاﻮـﮔ

ﻪﺒﺣﺎـﺼﻣ

ﺪﺷ يﺎﻫرﺎﯿﻌﻣ ﻪﮐ رو

11

دو آ ﺎﻬﻧ

، نﺎﺴﮑﯾ ندﻮﺑ هوﺮﮔ ﺲﻨـﺟ ،ﯽﻨﺳ

و ﺖﯿﻌﻤﺟ يﺎﻫﺮﯿﻐﺘﻣ ﺮﯾﺎﺳ ﯽﺘﺧﺎﻨﺷ

نارﺎـﻤﯿﺑ هوﺮـﮔ ﺎـﺑ ﻦﺘـﺷاﺪﻧ و

ﯽﮑﺷﺰﭙﻧاور يرﺎﻤﯿﺑ ﻦﯿﺸﯿﭘ

و ﻧﻮﻨﮐ ﺮﺑ ﯽ ﻪﯾﺎﭘ و ﯽﺼﯿﺨﺸﺗ ﻪﺒﺣﺎﺼﻣ

ﮏﭼ ﺖﺴﯿﻟ - ٍٍ

I

و ﺎﻬﻧآ رد

SCID

نﺎﮕﺘﺴﺑ لوا ﻪﺟرد ﻧآ

نﺎ دﻮﺑ

1

.

ﻪﺒﺣﺎـﺼﻣ مﺎـﺠﻧا زا ﺲـﭘ ﺎـﺑ

هوﺮـﮔ و نارﺎــﻤﯿﺑ هاﻮـﮔ

قاﺰــﺑ ﻪـﻧﻮﻤﻧ ،

ﻪﺑ ناﺰﯿﻣ ﯽﻠﯿﻣود ﺮﺘﯿﻟ ﺖﺴﺷزا ﺲﭘ و

ﺷ نﺎﻫد يﻮ ﻪﯾﺎﭘﺮﺑ يﺎﻤﻨﻫار هﺪﻧزﺎـﺳ

نژاروا ﺖــﯿﮐ

12

ودﻮــﯿﮐ ﯽــﻠﻠﻤﻟا ﻦﯿــﺑ ﺖﮐﺮــﺷ) ،

13

2012 ( رﺎــﻤﯿﺑ زا

،

ﻪﺘﻓﺮﮔ ﺎﺑ و هﺪﺷ ﯽـﻠﯿﻣ ود ﺮـﺘﯿﻟ دﻮـﺟﻮﻣ ﺖـﯿﮐرد ﻪـﮐ صﻮـﺼﺨﻣ ﻊﯾﺎـﻣ

ﺖﺳا

، طﻮﻠﺨﻣ .ﺪﯾدﺮﮔ ﺐﯿﮐﺮﺗ ﻦﯾا ﺞﻨـﭘ ﺎـﺗ قﺎـﺗا ﯽﻟﻮـﻤﻌﻣ يﺎـﻣد رد

يراﺪـــﻬﮕﻧ ﻞـــﺑﺎﻗ لﺎـــﺳ ﻪـــﺑ .ﺖـــﺳا

ﮏـــﻤﮐ ﻦـــﯾا شور ﺪﯿـــﺳا

ﯽﺴﮐﻮﺋد ياﺮـﺑ ﻻﺎـﺑ ﺖـﯿﻔﯿﮐ ﺎـﺑ و ﯽﻓﺎـﮐ ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﯽـﺳرﺮﺑ

يﺎـﻫ

ﯽﻣ ﻢﻫاﺮﻓ ﮏﯿﺘﻧژ ﻮﺷ

شور ﻪﺑ ﺖﺒﺴﻧ ﻪﮐ د ﻪﺑﺎـﺸﻣ يﺎـﻫ

ﺮﺘـﺸﯿﺑ ﻪـﺘﻓﺮﯾﺬﭘ

ﺷ ﺪ ) ه زﺮﺟار نارﺎـﮑﻤﻫ و

14

، 2007 ( زا و ﺮـﻈﻧ

يروآدﺮـﮔ ﯽﻧﺎـﺳآ و

ﻢﮐ ﻪﺑ ﺖﺒﺴﻧ ﺰﯿﻧ ندﻮﺑ ﻪﻨﯾﺰﻫ يروآدﺮﮔ

ﻪﻧﻮﻤﻧ ﯽﻧﻮﺧ يﺎﻫ دراد يﺮﺗﺮﺑ

.

جاﺮﺨﺘﺳا ﺪﯿﺳا ﺋد ﯽﺴﮐﻮ ﻪﻧﻮﻤﻧ زا ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﯽـﻗاﺰﺑ يﺎـﻫ

و هدﺎﺳ رﺎﯿﺴﺑ ﺮﻫ رد

آ

مﺎـﺠﻧا ﯽﻫﺎﮕـﺸﯾﺎﻣز ﺪـﺷ

ﺖـﺳا ﯽﻧ . ﻪـﯾﺎﭘ ﺮـﺑ

يﺎﻤﻨﻫار ﯿﮐ هﺪﻧزﺎﺳ ﺖﮐﺮﺷ نژاروا ﺖ

، ﺮﻫ ياﺮﺑ جاﺮﺨﺘـﺳا رﺎـﺑ

ﺪﯿﺳا ﯽـﺴﮐﻮﺋد

ﯽـﻠﯿﻣ ﻢﯿـﻧ ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﻪـﻧﻮﻤﻧ زا ﺮـﺘﯿﻟ

هﺪـﺷدﺎﯾ

ـﺑ ﻪ تﺪــﻣ ﮏـﯾ ﺎــﺗ ود يﺎــﻣد رد ﺖﻋﺎـﺳ 50

ﯽﺘﻧﺎــﺳ ﻪـﺟرد داﺮــﮔ

و ﻪــﺘﻓﺮﮔراﺮﻗ 20

ﺺﯿــﻠﺨﺗ صﻮــﺼﺨﻣ ﻊﯾﺎــﻣ ﺮــﺘﯿﻟوﺮﮑﯿﻣ ﺪﯿــﺳا

ﯽﺴﮐﻮﺋد ﺖﺳا دﻮﺟﻮﻣ ﺖﯿﮐ رد ﻪﮐ ﮏﯿﺌﻠﮐﻮﻧﻮﺒﯾر

، ﻪﺑ آ ا ن دوﺰﻓ ه

طﻮﻠﺨﻣ بﻮﺧ و ﯽﻣ

ﺷ ﻮ ﺑ و د ﻪ و يراﺪﻬﮕﻧ ﺦﯾ رد ﻪﻘﯿﻗد هد تﺪﻣ

ﺑ ﺲﭙﺳ ﻪ تﺪﻣ ﺞﻨـﭘ رد ﻪـﻘﯿﻗد 12000

ژﻮﻔﯾﺮﺘﻧﺎـﺳ ﻪـﻘﯿﻗد رد رود

ﯽﻣ دﻮﺷ هﺪﻧﺎﻤﺴﭘ يﻻﺎﺑ لﻻز ﻊﯾﺎﻣ .

ﻪـﻟﻮﻟ ﻪـﺑ ﯽﻟﻮﻠـﺳ يﺎﻫ يا

5/

1

ﯽﻠﯿﻣ ﺘﯿﻟ يﺮ ﺘﻨﻣ ﻘ ﻪـﺑ و هﺪﺷ ﻞ ﻞـﮑﻟا يوﺎـﺴﻣ راﺪـﻘﻣ

100 ﻪـﺑ % آ ن

هدوﺰﻓا ژﻮﻔﯾﺮﺘﻧﺎﺳ درﻮﻣ و هﺪﺷ هرﺎﺑود

تﺪـﻣ ﻪﺑ 10 راﺮـﻗ ﻪـﻘﯿﻗد

_______________________________________

1- semi-structured interview

2- Diagnostic and Statistical Manual of Mental Disorders (4th. ed.), Text Revision

3- Structured Clinical Interview for DSM-IV axis I disorders

4- First 5- Spitzer

6- Gibbon 7- Williams

8- current 9- life-time

10- target symptoms 11- inclusion criteria 12- Oragene kit 13- Kyodo International Inc.

14- Rogers

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(5)

328

Vol. 17 / No. 4 / Winter 2012

ﯽﻣ ﻪﮐ دﺮﯿﮔ ﺪﯿﺳا ﯽﺴﮐﻮﺋد بﻮـﺳر ﻪـﻟﻮﻟ ﻪـﺗ رد ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر

ﯽﻣ بﻮﺳر يﻻﺎﺑ ﻊﯾﺎﻣ .ﺪﯾﺎﻤﻧ ﺪﯿـﺳا

ﯽـﺴﮐﻮﺋد ﻪـﺑ ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر

آ و هﺪـﺷ ﻪﺘـﺷادﺮﺑ ﯽﻣار ﺪﯿـﺳا

ﯽـﺴﮐﻮﺋد رد ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر 100

ﺮﻓﺎــﺑ ﺮــﺘﯿﻟوﺮﮑﯿﻣ ﺎــﯾ ﺖــﯿﮐرد دﻮــﺟﻮﻣ ﯽــﺻﺎﺼﺘﺧا

آ ﻟﺎــﺧ ب ﺺ

ﻞﺣ ﯽﺘﻧﺎﺳ ﻪﺟرد رﺎﻬﭼ رد ﻪﮐ هﺪﺷ هﺎﻣ ياﺮﺑ داﺮﮔ

يﺎـﻬﻨﻣ ردو ﺎﻫ

20 ﯽﺘﻧﺎﺳ ﻪﺟرد لﺎﺳ ياﺮﺑ داﺮﮔ

يراﺪﻬﮕﻧ ﻞﺑﺎﻗ ﺎﻫ ا

راﺪـﻘﻣ .ﺖـﺳ

ﺪﯿﺳا ﯽﺴﮐﻮﺋد

ﯽـﻠﯿﻣ ﻢﯿـﻧ زا هﺪـﺷ جاﺮﺨﺘـﺳا ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﺮـﺘﯿﻟ

ﯽﻗاﺰﺑ طﻮﻠﺨﻣ ﺰﻧ

د ﻪـﺑ ﮏـﯾ 10

ﯽـﻣ مﺮـﮔوﺮﮑﯿﻣ

ـﺑ ﻪـﮐ ﺪـﺷﺎﺑ ياﺮ

ﺎﻫﺪﺻ آ ﺎﮐ ﯽﮑﯿﺘﻧژ ﺶﯾﺎﻣز ﯽﻓ

ﺖﺳا .

ﻪﺘﻓﺎﯾ ﺎﻫ ﺚﺤﺑ و

رد ﻪﻠﺣﺮﻣ ﺖﺴﺨﻧ ﮏﻧﺎﺑ ﻞﯿﮑﺸﺗ ﺪﯿﺳا

ﯽﺴﮐﻮﺋد ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر

،

فﺪــﻫ آدﺮــﮔ يرو 500 ﮏــﯾ لﻮــﻃ رد ﻪــﻧﻮﻤﻧ .دﻮــﺑ لﺎــﺳ

رﺎﻤــﺷ

ﻪﻧﻮﻤﻧ رد دﻮﺟﻮﻣ يﺎﻫ ﺮﻫ

و ﯽﺼﯿﺨﺸﺗ هوﺮﮔ هرﺎﭘ

ﺮﮕﯾد تﺎﻋﻼﻃا يا

رد

1لوﺪﺟ

ﻦـﯾا ﻪـﺑ ﺮـﻈﻧ .ﺖﺳا هﺪﺷ ﻪﺋارا ﻪـﮐ

ﯽـﺳرﺮﺑ ﺮﺘـﺸﯿﺑ ﺎـﻫ

ي

ﯽﮑﯿﺘﻧژ ﻪﺑ زﺎﯿﻧ ﻪﻧﻮﻤﻧ د يﺮﺘـﺸﯿﺑ يﺎﻫ

،درا ﺶﯾاﺰـﻓا رﺎﻤـﺷ ﻪـﻧﻮﻤﻧ و ﺎـﻫ

ﻢﻫ ﻪﯿﻬﺗ ﺪﯿـﺳا نﺎﻣز ﯽـﺴﮐﻮﺋد

ﮏـﯿﺌﻠﮐﻮﻧﻮﺒﯾر ﻪـﻧﻮﻤﻧ زا

يﺎـﻫ هزﺎـﺗ زا

فﺪﻫ ﻪﻠﻤﺟ يﺎﻫ

نﺎﯿﻣ ا تﺪﻣ ﯽﺳرﺮﺑ ﻦﯾ ﯽﻣ

.ﺪﺷﺎﺑ

ﺮـــﺑ ﻪـــﯾﺎﭘ

ﯽﺗرﻮـــﺻ رد ﯽـــﮑﯿﺘﻧژ ﮏـــﻧﺎﺑ ﻪﻣﺎﻨـــﺳﺎﺳا ﻪـــﮐ

ﺖﺳاﻮﺧرد اﻮﻣ نﺎﮔﺪﻨﻨﮐ

ﻓ ﺪﻨﺷﺎﺑ ﻖ

، ﺪﯿﮑﭼ ه حﺮﻃ زا يا ﯽـﺸﻫوﮋﭘ

ــﺧ رد ﻪــﮐ ﯽﺗﺎــﻋﻼﻃا ﺎــﺑ هاﺮــﻤﻫ ار دﻮ و ﯽﻟﺎــﻣ ﻊﺑﺎــﻨﻣ هﺪــﻧﺮﯿﮔﺮﺑ

تﺎﻧﺎﮑﻣا آ ﯽﻣ حﺮﻃ ياﺮﺟا ﯽﻫﺎﮕﺸﯾﺎﻣز ﺪﺷﺎﺑ

، ﯽﻤﻠﻋ يارﻮﺷ ﻪﺑ -

ﮏﻧﺎﺑ ﯽﯾاﺮﺟا ﯽﻣ

ﺪﻨﺘﺳﺮﻓ مﺎـﺠﻧا ﺖـﯿﻠﺑﺎﻗ و ﯽـﻤﻠﻋ رﺎـﺒﺘﻋا ارﻮـﺷ .

ﮏـﯾ ﯽـﻃ ار حﺮﻃ ﯽـﺳرﺮﺑ هﺎـﻣ

ﻮـﻤﻧ

ﺖـﻘﻓاﻮﻣ ترﻮـﺻرد و هد

،

ﻪﺑ هزاﺪﻧا ﺎﯾ ﯽﻗاﺰﺑ ﻪﻧﻮﻤﻧ ﯽﻓﺎﮐ

ﯽـﺴﮐﻮﺋد ﺪﯿـﺳا ﻠﮐﻮﻧﻮﺒﯾر

رد ﮏـﯿﺌ

رﺎــﯿﺘﺧا ناﺮﮕــﺸﻫوﮋﭘ ﯽــﻣ ﻪﺘــﺷاﺬﮔ

ﻮــﺷ موﺰــﻟ ترﻮــﺻرد .د

، دﺎﻬﻨﺸﯿﭘ ﻪﺑ ﯽﺣﻼﺻا يﺎﻫ ﯽﻣ هداد ﺰﯿﻧ ناﺮﮕﺸﻫوﮋﭘ

دﻮﺷ ﺪﻫاﻮﺷ ﺎﯾ

ﯽﻤﻠﻋ - ﺮﺘﺸﯿﺑ ﯽﯾاﺮﺟا ي

ﯽـﻣ ﺖﺳاﻮﺧرد ﻮـﺷ

اﺪـﻫا ﻪـﻨﯿﻣز ﺎـﺗ د ي

ﻪﻧﻮﻤﻧ ﻢﻫاﺮﻓ ﺎﻫ دﺮﮔ .د

داﺮﻓا و نارﺎﻤﯿﺑ ﻪﻧﺎﻣﺮﺤﻣ تﺎﻋﻼﻃا ﻆﻔﺣ ياﺮﺑ

،هاﻮـﮔ هوﺮـﮔ

ﻪﻧﻮﻤﻧ يراﺬﮔﺪﮐ ﺎﻫ ﯽﻣ

ﺷ ﻧﻮ ﺖﯾﻮﻫ ﺎﺗ ﺪ آ

.ﺪـﻧﺎﻤﺑ ﯽﻗﺎﺑ سﺎﻨﺷﺎﻧ ﺎﻬﻧ

ﻞــﺣاﺮﻣ مﺎــﺠﻧا زا ﺲــﭘ آ

ﯽﻫﺎﮕــﺸﯾﺎﻣز

، تﺎــﻋﻼﻃا ،ﯽــﺼﯿﺨﺸﺗ

ﯽﻣ ﻪﮐ ﯽﺗﺎﻋﻼﻃا يﺎﻬﻨﻣ) دﻮﺟﻮﻣ تﺎﻋﻼﻃا ﺮﯾﺎﺳو ﯽﯾوراد ﺪﻧاﻮﺗ

ﻪﺑ داﺮﻓا ﺎﯾ نارﺎﻤﯿﺑ ﺖﯾﻮﻫ ﯽﯾﺎﺳﺎﻨﺷ

ـﻣﺎﺠﻧﺎﯿﺑ هاﻮـﮔ هوﺮﮔ ياﺮـﺑ (ﺪ

ﻞﯿﻠﺤﺗ هداد رﺎﯿﺘﺧارد ﺎﻫ ﻪﺘﺷاﺬﮔ ناﺮﮕﺸﻫوﮋﭘ

ﯽﻣ

.دﻮﺷ

ﯽﻠﮐ ﺖﺳﺎﯿﺳ ﮏﻧﺎﺑ

لﺎﺳ ﻪﺳ ياﺮﺑ ﯽﮑﯿﺘﻧژ آ

ﻦـﯾا هﺪﻨﯾ ا

ﺖـﺳ

مﺎﺧ تﺎﻋﻼﻃا ﻪﺨﺴﻧ ﮏﯾ ﻪﮐ ﺰﯿﻧ

ﺎـﺗ دﺮـﯿﮔ راﺮﻗ ﮏﻧﺎﺑ رﺎﯿﺘﺧا رد

ﺮﯾﺎﺳ ﻂﺳﻮﺗ ﻪﮐ ﯽﺗﺎﻋﻼﻃا ﺎﺑ ناﺮﮕﺸﻫوﮋﭘ

ﯽﻣ ﺪﯿﻟﻮﺗ ددﺮﮔ

، مﺎﻏدا

درﻮﻣ ﺎﻬﻧژ ﻞﻣﺎﻌﺗ و هﺪﺷ ﻞﯿﻠﺤﺗ

.دﺮﯿﮔ راﺮﻗ ﻪﻧﻻﺎﺳود يﺎﻫ ﻦﺷور

ًﻼﻣﺎـﮐ مﺎﺧ تﺎﻋﻼﻃا ﻦﯾا ﻪﮐ ﺖﺳا و هﺪـﺷ يراﺪـﻬﮕﻧ ﻪـﻧﺎﻣﺮﺤﻣ

ﺌﯿﻫ ﯽﻤﻠﻋ ﺖ - رﺎـﺸﺘﻧا ﻖـﺣ ﺰـﯿﻧ ﮏـﻧﺎﺑ ﯽـﯾاﺮﺟا آ

ن ﺪـﻨﻫاﻮﺨﻧ ار

نﺎﻨﭼ .ﺖﺷاد ﻪﭼ

ﻞﯿﻠﺤﺗ هرود يﺎﻫ رد يا

ﻪﻨﯿﻣز ﺞﯾﺎـﺘﻧ ﺎﻬﻧژ ﻞﻣﺎﻌﺗ

ﺑ يرﺎﺸﺘﻧا ﻞﺑﺎﻗ ﻪ

رﺎﺑ آ درو

، ﺎﺑ ناﺮﮕﺸﻫوﮋﭘ ﻮﮕﺘﻔﮔ ﻪﻃﻮﺑﺮﻣ

ﺎﺗ هﺪﺷ

ﻪﻟﺎﻘﻣ و ﻪﯿﻬﺗ كﺮﺘﺸﻣ يا ﻧﻮﻤﻧ نﻮﻨﮐ ﺎﺗ .ﺪﺑﺎﯾ رﺎﺸﺘﻧا

ﻪ يﺎﻫ

،هﺪﺷدﺎﯾ

ياﺮﺑ ﺶﺷ هﺪـﺷ اﺪﻫا بﻮﺼﻣ هژوﺮﭘ ـﺳا

.ﺖ ﺪـﻧور ﻪـﺑ ﻪـﺟﻮﺗ ﺎـﺑ

ﯽﻣ رﺎﻈﺘﻧا دﻮﺟﻮﻣ

ﻪﻧﻻﺎـﺳ ﻪـﮐ دور ﺖـﺳد

ﻢـﮐ ﻦـﯾا زا هژوﺮـﭘ هد

ﻪﻧﻮﻤﻧ ﺎﻫ ﺑﻬ هﺮ يﺮﯿﮔ .ﺪﻨﯾﺎﻤﻧ

ﯽﻟﺎﺣ رد ﻪﻧﻮﻤﻧ ﻪﮐ يﺎﻫ

ﯽـﺳرﺮﺑ ياﺮـﺑ دﻮﺟﻮﻣ

ﯽـﭘا يﺎـﻫ ﯽـﮑﯿﺘﻧژ

ﻪﺑ ﯽﻓﺎﮐ ﺮﻈﻧ ﯽﻣ ،ﺪﺳر ﺖﯾدوﺪﺤﻣ زا ﯽﮑﯾ حﺮﻃ يﺎﻫ

، ﻢـﮐ ندﻮـﺑ

رﺎﻤﺷ ﻪﻧﻮﻤﻧ ياﺮﺑ ﺎﻫ ﺶﻫوﮋﭘ يﺎـﻫ يدﺮـﺒﻫار

ﯽـﻣ ﯽـﮑﯿﺘﻧژ .ﺪـﺷﺎﺑ

ﺶﯾاﺰﻓا ﻪﭼﺮﮔ رﺎﻤﺷ

ﻪﻧﻮﻤﻧ

فﺪـﻫ ﻪـﻠﻤﺟ زا ﺎﻫ يﺎـﻫ

نﺎـﯿﻣ تﺪـﻣ

ﯽﻣ حﺮﻃ ﺪﺷﺎﺑ

، ﺎﺗ ﻪـﺑ ﯽﺑﺎﯿﺘﺳد آ

ﯽـﻣ ن

ﯽـﻧاواﺮﻓ ﻪـﺴﯾﺎﻘﻣ ﺎـﺑ ناﻮـﺗ

لوﺪﺟ 1 - ﻪﻧﻮﻤﻧ ﯽﻧاواﺮﻓ ﻊﯾزﻮﺗ ﯽﮔﮋﯾو ﯽﺧﺮﺑ ﺐﺴﺣﺮﺑ ﯽﺳرﺮﺑ درﻮﻣ يﺎﻫ

ﺖﯿﻌﻤﺟ يﺎﻫ ) ﯽﺘﺧﺎﻨﺷ

302 (N=

ﯽﺼﯿﺨﺸﺗ هوﺮﮔ

ﻞﮐ داﺪﻌﺗ نز)

، (دﺮﻣ و ﯽﻨﺳ ﻦﯿﮕﻧﺎﯿﻣ

*SD (نز) و ﯽﻨﺳ ﻦﯿﮕﻧﺎﯿﻣ

SD (دﺮﻣ) ) ﯽﮑﺷﺰﭙﻧاور يرﺎﻤﯿﺑ ﯽﻠﯿﻣﺎﻓ ﻪﻘﺑﺎﺳ

نز

، دﺮﻣ (

لﺮﺘﻨﮐ 75

) 41 ، 24 ( 17 /8 35± / 35 51

/6 36± / 31 3

) 3 ، 0 (

ﺎﯿﻧﺮﻓوﺰﯿﮑﺳا 70

) 16 ، 54 ( 3/

8 9/± 37 5/

8 4/± 35 20

) 2

، 18 (

ﯽﺒﻄﻗود لﻼﺘﺧا

101 ) 45 ، 56 ( 4/

13 4/± 35 6/

12 7/± 30 31

) 14

، 17 (

ﯽﺳاﻮﺳو لﻼﺘﺧا -

ا ﺒﺟ ﺎ ير 27

) 20 ، 7 ( 5/

8 7/± 33 5/

8 9/± 26 22

) 20 ، 2 (

لﻼﺘﺧا ﯽﮔدﺮﺴﻓا ﯽﺳﺎﺳا 11

) 7 ، 4 ( 6/

9 9/± 36 1/

5 7/± 34 9

) 7 ، 2 (

رﺎﭼد نارﺎﻤﯿﺑ لوا ﻪﺟرد نﺎﮕﺘﺴﺑ ﺎﯿﻧﺮﻓوﺰﯿﮑﺳا و ﯽﺒﻄﻗ ود لﻼﺘﺧا

28 ) 12 ، 16 ( 25 /9 34± / 50 87

/ 12 35± / 37 28

ﻞﮐ داﺪﻌﺗ 302

) 124 ، 178 ( 85 / 10 31± / 35 22

/ 10 28± / 33 113

* standard deviation

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ﯽﻠﭘ ﯿﻓرﻮﻣ ﻢﺴ ﺎﻫ ﺖﯿﻌﻤﺟ ي رﺎﺠﻨﻬﺑ

و ﯽﻧاﺮﯾا

رد ﻪـﮐ ﻊـﻣاﻮﺟ ﺮﯾﺎﺳ

هﺎﮕﯾﺎﭘ يﺎﻫ دﻮﺟﻮﻣ سﺮﺘـﺳد رد

ﻪﯾﺎﻤﯿـﺳ ﻪـﺑ ﺖـﺳا دﻮـﺟﻮﻣ يﺎـﻫ

ﺖﯿﻌﻤﺟ ﯽﮑﯿﺘﻧژ .دﺮﺑ ﯽﭘ ﯽﻧاﺮﯾا

يراﺰﮕﺳﺎﭙﺳ

،ناﺮــﻬﺗ ﯽﮑــﺷﺰﭙﻧاور ﻮﺘﯿﺘــﺴﻧا زا ﯽــﺷزﻮﻣآ ﺰــﮐﺮﻣ

- ﯽﻧﺎــﻣرد

ﺰﭙﻧاور ناﺮﯾا ﯽﮑﺷ مﺮـﮐا لﻮﺳر نﺎﺘﺳرﺎﻤﯿﺑ ،

(ص) و ﺰـﯿﻧ نارﺎـﻤﯿﺑ

ﺮﻣ ﻦﯾا ا ﺰـﮐ اﻮﻧﺎـﺧ و هد ﯽـﺸﻫوﮋﭘ حﺮـﻃ ﻦـﯾا رد ﻪـﮐ نﺎـﻧآ يﺎـﻫ

ﻢــﻫ .دﻮــﺷ ﯽــﻣ ﯽﻧادرﺪــﻗ ،ﺪﻨﺘــﺷاد يرﺎــﮑﻤﻫ ﺰــﮐﺮﻣ زا ﻦﯿــﻨﭼ

ﯽﮑــﺷﺰﭘ مﻮــﻠﻋ هﺎﮕــﺸﻧاد ناور ﺖــﺷاﺪﻬﺑ تﺎــﻘﯿﻘﺤﺗ ــﻬﺗ

ناﺮ

ﻪﺑ يراﺰﮕﺳﺎﭙﺳ ،ﺶﻫوﮋﭘ ﻦﯾا ﻪﺟدﻮﺑ ﻦﯿﻣﺄﺗ و ﯽﻟﺎﻣ ﺖﯾﺎﻤﺣﺮﻃﺎﺧ

.ددﺮﮔ ﯽﻣ

ﺖﺳا ﻪﺘﺷاﺪﻧ دﻮﺟو ﻊﻓﺎﻨﻣ ضرﺎﻌﺗ ،ﻪﻟﺎﻘﻣ لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ رﺎﻬﻇا ﻪﺑ ﺎﻨﺑ ] . [

ﺎﻨﻣ ﻊﺑ

Abdolmaleky, H. M., Faraone, S. V., Glatt, S. J.,& Tsuang, M. T. (2004). Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophrenia Research, 67, 53-62.

Amano, K., Yamada, K., Iwayama, Y., Detera-Wadleigh, S. D., Hattori, E., Toyota, T., Tokunaga, K., Yoshikawa, T., &Yamakawa, K. (2008). Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder. Psychiatric Genetics, 18, 1-10.

Anitha, A., Nakamura, K., Yamada, K., Iwayama, Y., Toyota, T., Takei, N., Iwata, Y., & Mori, N. (2008).

Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. Biological Psychiatry, 63, 678-685.

Behan, A., Byrne, C., Dunn, M. J., Cagney, G., & Cotter, D. R. (2008). Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. Molecular Psychiatry, 14, 601-613.

Chen, Q., Wang, X., O'Neil, F. A., Walsh, D., Kendler, K.

S., & Chen, X. (2008). Is the histidine triad nucleotide- binding protein 1 (HINT1) gene a candidate for schizophrenia?

Schizophrenia Research, 106, 200-207.

Coriell institute for medical research (2009). Coriell institute for medical research. Available on:

http://ccr.coriell.org(88/12/23) De Luca, V., Likhodi, O., Van Tol, H. H., Kennedy, J. L.,

&Wong, A. H.(2006). Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects.

International Journal of Neuropsychopharmacology, 9, 21-25.

De Luca, V., Likhodi, O., Van Tol, H. H., Kennedy, J. L.,

& Wong, A. H. (2006). Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia. Acta Psychiatrica Scandinavica, 114, 211-215.

De Luca, V., Likhodi, O., Van Tol, H. H., Kennedy, J. L.,

& Wong, A. H. (2005). Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology, 183, 378-382.

Dracheva, S., Chin, B., & Haroutunian, V. (2008). Altered serotonin 2C receptor RNA splicing in suicide:

Association with editing. NeuroReport, 19, 379-382.

Dracheva, S., Patel, N., Woo, D. A., Marcus, S. M., Siever, L. J., & Haroutunian, V. (2007). Increased serotonin 2C receptor mRNA editing: A possible risk factor for suicide. Molocular Psychiatry, 13, 1001-1010.

Elashoff, M., Higgs, B. W., Yolken, R. H., Knable, M. B., Weis, S., Webster, M. J., Barci, B. M., &Torrey, E, F.

(2007). Meta-analysis of 12 genomic studies in bipolar disorder. Journal of Molocular Neurosciences, 31, 221-244.

Eastwood, S. L., & Harrison, P. J. (2007). Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.

Neuropsychopharmacology, 33, 933-945.

Feldcamp, L. A., Souza, R. P., Romano-Silva, M., Kennedy, J.

L., & Wong, A. H. (2008). Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophrenia. Schizophrenia Research, 103, 192-200.

First, M. B., Spitzer, R. L., Gibbon, M., &Williams, J. B.

(2006). Structured Clinical Interview for the DSM-IV Axis 1 Disorders (Persian translated version). Tehran:

Mehr-e-Kavian Publishers.

Galloux, J. C. (2003). An empirical survey on biobanking of human genetic material and data in six EU countries. European Journal of Humans Genetics, 11, 475-488.

Downloaded from ijpcp.iums.ac.ir at 12:01 CEST on Wednesday October 8th 2014

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Vol. 17 / No. 4 / Winter 2012

Ghadirivasfi, M., Nohesara, S., Ahmadkhaniha, H,R., Eskandari, M., Mostafavi, S., Thiagalingam, S., &

Mostafavi Abdolmaleky, H. (2011). Hypomethylation of the Serotonin Receptor Type-2A Gene (HTR2A) at T102C Polymorphic Site in DNA Derived From the Saliva of Patients With Schizophrenia and Bipolar.

American Journal of Medical Genetics part B, 156, 536-345.

Higgs, B. W., Elashoff, M., Richman, S., & Barci, B.

(2006). An online database for brain disease research.

BMC Genomics, 7-70.

Hobbs, J. A. (2006). Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex. Journal of Neurovirology, 12, 190-199.

Ide, M., Muratake, T., Yamada, K., Iwayama-Shigeno, Y., Iwamoto, K., Takao, H., Toyota, T., Kaneko, N. T., &

Yoshikawa, T. (2004). Genetic and expression analyses of FZD3 in schizophrenia. Biological Psychiatry, 56, 462-465.

Jansen, B. (2009). Bio-banking and genetic testing: A comparison between European countries and India.

Journal of International Bioethique, 20, 147-148.

Kato, T., Iwayama, Y., Kakiuchi, C., Iwamoto, K., Yamada, K., Minabe, Y., Nakamura, K., Mori, N., Fujii, K., Nanko, S., & Yoshikawa, T. (2005). Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Molocular Psychiatry, 10, 1045-1055.

Kyodo International Inc. (2012). Oragene RNA for Expression Analysis RNA Self-Collection Kit. Available on:

http://www.kyodo-inc.co.jp/english/bio/oragene-rna/

index.html

Mitkus, S., Lipska, B. K., Caruso, M., Hyde, T. M., Chen, J., Vakkalanka, R., Straub, R. E., Weinberger, D. R., &

Kleinman, J. E. (2006). RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity.

Human Molocular Genetics, 15, 2804-2812.

National Institute of Nuurological Disorders and Stroke (2011). NINDS Human Genetics Resource Center.

Available on: www.ninds.nih.gov/cell_tissue_dna.

Nohesara, S., Ghadirivasfi, M., Mostafav, S., Eskandari, M. R., Ahmadkhaniha, H. R., Thiagalingam, S., Mostafavi Abdolmaleky, H. (2011). DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva

in schizophrenia and bipolar disorder. Journal of Psychiatric Research, 45, 1432-1438.

Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C. M., Wait, R., Dunn, M. J., &

Cotter, D. R. (2007). Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Molocular Psychiatry, 13, 1102-1117.

Pillai, A. (2008). Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: A correlation with BDNF expression.

PLoS ONE, 3, e1784.

Pinsonneault, J. K., Papp, A. C., & Sadée, W. (2006).

Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: Dissection of epigenetic and genetic factors. Human Molocular Genetics, 15, 2636-2649.

Porton, B., &Wetsel, W. C. (2007). Reduction of synaps in III in the prefrontal cortex of individuals with schizophrenia. Schizophrenia Research, 94, 366-370.

Rogers, N. L., Cole, S. A., Lan, H. C., Crossa, A., Ellen, W., & Demerath, E. W. (2007). New saliva DNA collection method compared to buccal cell collection techniques for epidemiological studies issue. American Journal of Human Biology, 19, 319-326.

Ryan, M. M., Lockstone, H. E., Huffaker, S. J., Wayland, M. T., Webster, M. J., & Bahn, S. (2006). Gene expression analysis of bipolar disorder reveals down regulation of the ubiquitin cycle and alterations in synaptic genes. Molocular Psychiatry, 11, 965-978.

Sabunciyan, S., Kirches, E., Krause, G., Bogerts, B., Mawrin, C., Llenos, I. C., & Weis, S. (2007). Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorder. Journal of Neural Transmission, 114, 665-674.

Sartorius, L. J., Weinberger, D. R., Hyde, T. M., Harrison, P. J., Kleinman, J. E., & Lipska, B. K. (2008). Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. Neuropsychopharmacology, 33, 2626-2634

Downloaded from ijpcp.iums.ac.ir at 12:01 CEST on Wednesday October 8th 2014

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331

Severance, E. G., & Yolken, R. H. (2007). Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorder. Neuroscience, 148, 454-460.

Severance, E. G., & Yolken, R. H. (2008). Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia. Genes, Brain and Behavior, 7, 37-45.

Shao, L., & Vawter, M. P. (2008). Shared gene expression alterations in schizophrenia and bipolar disorder.

Biological Psychiatry, 64, 89-97.

Sharifi, V., Assadi, S. M., Mohammadi, M.R., Amini, H., Kaviani, H., Semnani, Y., Shabani, A., Shahrivar, Z., Davari-Ashtiani, R., Hakim Shooshtari, M., Seddigh, A., & Jalali, M. (2007). Short Communication Structured Clinical Interview for DSM-IV (SCID): Persian translation and cultural adaptation. Iran Journal of Psychiatry, 1, 46-48.

Stanley Medical Research Institute (2012). Stanley Medical Research Institute: Online Genomics Database

.

Available on: www.stanleygenomics.org

Sun, X., Wang, J. F., Tseng, M., & Young, L. T. (2006).

Down regulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. Journal of Psychiatry and Neuroscience, 31, 189-196.

Thiselton, D. L., Vladimirov, V. I., Kuo, P. H., McClay, J.,

Wormley, B., Fanous, A., O'Neill, F. A., Walsh, D., Van den Oord, E. J., Kendler, K. S., & Riley, B. P.

(2008). AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biological Psychiatry, 63, 449-457.

Wesley Research Institute (2007). Wesley Research Institute Tissue Bank. Available on: www.wesleyresearch.

org.au/tissue-bank.

Wilson, G. M., Flibotte, S., Chopra, V., Melnyk, B. L., Honer, W. G., & Holt, R. A. (2006). DNA copy- number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling. Human Molocular Genetics, 15, 743-749.

Xu, B., Wratten, N., Charych, E. I., Buyske, S., Firestein, B. L., & Brzustowicz, L. M. (2005). Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. PLoS Medicine, 2(10), e263.

Zhu, Y., Kalbfleisch, T., Brennan, M. D., & Li, Y. (2009).

A MicroRNA gene is hosted in an intron of a schizophrenia susceptibility gene. Schizophrenia Research, 109, 86-89.